Pathogenesis of prediabetes: Role of the liver in isolated fasting hyperglycemia and combined fasting and postprandial hyperglycemia

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 3, 2013, Pages

  Basu, Rita ^a,d   Barosa, Cristina ^b   Jones, John ^b,c   Dube, Simmi ^a   Carter, Rickey ^a   Basu, Ananda ^a   Rizza, Robert A ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c Portuguese Diabetes Association   (Portugal)

^d Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; CLINICAL ARTICLE; DIABETOGENESIS; DIET RESTRICTION; FASTING HYPERGLYCEMIA; GLUCONEOGENESIS; GLUCOSE TOLERANCE; GLYCOGENOLYSIS; HUMAN; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; LIVER; POSTPRANDIAL HYPERGLYCEMIA; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADULT; AGED; BLOOD GLUCOSE; C-PEPTIDE; CARBON ISOTOPES; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; GLUCAGON; GLUCONEOGENESIS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; GLYCOGENOLYSIS; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; INSULIN; LIVER; MALE; MIDDLE AGED; PREDIABETIC STATE;

EID: 84874826222     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3056     Document Type: Article

References (25)

1. Dinneen SF, Maldonado D III, Leibson CL, et al. Effects of changing diagnostic criteria on the risk of developing diabetes. Diabetes Care. 1998;21:1408-1413. (Pubitemid 28405190)
2. Meigs JB, Muller DC, Nathan DM, Blake DR, Andres R. The nat- E416 Basu et al Pathogenesis of Prediabetes J Clin Endocrinol Metab, March 2013, 98(3):E409-E417 ural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore longitudinal study of aging. Diabetes. 2003;52:1475-1484. (Pubitemid 36666204)
3. Saad MF, Knowler WC, Pettitt DJ, Nelson FG, Mott DM, Bennett PH. The natural history of impaired glucose tolerance in the Pima Indians. N Engl J Med. 1988;319:1500-1506. (Pubitemid 19003408)
4. Hanefeld M, Koehler C, Fuecker K, Henkel E, Schaper F, Temelkova-Kurktschiev T. Insulin secretion and insulin sensitivity pattern is different in isolated impaired glucose tolerance and impaired fasting glucose. Diabetes Care. 2003;26:868-874.
5. Bock G, Dalla Man C, Campioni M, et al. Pathogenesis of prediabetes: mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance. Diabetes. 2006;55:3536-3549. (Pubitemid 44923615)
6. Meyer C, Pimenta W, Woerle HJ, et al. Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans. Diabetes Care. 2006;29:1909-1914. (Pubitemid 44156651)
7. Tripathy D, Carlsson M, Almgren P, et al. Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes. 2000;49:975-980. (Pubitemid 30349420)
8. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, American Diabetes Association GENNID Study Group. β-Cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes. 2002;51:2170-2178. (Pubitemid 34729022)
9. Ferrannini E, Gastaldelli A, Miyazaki Y, et al. Predominant role of reduced β-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance. Diabetologia. 2003;46:1211-1219. (Pubitemid 37214979)
10. Utzschneider KM, Prigeon RL, Carr DB, et al. Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses. Diabetes Care. 2006;29:356-362. (Pubitemid 44106518)
11. Perreault L, Bergman BC, Playdon MC, Dalla Man C, Cobelli C, Eckel RH. Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes? Am J Physiol Endocrinol Metab. 2008;295:E428-E435.
12. Weyer C, Bogardus C, Pratley RE. Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance. Diabetes. 1999;48:2197-2203. (Pubitemid 29521850)
13. Bock G, Chittilapilly E, Basu R, et al. Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis. Diabetes. 2007;56:1703-1711. (Pubitemid 46842609)
14. Basu R, Barosa C, Basu A, et al. Transaldolase exchange and its effects on measurements of gluconeogenesis in humans. Am J Physiol Endocrinol Metab. 2011;300:E296-E303.
15. Basu R, Schwenk F, Rizza RA. Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes. Am J Physiol Endocrinol Metab. 2004;287:E55- E62.
16. Basu R, Di Camillo B, Toffolo G, et al. Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab. 2003;284:E55-E69. (Pubitemid 36076223)
17. Basu A, Basu R, Shah P, et al. Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity. Diabetes. 2001;50:1351-1362. (Pubitemid 32500168)
18. Rizza RA, Mandarino LJ, Gerich JE. Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol. 1981;240:E630-E639.
19. Jones JG, Barosa C, Gomes F, et al. NMR derivatives for quantification of 2H and 13C-enrichment of human glucuronide from metabolic tracers. J Carbohydr Chem. 2006;25:203-217. (Pubitemid 43898367)
20. Jones JG, Fagulha A, Barosa C, et al. Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen. Diabetes. 2006;55:2294-2300. (Pubitemid 44743627)
21. Steele J, Wall JS, De Bodo RC, Altszuler N, Kiang SP, Bjerkins C. Measurement of size or turnover rate of body glucose pool by the isotopic dilution method. Am J Physiol. 1965;187:15-24.
22. Basu R, Chandramouli V, Dicke B, Landau B, Rizza R. Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis. Diabetes. 2005;54:1942-1948. (Pubitemid 40911255)
23. Bock G, Schumann WC, Basu R, et al. Evidence that processes other than gluconeogenesis may influence the ratio of deuterium on the fifth and third carbons of glucose: implications for the use of 2H2O to measure gluconeogenesis in humans. Diabetes. 2008;57:50-55.
24. Basu R, Chandramouli V, Schumann W, Basu A, Landau BR, Rizza RA. Additional evidence that transaldolase exchange, isotope discrimination during the triose-isomerase reaction, or both occur in humans: effects of type 2 diabetes. Diabetes. 2009;58:1539-1543.
25. Ramnanan CJ, Edgerton DS, Rivera N, et al. Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes. 2010;59:1302-1311.