Synthesis and evaluation of anti-tubercular activity of 6-(4-substitutedpiperazin-1-yl) phenanthridine analogues

European Journal of Medicinal Chemistry

Volumn 74, Issue , 2014, Pages 333-339

  Nagesh, Hunsur Nagendra ^a   Suresh, Narva ^a   Mahalakshmi Naidu, Kalaga ^a   Arun, Boyineni ^a   Padma Sridevi, Jonnalagadda ^a   Sriram, Dharmarajan ^a   Yogeeswari, Perumal ^a   Sekhar, Kondapalli Venkata Gowri Chandra ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Anti tubercular activity; Microwave synthesis; Phenanthridine; Piperazine; X ray crystallography

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXO 7 [4 [2 [4 (PHENANTHRIDIN 6 YL)PIPERAZIN 1 YL]ACETYL]PIPERAZIN 1 YL]QUINOLINE 3 CARBOXYLIC ACID; 2 [4 (PHENANTHRIDIN 6 YL)PIPERAZIN 1 YL]BENZONITRILE; 3 [4 (PHENANTHRIDIN 6 YL)PIPERAZIN 1 YL]PHENOL; 6 (4 BENZHYDRYLPIPERAZIN 1 YL)PHENANTHRIDINE; 6 (4 CINNAMYLPIPERAZIN 1 YL)PHENANTHRIDINE; 6 (4 ETHYLPIPERAZIN 1 YL)PHENANTHRIDINE; 6 (4 METHYLPIPERAZIN 1 YL)PHENANTHRIDINE; 6 (4 PHENETHYLPIPERAZIN 1 YL)PHENANTHRIDINE; 6 (PIPERAZIN 1 YL)PHENANTHRIDINE; 6 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]PHENANTHRIDINE; 6 [4 (3 METHOXYPHENYL)PIPERAZIN 1 YL]PHENANTHRIDINE; 6 [4 (3 METHYLPHENYL)PIPERAZIN 1 YL]PHENANTHRIDINE; 6 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]PHENANTHRIDINE; 6 [4 (4 NITROPHENYL)PIPERAZIN 1 YL]PHENANTHRIDINE; 6 [4 (4 VINYLBENZYL)PIPERAZIN 1 YL]PHENANTHRIDINE; 6 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PHENANTHRIDINE; 6 [4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL]PHENANTHRIDINE; ISONIAZID; PHENANTHRIDINE DERIVATIVE; PIPERAZINE DERIVATIVE; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; RESAZURIN ASSAY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTI-TUBERCULAR ACTIVITY; MICROWAVE SYNTHESIS; PHENANTHRIDINE; PIPERAZINE; X-RAY CRYSTALLOGRAPHY;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PHENANTHRIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84893343131     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.005     Document Type: Article

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