MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats

Annals of the Rheumatic Diseases

Volumn 75, Issue 3, 2016, Pages 601-608

  Nakamachi, Yuji ^a   Ohnuma, Kenichiro ^a,b   Uto, Kenichi ^a,b   Noguchi, Yoriko ^a,b   Saegusa, Jun ^a,b   Kawano, Seiji ^b  

^a KOBE UNIVERSITY HOSPITAL   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; FREUND ADJUVANT; MESSENGER RNA; MICRORNA 124; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; MICRORNA; MIRN124 MICRORNA, HUMAN; MIRN124 MICRORNA, RAT; NFATC1 PROTEIN, RAT; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKLE; ARTICLE; BONE DESTRUCTION; CARTILAGE DEGENERATION; CELL COUNT; CELL DIFFERENTIATION; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DRUG TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE; LEWIS RAT; LUCIFERASE ASSAY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIOCYTE; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SYNOVIUM;

ANIMALS; ANTIGENS, CD29; ARTHRITIS, EXPERIMENTAL; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; OSTEOCLASTS; RANK LIGAND; RATS; RATS, INBRED LEW; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; SYNOVIAL MEMBRANE; TRANSCRIPTION FACTORS;

EID: 84958989804     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206417     Document Type: Article

References (41)

1. Chu CY, Rana TM. Small RNAs: regulators and guardians of the genome. J Cell Physiol 2007;213:412-19.
2. Lee Y, Kim M, Han J, et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J 2004;23:4051-60.
3. Cai X, Hagedorn CH, Cullen BR. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 2004;10:1957-66.
4. Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003;425:415-9.
5. Hammond SM. Dicing and slicing: the core machinery of the RNA interference pathway. FEBS Lett 2005;579:5822-9.
6. Hutvagner G. Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation. FEBS Lett 2005;579:5850-7.
7. Doench JG, Sharp PA. Specificity of microRNA target selection in translational repression. Genes Dev 2004;18:504-11.
8. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20.
9. Das S, Bryan K, Buckley PG, et al. Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs. Oncogene 2013;32:2927-36.
10. Wienholds E, Kloosterman WP, Miska E, et al. MicroRNA expression in zebrafish embryonic development. Science 2005;309:310-11.
11. Kloosterman WP, Wienholds E, de Bruijn E, et al. In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat Methods 2006;3:27-9.
12. Ason B, Darnell DK, Wittbrodt B, et al. Differences in vertebrate miRNA expression. Proc Natl Acad Sci USA 2006;103:14385-9.
13. Aboobaker A, Tomancak P, Patel N, et al. Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci USA 2005;102:18017-22.
14. Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Development Cell 2006;11:4441-50.
15. Conaco C, Otto S, Han JJ, et al. Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci USA 2006;103:2422-7.
16. Sun Y1, Li Q, Gui H, et al. MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines. Cell Res 2013;23:1270-83.
17. Wicks I, Cooley H, Szer J, et al. Autologous hemopoietic stem cell transplantation: a possible cure for rheumatoid arthritis? Arthritis Rheum 1997;40:1005-11.
18. Panayi GS, Lanchbury JS, Kingsley GH. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 1992;35:729-35.
19. Zvaifler NJ, Firestein GS. Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 1994;37:783-9.
20. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61.
21. Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 2007;7:292-304.
22. Nakashima T, Hayashi M, Fukunaga T, et al. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med 2011;17:1231-4.
23. Takayanagi H, Kim S, Koga T, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling for terminal differentiation of osteoclasts. Dev Cell 2002;3:889-901.
24. Nakamachi Y, Kawano S, Takenokuchi M, et al. MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 2009;60:1294-304.
25. Allen RC, Gross KR, Laxer RM, et al. Intraarticular triamcinolone hexacetonide in the management of chronic arthritis in children. Arthritis Rheum 1986;29:997-1001.
26. Nakashima T, Takayanagi H. New regulation mechanisms of osteoclast differentiation. Ann N Y Acad Sci 2011;1240:E13-8.
27. Nakashima T, Kobayashi Y, Yamasaki S, et al. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappa B ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun 2000;275:768-75.
28. Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Ann Rev Immunol 2002;20:795-823.
29. Lee Y, Kim HJ, Park CK, et al. MicroRNA-124 regulates osteoclast differentiation. Bone 2013;56:383-9.
30. Nesbitt S, Nesbit A, Helfrich M, et al. Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrins. J Biol Chem 1993;268:16737-45.
31. Hunt S, Jones AV, Hinsley EE, et al. MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1. FEBS Lett 2011;585:187-92.
32. Rao H, Lu G, Kajiya H, et al. Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res 2006;21:1657-65.
33. Gendron S, Boisvert M, Chetoui N, et al. Alpha1beta1 integrin and interleukin-7 receptor up-regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function. Immunology 2008;125:359-69.
34. Okamoto H, Matsumi Y, Hoshikawa Y, et al. Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. PLoS ONE 2012;7:e43800.
35. Ikuta K, Waguri-Nagaya Y, Kikuchi K, et al. The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes. Arthritis Res Ther 2012;14:R87.
36. Sylvester J, Ahmad R, Zafarullah M. Role of Sp1 transcription factor in Interleukin-1-induced ADAMTS-4 (aggrecanase-1) gene expression in human articular chondrocytes. Rheumatol Int 2013;33:517-22.
37. Dong S, Zhang Z, Takahara H. Estrogen-enhanced peptidylarginine deiminase type IV gene (PADI4) expression in MCF-7 cells is mediated by estrogen receptor-alpha-promoted transfactors activator protein-1, nuclear factor-Y, and Sp1. Mol Endocrinol 2007;21:1617-29.
38. Kochi Y, Thabet MM, Suzuki A, et al. PADI4 polymorphism predisposes male smokers to rheumatoid arthritis. Ann Rheum Dis 2011;70:512-5.
39. Wang H, Iakova P, Wilde M, et al. C/EBP-alpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Mol Cell 2001;8:817-28.
40. Koukos G, Polytarchou C, Kaplan JL, et al. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology 2013;145:842-52.
41. Joosten LA, Helsen MM, Loo FA et al. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra. Arthritis Rheum 1996;39:797-809.