The Neurometabolic Fingerprint of Excessive Alcohol Drinking

Neuropsychopharmacology

Volumn 40, Issue , 2015, Pages 1259-1268

  Meinhardt, Marcus W ^a   Sévin, Daniel C ^b,c   Klee, Manuela L ^a   Dieter, Sandra ^a   Sauer, Uwe ^b   Sommer, Wolfgang H ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ETH ZURICH   (Switzerland)

^c Life Science Zurich   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; METENKEPHALIN; DOPAMINE; CENTRAL DEPRESSANT AGENT;

ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; ENERGY METABOLISM; MALE; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; NEUROMETABOLIC FINGERPRINT; NONHUMAN; NUCLEUS ACCUMBENS; NUCLEUS ACCUMBENS SHELL; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ALCOHOL ABSTINENCE; CORPUS STRIATUM; TISSUE LEVEL; ANIMAL; DECISION MAKING; DISEASE MODEL; DRINKING BEHAVIOR; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; WISTAR RAT; WITHDRAWAL SYNDROME;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBRAL CORTEX; CHOICE BEHAVIOR; DISEASE MODELS, ANIMAL; DOPAMINE; ENKEPHALIN, METHIONINE; ETHANOL; MALE; MASS SPECTROMETRY; NUCLEUS ACCUMBENS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84925490412     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2014.312     Document Type: Article

References (62)

1. Alexander-Kaufman K, Harper C (2009). Transketolase: observations in alcohol-related brain damage research. Int J Biochem Cell Biol 41: 717-720.
2. Arlinde C, Sommer W, Björk K, Reimers M, Hyytiä P, Kiianmaa K et al (2004). A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism. Pharmacogenomics J 4: 208-218.
3. Ayanwuyi LO, Carvajal F, Lerma-Cabrera JM, Domi E, Björk K, Ubaldi M et al (2013). Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcoholpreferring rats. Front Psychiatry 4: 23.
4. Bechara A, Damasio AR, Damasio H, Anderson SW (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7-15.
5. Björk K, Hansson AC, Sommer WH (2010). Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. Int Rev Neurobiol 91: 129-171.
6. Björk K, Saarikoski ST, Arlinde C, Kovanen L, Osei-Hyiaman D, Ubaldi M et al (2006). Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity. FASEB J 20: 1826-1835.
7. Björk K, Tronci V, Thorsell A, Tanda G, Hirth N, Heilig M et al (2013). b-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol. Psychopharmacology (Berl) 230: 439-449.
8. Bogdanov M, Matson WR, Wang L, Matson T, Saunders-Pullman R, Bressman SS et al (2008). Metabolomic profiling to develop blood biomarkers for Parkinson's disease. Brain 131: 389-396.
9. Chen X-L, Lu G, Gong Y-X, Zhao L-C, Chen J, Chi Z-Q et al (2007). Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment. Cell Res 17: 689-700.
10. Deng Y, Bu Q, Hu Z, Deng P, Yan G, Duan J et al (2012). 1) H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention. J Neurosci Res 90: 2154-2162.
11. Dettmer K, Aronov PA, Hammock BD (2007). Mass spectrometry-based metabolomics. Mass Spectrom Rev 26: 51-78.
12. Di Chiara G (1995). The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Depend 38: 95-137.
13. Di Chiara G, Imperato A (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85: 5274-5278.
14. Everitt BJ, Robbins TW (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8: 1481-1489.
15. Fuhrer T, Heer D, Begemann B, Zamboni N (2011). High-through-put, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry. Anal Chem 83: 7074-7080.
16. Gelernter J, Kranzler HR, Sherva R, Almasy L, Koesterer R, Smith AH et al (2014). Genome-wide association study of alcohol dependence: significant findings in African- and European-Americans including novel risk loci. Mol Psychiatry 19: 41-49.
17. George SR, Roldan L, Lui A, Naranjo CA (1991). Endogenous opioids are involved in the genetically determined high preference for ethanol consumption. Alcohol Clin Exp Res 15: 668-672.
18. Gika HG, Ji C, Theodoridis GA, Michopoulos F, Kaplowitz N, Wilson ID (2012). Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A 1259: 128-137.
19. Goldstein RZ, Volkow ND (2011). Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12: 652-669.
20. Howland JG, Taepavarapruk P, Phillips AG (2002). Glutamate receptor-dependent modulation of dopamine efflux in the nucleus accumbens by basolateral, but not central, nucleus of the amygdala in rats. J Neurosci 22: 1137-1145.
21. Imperato A, Di Chiara G (1986). Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239: 219-228.
22. Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E et al (2013). Increased brain uptake and oxidation of acetate in heavy drinkers. J Clin Invest 123: 1605-1614.
23. Kaddurah-Daouk R, Krishnan KRR (2009). Metabolomics: a global biochemical approach to the study of central nervous system diseases. Neuropsychopharmacology 34: 173-186.
24. Kanehisa M (2002). The KEGG database. Novartis Found Symp 247: 91-101, discussion 101-103, 119-128, 244-252.
25. Kasanetz F, Lafourcade M, Deroche-Gamonet V, Revest J-M, Berson N, Balado E et al (2012). Prefrontal synaptic markers of cocaine addiction-like behavior in rats. Mol Psychiatry 18: 729-737.
26. Koob GF (2013). Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci 13: 3-30.
27. Koob GF, Volkow ND (2010). Neurocircuitry of addiction. Neuropsychopharmacology 35: 217-238.
28. Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK et al (2006). Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31: 1574-1582.
29. Macey DJ, Schulteis G, Heinrichs SC, Koob GF (1996). Time-dependent quantifiable withdrawal from ethanol in the rat: effect of method of dependence induction. Alcohol 13: 163-170.
30. Marinelli PW, Bai L, Quirion R, Gianoulakis C (2005). A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration. Alcohol Clin Exp Res 29: 1821-1828.
31. Masuo Y, Imai T, Shibato J, Hirano M, Jones OA, Maguire ML et al (2009). Omic analyses unravels global molecular changes in the brain and liver of a rat model for chronic Sake (Japanese alcoholic beverage) intake. Electrophoresis 30: 1259-1275.
32. Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, Harris RA (2002). Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 81: 802-813.
33. Meinhardt MW, Sommer WH (2014). The postdependent state in rats as a model for medication development in alcoholism. Addict Biol (doi:10.1111/adb.12187; e-pub ahead of print).
34. Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M et al (2013). Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. J Neurosci 33: 2794-2806.
35. Noori HR, Spanagel R, Hansson AC (2012). Neurocircuitry for modeling drug effects. Addict Biol 17: 827-864.
36. Parsons MP, Li S, Kirouac GJ (2007). Functional and anatomical connection between the paraventricular nucleus of the thalamus and dopamine fibers of the nucleus accumbens. J Comp Neurol 500: 1050-1063.
37. Pasikanti KK, Ho PC, Chan ECY (2008). Gas chromatography/mass spectrometry in metabolic profiling of biological fluids. J Chromatogr B Analyt Technol Biomed Life Sci 871: 202-211.
38. Patti GJ, Yanes O, Siuzdak G (2012). Innovation: metabolomics: the apogee of the omics trilogy. Nat Rev Mol Cell Biol 13: 263-269.
39. Paxinos G, Watson C (1998). The Rat Brian in Stereotaxic Coordinates. Academic Press: San Diego.
40. Pontieri FE, Tanda G, Di Chiara G (1995). Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proc Natl Acad Sci USA 92: 12304-12308.
41. Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J (2009). Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373: 2223-2233.
42. Reimers M, Heilig M, Sommer WH (2005). Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data. Methods 37: 219-228.
43. Rimondini R, Arlinde C, Sommer W, Heilig M (2002). Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J 16: 27-35.
44. Rimondini R, Sommer W, Heilig M (2003). A temporal threshold for induction of persistent alcohol preference: behavioral evidence in a rat model of intermittent intoxication. J Stud Alcohol 64: 445-449.
45. Sévin DC, Sauer U (2014). Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli. Nat Chem Biol 10: 266-272.
46. Sommer W, Arlinde C, Heilig M (2005). The search for candidate genes of alcoholism: evidence from expression profiling studies. Addict Biol 10: 71-79.
47. Sommer W, Hyytiä P, Kiianmaa K (2006). The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking. Addict Biol 11: 289-309.
48. Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS et al (2008). Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biol Psychiatry 63: 139-145.
49. Spanagel R (2009). Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 89: 649-705.
50. Spanagel R, Durstewitz D, Hansson A, Heinz A, Kiefer F, Köhr G et al (2013). A systems medicine research approach for studying alcohol addiction. Addict Biol 18: 883-896.
51. Storey JD, Tibshirani R (2003). Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100: 9440-9445.
52. Treutlein J, Kissling C, Frank J, Wiemann S, Dong L, Depner M et al (2006). Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Mol Psychiatry 11: 594-602.
53. Urcelay GP, Dalley JW (2011). Linking ADHD, impulsivity, and drug abuse: a neuropsychological perspective. Curr Top Behav Neurosci 9: 173-197.
54. Volkow ND, Kim SW, Wang G-J, Alexoff D, Logan J, Muench L et al (2013). Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain. Neuroimage 64: 277-283.
55. Volkow ND, Wang G-J, Franceschi D, Fowler JS, Thanos PPK, Maynard L et al (2006). Low doses of alcohol substantially decrease glucose metabolism in the human brain. Neuroimage 29: 295-301.
56. Wang J, Du H, Jiang L, Ma X, de Graaf RA, Behar KL et al (2013). Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure. Proc Natl Acad Sci USA 110: 14444-14449.
57. Weiss F, Parsons LH, Schulteis G, Hyytiä P, Lorang MT, Bloom FE et al (1996). Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci 16: 3474-3485.
58. Yang L, Sun ZS, Zhu Y (2007). Proteomic analysis of rat prefrontal cortex in three phases of morphine-induced conditioned place preference. J Proteome Res 6: 2239-2247.
59. Yao JK, Reddy RD (2005). Metabolic investigation in psychiatric disorders. Mol Neurobiol 31: 193-203.
60. Zaitsu K, Miyawaki I, Bando K, Horie H, Shima N, Katagi M et al (2013). Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine, methamphetamine, and cocaine-induced conditioned place preference. Anal Bioanal Chem 406: 1339-1354.
61. Zhou Z, Karlsson C, Liang T, Xiong W, Kimura M, Tapocik JD et al (2013). Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. Proc Natl Acad Sci USA 110: 16963-16968.
62. Zimatkin SM, Oganesian NA, Kiselevski YV, Deitrich RA (2011). Acetate-dependent mechanisms of inborn tolerance to ethanol. Alcohol Alcohol 46: 233-238.