The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes

Annals of Medicine

Volumn 28, Issue 5, 1996, Pages 427-432

  King, George L ^a,b,c  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Growth factors; Insulin resistance; Protein kinase C; Vascular cells

Indexed keywords

CARDIOVASCULAR DISEASE; DIABETIC ANGIOPATHY; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; PRIORITY JOURNAL; SHORT SURVEY; VASCULARIZATION;

EID: 0029847340     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853899608999103     Document Type: Short Survey

References (36)

1. Krolewski AS, Warram JH, Rand LI, Kahn CR. Epidemiologic approach to etiology of type I diabetes mellitus and its complications. N Engl J Med 1987; 317: 1390-8.
2. Ruderman NB, Haudenschild C. Diabetes as an atherogenic factor. Prog Cardiovasc Dis 1984; 26: 373-412.
3. Ledet T. Histological and histochemical changes in the coronary arteries of old diabetic patients. Diabetologia 1961; 4: 268-72.
4. Krolewski AS, Kosinski EJ, Warrem JH, et al. Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol 1987; 58: 750-5.
5. Factor SM, Minase T, Sonnenblick EH. Clinical and morphological features of human hypertensive-diabetic cardiomyopathy. Am Heart J 1980; 99: 446-58.
6. King GL, Banskota NK. Mechanisms of diabetic microvascular complications. In: Kahn CR, Weir GC, eds. Joslin's Diabetes Mellitus, 13th edn. Philadelphia: Lea & Febiger, 1994: 633.
7. Colwell JA, Lopes-Virella M, Halushka PV. Pathogenesis of atherosclerosis in diabetes mellitus. Diabetes Care 1981; 4: 121-33.
8. Morgensen CE, Osterby R, Gundersen HJG. Early functional and morphologic vascular renal consequences of the diabetic state. Diabetologia 1979; 17: 71-6.
9. Cogan DG, Toussaint D, Kuwabara T. Retinal vascular patterns IV. Diabetic retinopathy. Arch Ophthalmol 1962; 69: 492-502a.
10. Ross R. Cell biology of atherosclerosis. Annu Rev Physiol 1995; 57: 791-804.
11. Seaquist ER, Goetz FC, Rich S, Barbosa J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989; 320: 1161-5.
12. Reaven GM, Laws A. Insulin resistance, compensatory hyperinsulinemia and coronary heart disease. Diabetologia 1994; 37: 948-52.
13. Ferrannini E, Natali A, Cerri M, Santoro D, Palombo C. Hypertension: a metabolic disorder? Diabetes Metab 1989; 15: 284-91.
14. Banskota NK, Taub R, Zellner K, Olsen P, King GL. Characterization of the induction of proto-oncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-I. Diabetes 1989; 38: 123-9.
15. Banskota NK, Taub R, Zellner K, King GL. Insulin, insulin-like growth factor I and platelet-derived growth factor interact synergistically in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells. Mol Endocrinol 1989; 3: 1183-90.
16. King GL, Davidheiser S, Banskota N, Oliver FJ, Inoguchi T. Insulin receptors and actions on vascular cells. In: Smith U, Bruun NE, Hedner T, Hökfelt B, eds. Hypertension as an Insulin-resistant Disorder. Genetic Factors and Cellular Mechanisms. Amsterdam: Elsevier Science Publishers, 1991: 183-97.
17. Hachiya HL, Halban PA, King GL. Intracellular pathways of insulin transport across vascular endothelial cells. Am J Physiol 1988; 255: C459-64.
18. Baron AD. Hemodynamic action of insulin. Am J Physiol 1994; 267: E187-202.
19. Grant M, King GL. IGF-1 and blood vessels. Implications for microvascular and macrovascular disease. Diabetes Rev 1995; 3: 113-28.
20. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-86.
21. 2. J Clin Invest 1995; 96: 733-40.
22. Kaiser N, Sasson S, Feener EP, Moller DE, King GL. Differential regulation of glucose transport and transporters by glucose in vascular endothelial and smooth muscle cells. Diabetes 1992; 42: 80-9.
23. Greene D, Lattimer SA, Sima AAF. Sorbitol, phosphoinositides and sodium potassium ATPase in the pathogenesis of diabetic complications. N Engl J Med 1987; 316: 599-60.
24. Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 1994; 43: 1122-9.
25. Inoguchi T, Xia P, Kunisaki M, Higashi S, Feener EP, King GL. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol 1994; 267: E369-79.
26. King GL, Shiba T, Oliver J, Inoguchi T, Bursell S-E. Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Annu Rev Med 1994; 45: 179-88.
27. Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform βII and diaclycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet transplantation. Proc. Natl Acad Sci USA 1992; 89: 11059-63.
28. Aiello LP, Robinson GS, Lin Y-W, Nishio Y, King GL. Identification of multiple glucose-related genes in bovine retinal pericytes by mRNA differential display. Proc Natl Acad Sci USA 1994; 91: 6231-5.
29. Lorenzi M. Glucose toxicity in the vascular complications of diabetes: The cellular perspective. Diabetes Metab Rev 1992; 8: 85-103.
30. Nordt TK, Klassen KJ, Schneider DJ, Sobel BE. Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis. Arterioscler Thromb 1993; 13: 1822-8.
31. Lababidi ZA, Goldstein DE. High prevalence of echocardiographic abnormalities in diabetic youths. Diabetes Care 1983; 6: 18-22.
32. Kessler II. Mortality experience of diabetic patients. Am J Med; 51: 715-24.
33. Reagan TJ, Lyons MM, Ahmed SS, et al. Evidence for cardiomyopathy in familial diabetes mellitus. J Clin Invest; 60: 885-99.
34. Yoshihiko N, Charles WE, Buczek-Thomas J, et al. Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. J Clin Invest 1995; 96: 1759-67.
35. Kunisaki M, Bursell S-E, Clermont AC, et al. Vitamin E treatment prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol 1995; 269: E239-46.
36. Kunisaki M, Bursell S-E, Umeda F, Nawata H, King GL. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes 1994; 43: 1372-7.