메뉴 건너뛰기




Volumn 65, Issue 1, 2015, Pages 13-21

Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-density lipoproteins and protective effects of grape seed procyanidin B2

Author keywords

apoptosis; glycated low density lipoproteins; grape seed procyanidin B2; human umbilical vein endothelial cells; prohibitin

Indexed keywords

CASPASE 3; CYTOCHROME C; GRAPE SEED PROCYANIDIN B2; LOW DENSITY LIPOPROTEIN; PROCYANIDIN; PROHIBITIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; BIFLAVONOID; CATECHIN; GRAPE SEED EXTRACT; PROANTHOCYANIDIN; PROCYANIDIN B2; REPRESSOR PROTEIN;

EID: 84925500489     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000157     Document Type: Article
Times cited : (22)

References (48)
  • 1
    • 35848959253 scopus 로고    scopus 로고
    • Impact of the metabolic syndrome on macrovascular and microvascular outcomes in type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study 78
    • Cull CA, Jensen CC, Retnakaran R, et al. Impact of the metabolic syndrome on macrovascular and microvascular outcomes in type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study 78. Circulation. 2007;116:2119-2126.
    • (2007) Circulation , vol.116 , pp. 2119-2126
    • Cull, C.A.1    Jensen, C.C.2    Retnakaran, R.3
  • 2
    • 75149182840 scopus 로고    scopus 로고
    • Depression and advanced complications of diabetes: A prospective cohort study
    • Lin EH, Rutter CM, Katon W, et al. Depression and advanced complications of diabetes: a prospective cohort study. Diabetes Care. 2010;33: 264-269.
    • (2010) Diabetes Care , vol.33 , pp. 264-269
    • Lin, E.H.1    Rutter, C.M.2    Katon, W.3
  • 3
    • 0030091280 scopus 로고    scopus 로고
    • Pathobiochemistry of combined diabetes and atherosclerosis studied on a novel animal model the hyperlipemic-hyperglycemic hamster
    • Simionescu M, Popov D, Sima A, et al. Pathobiochemistry of combined diabetes and atherosclerosis studied on a novel animal model. The hyperlipemic-hyperglycemic hamster. Am J Pathol. 1996;148: 997-1014.
    • (1996) Am J Pathol , vol.148 , pp. 997-1014
    • Simionescu, M.1    Popov, D.2    Sima, A.3
  • 4
    • 33646343715 scopus 로고    scopus 로고
    • Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: Pathogenic and therapeutic implications
    • Cohen MP, Ziyadeh FN, Chen S. Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: pathogenic and therapeutic implications. J Lab Clin Med. 2006;147:211-219.
    • (2006) J Lab Clin Med , vol.147 , pp. 211-219
    • Cohen, M.P.1    Ziyadeh, F.N.2    Chen, S.3
  • 5
    • 62649164710 scopus 로고    scopus 로고
    • Glycoxidized LDL increases lectinlike oxidized low density lipoprotein receptor-1 in diabetes mellitus
    • Shiu SW, Tan KC, Wong Y, et al. Glycoxidized LDL increases lectinlike oxidized low density lipoprotein receptor-1 in diabetes mellitus. Atherosclerosis. 2009;203:522-527.
    • (2009) Atherosclerosis , vol.203 , pp. 522-527
    • Shiu, S.W.1    Tan, K.C.2    Wong, Y.3
  • 6
    • 0021361691 scopus 로고
    • Interaction of human endothelial cells with elevated glucose concentrations and native and glycosylated low density lipoproteins
    • Lorenzi M, Cagliero E, Markey B, et al. Interaction of human endothelial cells with elevated glucose concentrations and native and glycosylated low density lipoproteins. Diabetologia. 1984;26: 218-222.
    • (1984) Diabetologia , vol.26 , pp. 218-222
    • Lorenzi, M.1    Cagliero, E.2    Markey, B.3
  • 7
    • 0345034617 scopus 로고    scopus 로고
    • Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress-activated L-arginine uptake in endothelial cells
    • Posch K, Simecek S, Wascher TC, et al. Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress-activated L-arginine uptake in endothelial cells. Diabetes. 1999;48:1331-1337.
    • (1999) Diabetes , vol.48 , pp. 1331-1337
    • Posch, K.1    Simecek, S.2    Wascher, T.C.3
  • 8
    • 77956028829 scopus 로고    scopus 로고
    • Involvement of RAGE NADPH oxidase and Ras/Raf-1 pathway in glycated LDL-induced expression of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells
    • Sangle GV, Zhao R, Mizuno TM, et al. Involvement of RAGE, NADPH oxidase, and Ras/Raf-1 pathway in glycated LDL-induced expression of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells. Endocrinology. 2010;151: 4455-4466.
    • (2010) Endocrinology , vol.151 , pp. 4455-4466
    • Sangle, G.V.1    Zhao, R.2    Mizuno, T.M.3
  • 9
    • 34248164474 scopus 로고    scopus 로고
    • Involvement of heat shock factor-1 in glycated LDLinduced upregulation of plasminogen activator inhibitor-1 in vascular endothelial cells
    • Zhao R, Shen GX. Involvement of heat shock factor-1 in glycated LDLinduced upregulation of plasminogen activator inhibitor-1 in vascular endothelial cells. Diabetes. 2007;56:1436-1444.
    • (2007) Diabetes , vol.56 , pp. 1436-1444
    • Zhao, R.1    Shen, G.X.2
  • 10
    • 26244452534 scopus 로고    scopus 로고
    • The inflammatory properties of electronegative low-density lipoprotein from type 1 diabetic patients are related to increased platelet-activating factor acetylhydrolase activity
    • Sanchez-Quesada JL, Benitez S, Perez A, et al. The inflammatory properties of electronegative low-density lipoprotein from type 1 diabetic patients are related to increased platelet-activating factor acetylhydrolase activity. Diabetologia. 2005;48:2162-2169.
    • (2005) Diabetologia , vol.48 , pp. 2162-2169
    • Sanchez-Quesada, J.L.1    Benitez, S.2    Perez, A.3
  • 11
    • 17444368974 scopus 로고    scopus 로고
    • Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells
    • Brown BE, Dean RT, Davies MJ. Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells. Diabetologia. 2005;48:361-369.
    • (2005) Diabetologia , vol.48 , pp. 361-369
    • Brown, B.E.1    Dean, R.T.2    Davies, M.J.3
  • 12
    • 84860573915 scopus 로고    scopus 로고
    • Antioxidant and cytoprotective effects of oligomeric and polymeric procyanidin fractions from defatted grape in PC12 cells
    • Kim Y, Choi Y, Ham H, et al. Antioxidant and cytoprotective effects of oligomeric and polymeric procyanidin fractions from defatted grape in PC12 cells. J Med Food. 2012;15:490-494.
    • (2012) J Med Food , vol.15 , pp. 490-494
    • Kim, Y.1    Choi, Y.2    Ham, H.3
  • 13
    • 34547756444 scopus 로고    scopus 로고
    • Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-330-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells
    • Agarwal C, Veluri R, Kaur M, et al. Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,30-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis. 2007;28:1478-1484.
    • (2007) Carcinogenesis , vol.28 , pp. 1478-1484
    • Agarwal, C.1    Veluri, R.2    Kaur, M.3
  • 14
    • 37849009071 scopus 로고    scopus 로고
    • Comparative examination of antiproliferative activities of (-)-epigallocatechin gallate and (-)-epigallocatechin against HCT116 colorectal carcinoma cells
    • Inaba H, Nagaoka Y, Kushima Y, et al. Comparative examination of antiproliferative activities of (-)-epigallocatechin gallate and (-)-epigallocatechin against HCT116 colorectal carcinoma cells. Biol Pharm Bull. 2008;31:79-84.
    • (2008) Biol Pharm Bull , vol.31 , pp. 79-84
    • Inaba, H.1    Nagaoka, Y.2    Kushima, Y.3
  • 15
    • 0037051517 scopus 로고    scopus 로고
    • Antitumor activity of compounds isolated from leaves of Eriobotrya japonica
    • Ito H, Kobayashi E, Li SH, et al. Antitumor activity of compounds isolated from leaves of Eriobotrya japonica. J Agric Food Chem. 2002;50:2400-2403.
    • (2002) J Agric Food Chem , vol.50 , pp. 2400-2403
    • Ito, H.1    Kobayashi, E.2    Li, S.H.3
  • 16
    • 85027918754 scopus 로고    scopus 로고
    • Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol
    • Li BY, Li XL, Cai Q, et al. Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol. Apoptosis. 2011;16:732-745.
    • (2011) Apoptosis , vol.16 , pp. 732-745
    • Li, B.Y.1    Li, X.L.2    Cai, Q.3
  • 17
    • 79959239046 scopus 로고    scopus 로고
    • Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3b phosphorylation
    • Li BY, Li XL, Gao HQ, et al. Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3b phosphorylation. Cell Biol Int. 2011;35: 663-669.
    • (2011) Cell Biol Int , vol.35 , pp. 663-669
    • Li, B.Y.1    Li, X.L.2    Gao, H.Q.3
  • 18
    • 84871381369 scopus 로고    scopus 로고
    • Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage
    • Yu F, Li BY, Li XL, et al. Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. PLoS One. 2012;7:e52541.
    • (2012) PLoS One , vol.7 , pp. e52541
    • Yu, F.1    Li, B.Y.2    Li, X.L.3
  • 19
    • 0027383492 scopus 로고
    • Cell cycle activity and expression of prohibitin mRNA
    • Roskams AJ, Friedman V, Wood CM, et al. Cell cycle activity and expression of prohibitin mRNA. J Cell Physiol. 1993;157: 289-295.
    • (1993) J Cell Physiol , vol.157 , pp. 289-295
    • Roskams, A.J.1    Friedman, V.2    Wood, C.M.3
  • 20
    • 33845878868 scopus 로고    scopus 로고
    • Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin
    • Chowdhury I, Xu W, Stiles JK, et al. Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin. Endocrinology. 2007;148:206-217.
    • (2007) Endocrinology , vol.148 , pp. 206-217
    • Chowdhury, I.1    Xu, W.2    Stiles, J.K.3
  • 21
    • 0035325241 scopus 로고    scopus 로고
    • Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence
    • Coates PJ, Nenutil R, McGregor A, et al. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. Exp Cell Res. 2001;265:262-273.
    • (2001) Exp Cell Res , vol.265 , pp. 262-273
    • Coates, P.J.1    Nenutil, R.2    McGregor, A.3
  • 22
    • 37449032942 scopus 로고    scopus 로고
    • Taspine isolated from Radix et Rhizoma Leonticis inhibits growth of human umbilical vein endothelial cell (HUVEC) by inducing its apoptosis
    • Zhang Y, He L, Zhou Y. Taspine isolated from Radix et Rhizoma Leonticis inhibits growth of human umbilical vein endothelial cell (HUVEC) by inducing its apoptosis. Phytomedicine. 2008;15:112-119.
    • (2008) Phytomedicine , vol.15 , pp. 112-119
    • Zhang, Y.1    He, L.2    Zhou, Y.3
  • 23
    • 34447630674 scopus 로고    scopus 로고
    • Hyperglycaemia and cardiovascular disease
    • Bartnik M, Norhammar A, Ryden L. Hyperglycaemia and cardiovascular disease. J Intern Med. 2007;262:145-156.
    • (2007) J Intern Med , vol.262 , pp. 145-156
    • Bartnik, M.1    Norhammar, A.2    Ryden, L.3
  • 24
    • 0027537768 scopus 로고
    • Glycation and oxidation: A role in the pathogenesis of atherosclerosis
    • Lyons TJ. Glycation and oxidation: a role in the pathogenesis of atherosclerosis. Am J Cardiol. 1993;71:26B-31B.
    • (1993) Am J Cardiol , vol.71 , pp. 26B-31B
    • Lyons, T.J.1
  • 25
    • 0029847340 scopus 로고    scopus 로고
    • The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes
    • King GL. The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes. Ann Med. 1996;28:427-432.
    • (1996) Ann Med , vol.28 , pp. 427-432
    • King, G.L.1
  • 26
    • 0031157387 scopus 로고    scopus 로고
    • Glycated low-density lipoprotein and atherogenesis: The missing link between diabetes mellitus and hypercholesterolaemia?
    • Graier WF, Kostner GM. Glycated low-density lipoprotein and atherogenesis: the missing link between diabetes mellitus and hypercholesterolaemia? Eur J Clin Invest. 1997;27:457-459.
    • (1997) Eur J Clin Invest , vol.27 , pp. 457-459
    • Graier, W.F.1    Kostner, G.M.2
  • 27
    • 33747196977 scopus 로고    scopus 로고
    • The prohibitins: Emerging roles in diverse functions
    • Mishra S, Murphy LC, Murphy LJ. The prohibitins: emerging roles in diverse functions. J Cell Mol Med. 2006;10:353-363.
    • (2006) J Cell Mol Med , vol.10 , pp. 353-363
    • Mishra, S.1    Murphy, L.C.2    Murphy, L.J.3
  • 29
    • 78149411945 scopus 로고    scopus 로고
    • Increased expression of prohibitin and its relationship with poor prognosis in esophageal squamous cell carcinoma
    • Ren HZ, Wang JS, Wang P, et al. Increased expression of prohibitin and its relationship with poor prognosis in esophageal squamous cell carcinoma. Pathol Oncol Res. 2010;16:515-522.
    • (2010) Pathol Oncol Res , vol.16 , pp. 515-522
    • Ren, H.Z.1    Wang, J.S.2    Wang, P.3
  • 30
    • 0027242336 scopus 로고
    • The human prohibitin (PHB) gene family and its somatic mutations in human tumors
    • Sato T, Sakamoto T, Takita K, et al. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. Genomics. 1993;17: 762-764.
    • (1993) Genomics , vol.17 , pp. 762-764
    • Sato, T.1    Sakamoto, T.2    Takita, K.3
  • 31
    • 34247097595 scopus 로고    scopus 로고
    • Prohibitin in the pathogenesis of transitional cell bladder cancer
    • Wu TF, Wu H, Wang YW, et al. Prohibitin in the pathogenesis of transitional cell bladder cancer. Anticancer Res. 2007;27:895-900.
    • (2007) Anticancer Res , vol.27 , pp. 895-900
    • Wu, T.F.1    Wu, H.2    Wang, Y.W.3
  • 32
    • 40749104734 scopus 로고    scopus 로고
    • Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis
    • Gregory-Bass RC, Olatinwo M, Xu W, et al. Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis. Int J Cancer. 2008;122:1923-1930.
    • (2008) Int J Cancer , vol.122 , pp. 1923-1930
    • Gregory-Bass, R.C.1    Olatinwo, M.2    Xu, W.3
  • 33
    • 80755125257 scopus 로고    scopus 로고
    • The effect of supplementation of grape seed proanthocyanidin extract on vascular dysfunction in experimental diabetes
    • Okudan N, Bariskaner H, Gokbel H, et al. The effect of supplementation of grape seed proanthocyanidin extract on vascular dysfunction in experimental diabetes. J Med Food. 2011;14:1298-1302.
    • (2011) J Med Food , vol.14 , pp. 1298-1302
    • Okudan, N.1    Bariskaner, H.2    Gokbel, H.3
  • 34
    • 33845968031 scopus 로고    scopus 로고
    • Prohibitin protects against oxidative stress in intestinal epithelial cells
    • Theiss AL, Idell RD, Srinivasan S, et al. Prohibitin protects against oxidative stress in intestinal epithelial cells. FASEB J. 2007;21: 197-206.
    • (2007) FASEB J , vol.21 , pp. 197-206
    • Theiss, A.L.1    Idell, R.D.2    Srinivasan, S.3
  • 35
    • 84905712553 scopus 로고    scopus 로고
    • Association of prohibitin-1 and 2 with oxidative stress in rats with renal interstitial fibrosis
    • Zhou TB, Qin YH, Lei FY, et al. Association of prohibitin-1 and 2 with oxidative stress in rats with renal interstitial fibrosis. Mol Biol Rep. 2014; 41:3033-3043.
    • (2014) Mol Biol Rep , vol.41 , pp. 3033-3043
    • Zhou, T.B.1    Qin, Y.H.2    Lei, F.Y.3
  • 36
    • 22144447861 scopus 로고    scopus 로고
    • Antioxidants as novel therapy in a murine model of colitis
    • Oz HS, Chen TS, McClain CJ, et al. Antioxidants as novel therapy in a murine model of colitis. J Nutr Biochem. 2005;16:297-304.
    • (2005) J Nutr Biochem , vol.16 , pp. 297-304
    • Oz, H.S.1    Chen, T.S.2    McClain, C.J.3
  • 37
    • 80053389292 scopus 로고    scopus 로고
    • Mitochondrial-nuclear communication by prohibitin shuttling under oxidative stress
    • Sripathi SR, He W, Atkinson CL, et al. Mitochondrial-nuclear communication by prohibitin shuttling under oxidative stress. Biochemistry. 2011;50:8342-8351.
    • (2011) Biochemistry , vol.50 , pp. 8342-8351
    • Sripathi, S.R.1    He, W.2    Atkinson, C.L.3
  • 38
    • 33748565348 scopus 로고    scopus 로고
    • Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens
    • Houde V, Grenier D, Chandad F. Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens. J Periodontol. 2006;77:1371-1379.
    • (2006) J Periodontol , vol.77 , pp. 1371-1379
    • Houde, V.1    Grenier, D.2    Chandad, F.3
  • 39
    • 84871685931 scopus 로고    scopus 로고
    • Impact of cyanidin-3-glucoside on glycated LDL-induced NADPH oxidase activation, mitochondrial dysfunction and cell viability in cultured vascular endothelial cells
    • Xie X, Zhao R, Shen GX. Impact of cyanidin-3-glucoside on glycated LDL-induced NADPH oxidase activation, mitochondrial dysfunction and cell viability in cultured vascular endothelial cells. Int J Mol Sci. 2012; 13:15867-15880.
    • (2012) Int J Mol Sci , vol.13 , pp. 15867-15880
    • Xie, X.1    Zhao, R.2    Shen, G.X.3
  • 40
    • 53849113943 scopus 로고    scopus 로고
    • Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose
    • Yang Z, Mo X, Gong Q, et al. Critical effect of VEGF in the process of endothelial cell apoptosis induced by high glucose. Apoptosis. 2008;13: 1331-1343.
    • (2008) Apoptosis , vol.13 , pp. 1331-1343
    • Yang, Z.1    Mo, X.2    Gong, Q.3
  • 41
    • 33745699393 scopus 로고    scopus 로고
    • OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
    • Frezza C, Cipolat S, Martins de Brito O, et al. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell. 2006; 126:177-189.
    • (2006) Cell , vol.126 , pp. 177-189
    • Frezza, C.1    Cipolat, S.2    Martins De Brito, O.3
  • 42
    • 39449112660 scopus 로고    scopus 로고
    • Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
    • Merkwirth C, Dargazanli S, Tatsuta T, et al. Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev. 2008;22:476-488.
    • (2008) Genes Dev , vol.22 , pp. 476-488
    • Merkwirth, C.1    Dargazanli, S.2    Tatsuta, T.3
  • 43
    • 6344235539 scopus 로고    scopus 로고
    • Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax
    • Zhang Z, Lapolla SM, Annis MG, et al. Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax. J Biol Chem. 2004;279:43920-43928.
    • (2004) J Biol Chem , vol.279 , pp. 43920-43928
    • Zhang, Z.1    Lapolla, S.M.2    Annis, M.G.3
  • 44
    • 33744953583 scopus 로고    scopus 로고
    • Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2
    • Tan C, Dlugosz PJ, Peng J, et al. Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2. J Biol Chem. 2006;281:14764-14775.
    • (2006) J Biol Chem , vol.281 , pp. 14764-14775
    • Tan, C.1    Dlugosz, P.J.2    Peng, J.3
  • 45
    • 38349014270 scopus 로고    scopus 로고
    • Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
    • Schleicher M, Shepherd BR, Suarez Y, et al. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. J Cell Biol. 2008;180:101-112.
    • (2008) J Cell Biol , vol.180 , pp. 101-112
    • Schleicher, M.1    Shepherd, B.R.2    Suarez, Y.3
  • 46
    • 0842263745 scopus 로고    scopus 로고
    • Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
    • Miyauchi H, Minamino T, Tateno K, et al. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 2004;23:212-220.
    • (2004) EMBO J , vol.23 , pp. 212-220
    • Miyauchi, H.1    Minamino, T.2    Tateno, K.3
  • 47
    • 84872737284 scopus 로고    scopus 로고
    • Inhibitory roles of prohibitin and chemerin in FSH-induced rat granulosa cell steroidogenesis
    • Wang Q, Leader A, Tsang BK. Inhibitory roles of prohibitin and chemerin in FSH-induced rat granulosa cell steroidogenesis. Endocrinology. 2013;154:956-967.
    • (2013) Endocrinology , vol.154 , pp. 956-967
    • Wang, Q.1    Leader, A.2    Tsang, B.K.3
  • 48
    • 84875837088 scopus 로고    scopus 로고
    • Follicular stage-dependent regulation of apoptosis and steroidogenesis by prohibitin in rat granulosa cells
    • Wang Q, Leader A, Tsang BK. Follicular stage-dependent regulation of apoptosis and steroidogenesis by prohibitin in rat granulosa cells. J Ovarian Res. 2013;6:23.
    • (2013) J Ovarian Res , vol.6 , pp. 23
    • Wang, Q.1    Leader, A.2    Tsang, B.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.