Vasorelaxant activities of danhong injection and their differential effects on the rat abdominal aorta and mesenteric artery

Journal of Cardiovascular Pharmacology

Volumn 65, Issue 1, 2015, Pages 62-71

  Su, Xianming ^a   Zhi, Xiaowen ^a,b   Cui, Ting ^a,c   Zheng, Qiaowei ^a   Wang, Shixiang ^d   Cao, Yongxiao ^a   Cui, Changcong ^a   Feng, Weiyi ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Department of Ophthalmology   (China)

^c China Resources Sanjiu Medical and Pharmaceutical Co Ltd   (China)

^d NORTHWEST UNIVERSITY   (China)

Author keywords

Ca^{2+< sup> channel; Danhong injection; vasorelaxant effect}

Indexed keywords

CAFFEINE; CHINESE DRUG; DANHONG; INOSITOL TRISPHOSPHATE; NORADRENALIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; VASODILATOR AGENT; CALCIUM; CALCIUM CHANNEL; HERBACEOUS AGENT;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY PERFUSION; ARTICLE; CALCIUM TRANSPORT; CHINESE MEDICINE; CONTROLLED STUDY; FEMALE; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR RESISTANCE; VASCULARIZATION; VASOCONSTRICTION; VASODILATATION; ANIMAL; DRUG EFFECTS; METABOLISM; RABBIT; SPRAGUE DAWLEY RAT;

ANIMALS; AORTA, ABDOMINAL; CALCIUM; CALCIUM CHANNELS; DRUGS, CHINESE HERBAL; FEMALE; MALE; MESENTERIC ARTERIES; NOREPINEPHRINE; POTASSIUM CHLORIDE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; VASODILATION; VASODILATOR AGENTS;

EID: 84925506076     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000164     Document Type: Article

References (40)

1. Cheng TO. Cardiovascular effects of Danshen. Int J Cardiol. 2007;121: 9-22.
2. Han JY, Fan JY, Horie Y, et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol Ther. 2008;117:280-295.
3. Lam FF, Yeung JH, Chan KM, et al. Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vascul Pharmacol. 2007;46:271-277.
4. Zhou X, Tang L, Xu Y, et al. Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: a phytochemical and pharmacological review. J Ethnopharmacol. 2014;151:27-43.
5. Ma XJ, Yin SJ, Jin JC, et al. Synergistic protection of Danhong injection and ischemic postconditioning on myocardial reperfusion injury in minipigs. Chin J Integr Med. 2010;16:531-536.
6. He Y, Wan H, Du Y, et al. Protective effect of Danhong injection on cerebral ischemia-reperfusion injury in rats. J Ethnopharmacol. 2012; 144:387-394.
7. Liu H, Wang S, Sun A, et al. Danhong inhibits oxidized low-density lipoprotein-induced immune maturation of dentritic cells via a peroxisome proliferator activated receptor g-mediated pathway. J Pharmacol Sci. 2012;119:1-9.
8. Wan LM, Tan L, Wang ZR, et al. Preventive and therapeutic effects of Danhong injection on lipopolysaccharide induced acute lung injury in mice. J Ethnopharmacol. 2013;149:352-359.
9. Gao LN, Cui YL, Wang QS, et al. Amelioration of Danhong injection on the lipopolysaccharide-stimulated systemic acute inflammatory reaction via multi-target strategy. J Ethnopharmacol. 2013;149:772-782.
10. Sun M, Zhang JJ, Shan JZ, et al. Clinical observation of Danhong Injection (herbal TCM product from Radix Salviae miltiorrhizae and Flos Carthami tinctorii) in the treatment of traumatic intracranial hematoma. Phytomedicine. 2009;16:683-689.
11. Yao JY, Zhi M, Cao WT, et al. Successful treatment with danhong injection for hepatic veno-occlusive disease. Hepatogastroenterology. 2011;58:992-995.
12. Wang ZL, Liu M, Zhang YQ. The prevention of denhong injection on contrast-induced renal impairment after percutaneous coronary intervention [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011;31:1611-1614.
13. Guan Y, Yin Y, Zhu YR, et al. Dissection of mechanisms of a chinese medicinal formula: danhong injection therapy for myocardial ischemia/reperfusion injury in vivo and in vitro. Evid Based Complement Alternat Med. 2013;2013:972370.
14. Liu HT, Wang YF, Olaleye O, et al. Characterization of in vivo antioxidant constituents and dual-standard quality assessment of Danhong injection. Biomed Chromatogr. 2013;27:655-663.
15. Liu X, Wu Z, Yang K, et al. Quantitative analysis combined with chromatographic fingerprint for comprehensive evaluation of Danhong injection using HPLC-DAD. J Pharm Biomed Anal. 2013;76:70-74.
16. Wang D, Fan G, Wang Y, et al. Vascular reactivity screen of Chinese medicine danhong injection identifies Danshensu as a NO-independent but PGI2-mediated relaxation factor. J Cardiovasc Pharmacol. 2013;62: 457-465.
17. Zhi XW, Su XM, Feng WY, et al. Effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats [in Chinese]. Zhongguo Zhong Yao Za Zhi. 2012;37:2607-2611.
18. Waldbillig DK, Pang SC. Differential proliferation of rat aortic and mesenteric smooth muscle cells in culture. Histol Histopath. 1992;7:199-207.
19. Kamata K, Makino A. A comparative study on the rat aorta and mesenteric arterial bed of the possible role of nitric oxide in the desensitization of the vasoconstrictor response to an a1-adrenoceptor agonist. Br J Pharmacol. 1997;120:1221-1228.
20. Catterall WA. Voltage-gated calcium channels. Cold Spring Harb Perspect Biol. 2011;3:a003947.
21. Ko EA, Han J, Jung ID, et al. Physiological roles of K+ channels in vascular smooth muscle cells. J Smooth Muscle Res. 2008;44:65-81.
22. Gitterman DP, Evans RJ. Properties of P2X and P2Y receptors are dependent on artery diameter in the rat mesenteric bed. Br J Pharmacol. 2000;131:1561-1568.
23. Adegunloye BJ, Sofola OA. Differential responses of rat aorta and mesenteric artery to norepinephrine and serotonin in vitro. Pharmacology. 1997;55:25-31.
24. Adegunloye B, Su X, Camper EV, et al. Sensitivity of rabbit aorta and mesenteric artery to norepinephrine: role of tyrosine kinases. Eur J Pharmacol. 2003;476:201-209.
25. Montenegro MF, Pessa LR, Gomes VA, et al. Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bed. Basic Clin Pharmacol Toxicol. 2009;104:400-407.
26. Berman RS, Griffith TM. Differential actions of charybdotoxin on central and daughter branch arteries of the rabbit isolated ear. Br J Pharmacol. 1997;120:639-646.
27. Cao YX, Zhang W, He JY, He LC, et al. Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptormediated Ca2+ influx and release. Vascul Pharmacol. 2006;45:171-176.
28. Faber JE, Szymeczek CL, Cotecchia S, et al. Alpha1-adrenoceptor dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2007;292: H2316-H2323.
29. Zhang H, Faber JE. Trophic effect of norepinephrine on arterial intimamedia and adventitia is augmented by injury and mediated by different a1-adrenoceptor subtypes. Circ Res. 2001;89:815-822.
30. Adameova A, Abdellatif Y, Dhalla NS. Role of the excessive amounts of circulating catecholamines and glucocorticoids in stress-induced heart disease. Can J Physiol Pharmacol. 2009;87:493-514.
31. Higashi Y, Sasaki S, Nakagawa K, et al. Excess norepinephrine impairs both endothelium-dependent and-independent vasodilation in patients with pheochromocytoma. Hypertension. 2002;39:513-518.
32. Karaki H, Ozaki H, Hori M, et al. Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev. 1997;49:157-230.
33. Katzung BG. Basic and clinical pharmacology. Biaggioni I, Robertson D, eds. Adrenoceptor Agonists and Sympathomimetic Drugs. 12th ed. New York: McGraw-Hill Inc., 2011, pp 130-133.
34. Lam FF, Yeung JH, Chan KM, et al. Dihydrotanshinone, alipophilic component of Salvia miltiorrhiiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J Ethnopharmacol. 2008; 119:318-321.
35. Zhang N, Zou H, Jin L, et al. Biphasic effects of sodium danshensu on vessel function in isolated rat aorta. Acta Pharmacol Sin. 2010;31:421-428.
36. Porta M, Zima AV, Nani A, et al. Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks. Biophys J. 2011;100:931-938.
37. Leijten PA, Van Breemen C. The effects of caffeine on the noradrenalinesensitive calcium store in rabbit aorta. J Physiol. 1984;357:327-339.
38. Jackson WF. Potassium channels and proliferation of vascular smooth muscle cells. Circ Res. 2005;97:1211-1212.
39. Wu SN. Large-conductance Ca2+-activated K+ channels: physiological role and pharmacology. Curr Med Chem. 2003;10:649-661.
40. Jackson WF. Potassium channels in the peripheral microcirculation. Microcirculation. 2005;12:113-127.