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Volumn 25, Issue 3, 2015, Pages 525-541

Is tranexamic acid clinically effective and safe to prevent blood loss in total knee arthroplasty? A meta-analysis of 34 randomized controlled trials

Author keywords

Blood loss; Meta analysis; TKA; Tranexamic acid; Transfusion

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

EID: 84925506880     PISSN: 16338065     EISSN: 14321068     Source Type: Journal    
DOI: 10.1007/s00590-014-1568-z     Document Type: Article
Times cited : (78)

References (46)
  • 3
    • 84865605964 scopus 로고    scopus 로고
    • Perioperative bleeding and early mortality in hip and knee surgery
    • COI: 1:STN:280:DC%2BC38fptlWqsg%3D%3D, PID: 22906428
    • Vielpeau C (2012) Perioperative bleeding and early mortality in hip and knee surgery. Orthop Traumatol Surg Res 98(5):475–476
    • (2012) Orthop Traumatol Surg Res , vol.98 , Issue.5 , pp. 475-476
    • Vielpeau, C.1
  • 5
    • 0029942003 scopus 로고    scopus 로고
    • The risk of transfusion transmitted viral infections: the retrovirus epidemiology donor study
    • COI: 1:STN:280:DyaK283ktVGhug%3D%3D, PID: 8637512
    • Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ (1996) The risk of transfusion transmitted viral infections: the retrovirus epidemiology donor study. N Engl J Med 334(26):1685–1690
    • (1996) N Engl J Med , vol.334 , Issue.26 , pp. 1685-1690
    • Schreiber, G.B.1    Busch, M.P.2    Kleinman, S.H.3    Korelitz, J.J.4
  • 6
    • 84893956215 scopus 로고    scopus 로고
    • Low vacuum re-infusion drains after total knee arthroplasty: is there a real benefit?
    • PID: 24120601
    • Muñoz M, Cobos A, Campos A (2014) Low vacuum re-infusion drains after total knee arthroplasty: is there a real benefit? Blood Transfus 12(Suppl 1):s173–s175
    • (2014) Blood Transfus , vol.12 , pp. 173-175
    • Muñoz, M.1    Cobos, A.2    Campos, A.3
  • 7
    • 84893916056 scopus 로고    scopus 로고
    • Autologous re-transfusion drain compared with no drain in total knee arthroplasty: a randomised controlled trial
    • PID: 24120589
    • Horstmann W, Kuipers B, Ohanis D, Slappendel R, Kollen B, Verheyen C (2014) Autologous re-transfusion drain compared with no drain in total knee arthroplasty: a randomised controlled trial. Blood Transfus 12(Suppl 1):s176–s181
    • (2014) Blood Transfus , vol.12 , pp. 176-181
    • Horstmann, W.1    Kuipers, B.2    Ohanis, D.3    Slappendel, R.4    Kollen, B.5    Verheyen, C.6
  • 8
    • 84882411216 scopus 로고    scopus 로고
    • Blood management and transfusion strategies in 600 patients undergoing total joint arthroplasty: an analysis of pre-operative autologous blood donation
    • PID: 23736922
    • Perazzo P, Viganò M, De Girolamo L, Verde F, Vinci A, Banfi G, Romagnoli S (2013) Blood management and transfusion strategies in 600 patients undergoing total joint arthroplasty: an analysis of pre-operative autologous blood donation. Blood Transfus 11(3):370–376
    • (2013) Blood Transfus , vol.11 , Issue.3 , pp. 370-376
    • Perazzo, P.1    Viganò, M.2    De Girolamo, L.3    Verde, F.4    Vinci, A.5    Banfi, G.6    Romagnoli, S.7
  • 9
    • 0026525226 scopus 로고
    • Natural and synthetic antifibrino-lytics in cardiac surgery
    • COI: 1:STN:280:DyaK383isVegtw%3D%3D, PID: 1373346
    • Hardy JF, Desroches J (1992) Natural and synthetic antifibrino-lytics in cardiac surgery. Can J Anaesth 39(4):353–365
    • (1992) Can J Anaesth , vol.39 , Issue.4 , pp. 353-365
    • Hardy, J.F.1    Desroches, J.2
  • 10
    • 61449083511 scopus 로고    scopus 로고
    • Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis
    • PID: 19247741
    • Abrishami A, Chung F, Wong J (2009) Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis. Can J Anaesth 56(3):202–212
    • (2009) Can J Anaesth , vol.56 , Issue.3 , pp. 202-212
    • Abrishami, A.1    Chung, F.2    Wong, J.3
  • 11
    • 84861503406 scopus 로고    scopus 로고
    • Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis
    • PID: 22611164
    • Ker K, Edwards P, Perel P, Shakur H, Roberts I (2012) Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 344:e3054
    • (2012) BMJ , vol.344 , pp. 3054
    • Ker, K.1    Edwards, P.2    Perel, P.3    Shakur, H.4    Roberts, I.5
  • 12
    • 84865457785 scopus 로고    scopus 로고
    • The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis
    • PID: 22065294
    • Zhang H, Chen J, Chen F, Que W (2012) The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc 20(9):1742–1752
    • (2012) Knee Surg Sports Traumatol Arthrosc , vol.20 , Issue.9 , pp. 1742-1752
    • Zhang, H.1    Chen, J.2    Chen, F.3    Que, W.4
  • 14
    • 84865111800 scopus 로고    scopus 로고
    • Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial
    • COI: 1:CAS:528:DC%2BC38Xhs1yrtb7P, PID: 22817651
    • Chareancholvanich K, Siriwattanasakul P, Narkbunnam R, Pornrattanamaneewong C (2012) Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial. BMC Musculoskelet Disord 13:124
    • (2012) BMC Musculoskelet Disord , vol.13 , pp. 124
    • Chareancholvanich, K.1    Siriwattanasakul, P.2    Narkbunnam, R.3    Pornrattanamaneewong, C.4
  • 15
    • 84884161814 scopus 로고    scopus 로고
    • A prospective double-blind placebo controlled trial of topical tranexamic acid in total knee arthroplasty
    • PID: 23906869
    • Georgiadis AG, Muh SJ, Silverton CD, Weir RM, Laker MW (2013) A prospective double-blind placebo controlled trial of topical tranexamic acid in total knee arthroplasty. J Arthroplasty 28(8 Suppl):78–82
    • (2013) J Arthroplasty , vol.28 , pp. 78-82
    • Georgiadis, A.G.1    Muh, S.J.2    Silverton, C.D.3    Weir, R.M.4    Laker, M.W.5
  • 16
    • 84904556598 scopus 로고    scopus 로고
    • Clinical value of tranexamic acid in unilateral and simultaneous bilateral TKAs under a contemporary blood-saving protocol: a randomized controlled trial
    • PID: 23592025
    • Kim TK, Chang CB, Kang YG, Seo ES, Lee JH, Yun JH, Lee SH (2014) Clinical value of tranexamic acid in unilateral and simultaneous bilateral TKAs under a contemporary blood-saving protocol: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc 22(8):1870–1878
    • (2014) Knee Surg Sports Traumatol Arthrosc , vol.22 , Issue.8 , pp. 1870-1878
    • Kim, T.K.1    Chang, C.B.2    Kang, Y.G.3    Seo, E.S.4    Lee, J.H.5    Yun, J.H.6    Lee, S.H.7
  • 17
    • 84885953472 scopus 로고    scopus 로고
    • Less blood loss under concomitant administration of tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty: a prospective randomized controlled trial
    • PID: 23052111
    • Lee SH, Cho KY, Khurana S, Kim KI (2013) Less blood loss under concomitant administration of tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty: a prospective randomized controlled trial. Knee Surg Sports Traumatol Arthrosc 21(11):2611–2617
    • (2013) Knee Surg Sports Traumatol Arthrosc , vol.21 , Issue.11 , pp. 2611-2617
    • Lee, S.H.1    Cho, K.Y.2    Khurana, S.3    Kim, K.I.4
  • 19
    • 84913529667 scopus 로고    scopus 로고
    • The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty
    • Pachauri A, Acharya KK, Tiwari AK (2013) The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty. Am J Ther 21(5):366–370
    • (2013) Am J Ther , vol.21 , Issue.5 , pp. 366-370
    • Pachauri, A.1    Acharya, K.K.2    Tiwari, A.K.3
  • 20
    • 84870300273 scopus 로고    scopus 로고
    • Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty
    • PID: 22419263
    • Roy SP, Tanki UF, Dutta A, Jain SK, Nagi ON (2012) Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 20(12):2494–2501
    • (2012) Knee Surg Sports Traumatol Arthrosc , vol.20 , Issue.12 , pp. 2494-2501
    • Roy, S.P.1    Tanki, U.F.2    Dutta, A.3    Jain, S.K.4    Nagi, O.N.5
  • 21
    • 84880646604 scopus 로고    scopus 로고
    • The comparative efficacies of intra-articular and IV tranexamic acid for reducing blood loss during total knee arthroplasty
    • PID: 22729012
    • Seo JG, Moon YW, Park SH, Kim SM, Ko KR (2013) The comparative efficacies of intra-articular and IV tranexamic acid for reducing blood loss during total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 21(8):1869–1874
    • (2013) Knee Surg Sports Traumatol Arthrosc , vol.21 , Issue.8 , pp. 1869-1874
    • Seo, J.G.1    Moon, Y.W.2    Park, S.H.3    Kim, S.M.4    Ko, K.R.5
  • 22
    • 84882687017 scopus 로고    scopus 로고
    • Timing and volume of topical tranexamic acid administration for postoperative blood loss in total knee arthroplasty
    • Abrishami A (2010) Timing and volume of topical tranexamic acid administration for postoperative blood loss in total knee arthroplasty. Can J Anesth 51:S142–S143
    • (2010) Can J Anesth , vol.51 , pp. 142-143
    • Abrishami, A.1
  • 23
    • 39749175072 scopus 로고    scopus 로고
    • Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied
    • PID: 18067499
    • Alvarez JC, Santiveri FX, Ramos I, Vela E, Puig L, Escolano F (2008) Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion 48(3):519–525
    • (2008) Transfusion , vol.48 , Issue.3 , pp. 519-525
    • Alvarez, J.C.1    Santiveri, F.X.2    Ramos, I.3    Vela, E.4    Puig, L.5    Escolano, F.6
  • 24
    • 0029891721 scopus 로고    scopus 로고
    • Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients
    • COI: 1:STN:280:DyaK283hvFKjsg%3D%3D, PID: 8636182
    • Benoni G, Fredin H (1996) Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br 78(3):434–440
    • (1996) J Bone Joint Surg Br , vol.78 , Issue.3 , pp. 434-440
    • Benoni, G.1    Fredin, H.2
  • 25
    • 33645892258 scopus 로고    scopus 로고
    • Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial
    • COI: 1:CAS:528:DC%2BD28Xjtlamsr0%3D, PID: 16531440
    • Camarasa MA, Ollé G, Serra-Prat M, Martín A, Sánchez M, Ricós P, Pérez A, Opisso L (2006) Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 96(5):576–582
    • (2006) Br J Anaesth , vol.96 , Issue.5 , pp. 576-582
    • Camarasa, M.A.1    Ollé, G.2    Serra-Prat, M.3    Martín, A.4    Sánchez, M.5    Ricós, P.6    Pérez, A.7    Opisso, L.8
  • 26
    • 80054765052 scopus 로고    scopus 로고
    • Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial
    • PID: 21512813
    • Charoencholvanich K, Siriwattanasakul P (2011) Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clin Orthop Relat Res 469(10):2874–2880
    • (2011) Clin Orthop Relat Res , vol.469 , Issue.10 , pp. 2874-2880
    • Charoencholvanich, K.1    Siriwattanasakul, P.2
  • 27
    • 0034749975 scopus 로고    scopus 로고
    • The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement
    • COI: 1:CAS:528:DC%2BD3MXotFSqtrs%3D, PID: 11704449
    • Ellis MH, Fredman B, Zohar E, Ifrach N, Jedeikin R (2001) The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement. J Clin Anesth 13(7):509–513
    • (2001) J Clin Anesth , vol.13 , Issue.7 , pp. 509-513
    • Ellis, M.H.1    Fredman, B.2    Zohar, E.3    Ifrach, N.4    Jedeikin, R.5
  • 28
    • 0035124072 scopus 로고    scopus 로고
    • Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin
    • COI: 1:CAS:528:DC%2BD3MXitF2gtr4%3D, PID: 11226117
    • Engel JM, Hohaus T, Ruwoldt R, Menges T, Jürgensen I, Hempelmann G (2001) Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin. Anesth Analg 92(3):775–780
    • (2001) Anesth Analg , vol.92 , Issue.3 , pp. 775-780
    • Engel, J.M.1    Hohaus, T.2    Ruwoldt, R.3    Menges, T.4    Jürgensen, I.5    Hempelmann, G.6
  • 29
    • 84855453125 scopus 로고    scopus 로고
    • Effect of tranexamic acid on blood loss and transfusion requirement in total knee replacement in the Indian population: a case series
    • COI: 1:CAS:528:DC%2BC38XltFWkuw%3D%3D, PID: 22223903
    • Gautam PL, Katyal S, Yamin M, Singh A (2011) Effect of tranexamic acid on blood loss and transfusion requirement in total knee replacement in the Indian population: a case series. Indian J Anaesth 55(6):590–593
    • (2011) Indian J Anaesth , vol.55 , Issue.6 , pp. 590-593
    • Gautam, P.L.1    Katyal, S.2    Yamin, M.3    Singh, A.4
  • 30
    • 0038732462 scopus 로고    scopus 로고
    • Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement
    • COI: 1:CAS:528:DC%2BD3sXktVCgsLY%3D, PID: 12697586
    • Good L, Peterson E, Lisander B (2003) Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 90(5):596–599
    • (2003) Br J Anaesth , vol.90 , Issue.5 , pp. 596-599
    • Good, L.1    Peterson, E.2    Lisander, B.3
  • 32
    • 0029033838 scopus 로고
    • Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty
    • COI: 1:STN:280:DyaK2M3ptVejtg%3D%3D, PID: 7772427
    • Hiippala S, Strid L, Wennerstrand M, Arvela V, Mäntylä S, Ylinen J, Niemelä H (1995) Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 74(5):534–537
    • (1995) Br J Anaesth , vol.74 , Issue.5 , pp. 534-537
    • Hiippala, S.1    Strid, L.2    Wennerstrand, M.3    Arvela, V.4    Mäntylä, S.5    Ylinen, J.6    Niemelä, H.7
  • 34
    • 0032837284 scopus 로고    scopus 로고
    • Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty
    • COI: 1:CAS:528:DyaK1MXmvFansrc%3D, PID: 10673876
    • Jansen AJ, Andreica S, Claeys M, D’Haese J, Camu F, Jochmans K (1999) Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty. Br J Anaesth 83(4):596–601
    • (1999) Br J Anaesth , vol.83 , Issue.4 , pp. 596-601
    • Jansen, A.J.1    Andreica, S.2    Claeys, M.3    D’Haese, J.4    Camu, F.5    Jochmans, K.6
  • 35
    • 83455260053 scopus 로고    scopus 로고
    • Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial
    • COI: 1:STN:280:DC%2BC3cnotVKguw%3D%3D, PID: 20640094
    • Kakar PN, Gupta N, Govil P, Shah V (2009) Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial. Indian J Anaesth 53(6):667–671
    • (2009) Indian J Anaesth , vol.53 , Issue.6 , pp. 667-671
    • Kakar, P.N.1    Gupta, N.2    Govil, P.3    Shah, V.4
  • 36
    • 84866387754 scopus 로고    scopus 로고
    • Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients
    • PID: 22419350
    • Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR (2012) Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res 470(9):2605–2612
    • (2012) Clin Orthop Relat Res , vol.470 , Issue.9 , pp. 2605-2612
    • Maniar, R.N.1    Kumar, G.2    Singhi, T.3    Nayak, R.M.4    Maniar, P.R.5
  • 37
    • 84861710918 scopus 로고    scopus 로고
    • Reducing blood loss in primary knee arthroplasty: a prospective randomised controlled trial of tranexamic acid and fibrin spray
    • PID: 21733697
    • McConnell JS, Shewale S, Munro NA, Shah K, Deakin AH, Kinninmonth AW (2012) Reducing blood loss in primary knee arthroplasty: a prospective randomised controlled trial of tranexamic acid and fibrin spray. Knee 19(4):295–298
    • (2012) Knee , vol.19 , Issue.4 , pp. 295-298
    • McConnell, J.S.1    Shewale, S.2    Munro, N.A.3    Shah, K.4    Deakin, A.H.5    Kinninmonth, A.W.6
  • 38
    • 34147187909 scopus 로고    scopus 로고
    • Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial
    • COI: 1:STN:280:DC%2BD2s7ls1Wmtg%3D%3D, PID: 17356139
    • Molloy DO, Archbold HA, Ogonda L, McConway J, Wilson RK, Beverland DE (2007) Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br 89(3):306–309
    • (2007) J Bone Joint Surg Br , vol.89 , Issue.3 , pp. 306-309
    • Molloy, D.O.1    Archbold, H.A.2    Ogonda, L.3    McConway, J.4    Wilson, R.K.5    Beverland, D.E.6
  • 39
    • 83555172507 scopus 로고    scopus 로고
    • Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty
    • PID: 21435821
    • Onodera T, Majima T, Sawaguchi N, Kasahara Y, Ishigaki T, Minami A (2012) Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty. J Arthroplasty 27(1):105–108
    • (2012) J Arthroplasty , vol.27 , Issue.1 , pp. 105-108
    • Onodera, T.1    Majima, T.2    Sawaguchi, N.3    Kasahara, Y.4    Ishigaki, T.5    Minami, A.6
  • 40
    • 33644863872 scopus 로고    scopus 로고
    • Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients
    • PID: 16487712
    • Orpen NM, Little C, Walker G, Crawfurd EJ (2006) Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. Knee 13(2):106–110
    • (2006) Knee , vol.13 , Issue.2 , pp. 106-110
    • Orpen, N.M.1    Little, C.2    Walker, G.3    Crawfurd, E.J.4
  • 41
    • 0034915776 scopus 로고    scopus 로고
    • Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee
    • COI: 1:STN:280:DC%2BD3MvivFSitQ%3D%3D, PID: 11476309
    • Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S (2001) Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br 83(5):702–705
    • (2001) J Bone Joint Surg Br , vol.83 , Issue.5 , pp. 702-705
    • Tanaka, N.1    Sakahashi, H.2    Sato, E.3    Hirose, K.4    Ishima, T.5    Ishii, S.6
  • 42
    • 18744405998 scopus 로고    scopus 로고
    • Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study
    • COI: 1:CAS:528:DC%2BD38XpsFKnsr4%3D, PID: 12421192
    • Veien M, Sørensen JV, Madsen F, Juelsgaard P (2002) Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study. Acta Anaesthesiol Scand 46(10):1206–1211
    • (2002) Acta Anaesthesiol Scand , vol.46 , Issue.10 , pp. 1206-1211
    • Veien, M.1    Sørensen, J.V.2    Madsen, F.3    Juelsgaard, P.4
  • 44
    • 68149160346 scopus 로고    scopus 로고
    • Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty
    • COI: 1:CAS:528:DC%2BD1cXislyjtbw%3D, PID: 18277670
    • Zhang F, Gao Z, Yu J (2007) Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21(12):1302–1304
    • (2007) Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi , vol.21 , Issue.12 , pp. 1302-1304
    • Zhang, F.1    Gao, Z.2    Yu, J.3
  • 45
    • 9244255860 scopus 로고    scopus 로고
    • The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement
    • PID: 15562053
    • Zohar E, Ellis M, Ifrach N, Stern A, Sapir O, Fredman B (2004) The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg 99(6):1679–1683
    • (2004) Anesth Analg , vol.99 , Issue.6 , pp. 1679-1683
    • Zohar, E.1    Ellis, M.2    Ifrach, N.3    Stern, A.4    Sapir, O.5    Fredman, B.6
  • 46
    • 84883875521 scopus 로고    scopus 로고
    • A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty
    • COI: 1:CAS:528:DC%2BC3sXntVaktbY%3D, PID: 23643299
    • Tan J, Chen H, Liu Q, Chen C, Huang W (2013) A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res 184(2):880–887
    • (2013) J Surg Res , vol.184 , Issue.2 , pp. 880-887
    • Tan, J.1    Chen, H.2    Liu, Q.3    Chen, C.4    Huang, W.5


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