Medulloblastoma subgroups remain stable across primary and metastatic compartments

Acta Neuropathologica

Volumn 129, Issue 3, 2015, Pages 449-457

  Wang, Xin ^a,b   Dubuc, Adrian M ^a,b   Ramaswamy, Vijay ^a,b   Mack, Stephen ^a,b   Gendoo, Deena M A ^c   Remke, Marc ^a,b   Wu, Xiaochong ^a   Garzia, Livia ^a   Luu, Betty ^a   Cavalli, Florence ^a   Peacock, John ^a,b   López, Borja ^a   Skowron, Patryk ^a,b   Zagzag, David ^d   Lyden, David ^e   Hoffman, Caitlin ^a   Cho, Yoon Jae ^f   Eberhart, Charles ^g   MacDonald, Tobey ^h   Li, Xiao Nan ⁱ   Van Meter, Timothy ^j   Northcott, Paul A ^k   Haibe Kains, Benjamin ^b,c   Hawkins, Cynthia ^a   Rutka, James T ^a   Bouffet, Eric ^a   Pfister, Stefan M ^k   Korshunov, Andrey ^l   Taylor, Michael D ^a   more..

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^l GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

more..

Author keywords

DNA methylation; Gene expression; Integrative genomics; Medulloblastoma; Metastasis; Molecular subgroups

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONSENSUS; DNA METHYLATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MEDULLOBLASTOMA; METASTASIS; METHYLATION; PRIMARY TUMOR; PRIORITY JOURNAL; STAINING; CEREBELLUM TUMOR; CLUSTER ANALYSIS; DNA MICROARRAY; GENETICS; PATHOLOGY; PRESCHOOL CHILD;

TRANSCRIPTOME;

ADOLESCENT; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; FEMALE; HUMANS; MALE; MEDULLOBLASTOMA; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSCRIPTOME;

EID: 84925483142     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1389-0     Document Type: Article

References (31)

1. Brunet J-P, Tamayo P, Golub TR, Mesirov JP (2004) Metagenes and molecular pattern discovery using matrix factorization. Proc Natl Acad Sci 101:4164–4169. doi:10.1073/pnas.0308531101
2. Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG et al (2011) Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol 29:1424–1430
3. Dolecek TA, Propp JM, Stroup NE, Kruchko C (2012) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005–2009. Neuro Oncol 14(Suppl 5):v1–v49. doi:10.1093/neuonc/nos218
4. Gandola L, Massimino M, Cefalo G et al (2009) Hyperfractionated accelerated radiotherapy in the Milan strategy for metastatic medulloblastoma. J Clin Oncol 27:566–571. doi:10.1200/JCO.2008.18.4176
5. Gibson P, Tong Y, Robinson G et al (2010) Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095–1099. doi:10.1038/nature09587
6. Hovestadt V, Jones DTW, Picelli S et al (2014) Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature 510:537–541. doi:10.1038/nature13268
7. Hovestadt V, Remke M, Kool M et al (2013) Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays. Acta Neuropathol 125:913–916. doi:10.1007/s00401-013-1126-5
8. Irizarry RA (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:15e. doi:10.1093/nar/gng015
9. Jakacki RI, Burger PC, Zhou T et al (2012) Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: a Children’s Oncology Group Phase I/II study. J Clin Oncol 30:2648–2653. doi:10.1200/JCO.2011.40.2792
10. Johnson BE, Mazor T, Hong C et al (2014) Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343:189–193. doi:10.1126/science.1239947
11. Kawauchi D, Robinson G, Uziel T et al (2012) A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21:168–180. doi:10.1016/j.ccr.2011.12.023
12. Kool M, Korshunov A, Remke M et al (2012) Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. doi:10.1007/s00401-012-0958-8
13. Kool M, Koster J, Bunt J et al (2008) Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 3:e3088. doi:10.1371/journal.pone.0003088
14. Northcott PA, Shih DJH, Remke M et al (2012) Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. Acta Neuropathol 123:615–626. doi:10.1007/s00401-011-0899-7
15. Northcott PA, Jones DTW, Kool M et al (2012) Medulloblastomics: the end of the beginning. Nat Rev Cancer 12:818–834. doi:10.1038/nrc3410
16. Northcott PA, Korshunov A, Witt H et al (2011) Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 29:1408–1414. doi:10.1200/JCO.2009.27.4324
17. Packer RJ, Gajjar A, Vezina G et al (2006) Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 24:4202–4208. doi:10.1200/JCO.2006.06.4980
18. Patel AP, Tirosh I, Trombetta JJ et al (2014) Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344:1396–1401. doi:10.1126/science.1254257
19. Pei Y, Moore CE, Wang J et al (2012) An animal model of MYC-driven medulloblastoma. Cancer Cell 21:155–167. doi:10.1016/j.ccr.2011.12.021
20. Polkinghorn WR, Tarbell NJ (2007) Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification. Nat Clin Pract Oncol 4:295–304. doi:10.1038/ncponc0794
21. Ramaswamy V, Northcott PA, Taylor MD (2011) FISH and chips: the recipe for improved prognostication and outcomes for children with medulloblastoma. Cancer Genet 204:577–588. doi:10.1016/j.cancergen.2011.11.001
22. Ramaswamy V, Remke M, Bouffet E et al (2013) Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. Lancet Oncol 14:1200–1207. doi:10.1016/S1470-2045(13)70449-2
23. Remke M, Hielscher T, Korshunov A et al (2011) FSTL5 is a marker of poor prognosis in non-WNT/Non-SHH medulloblastoma. J Clin Oncol 29:3852–3861. doi:10.1200/JCO.2011.36.2798
24. Remke M, Hielscher T, Northcott PA et al (2011) Adult medulloblastoma comprises three major molecular variants. J Clin Oncol 29:2717–2723. doi:10.1200/JCO.2011.34.9373
25. Sottoriva A, Spiteri I, Piccirillo SGM et al (2013) Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci 110:4009–4014. doi:10.1073/pnas.1219747110
26. Tarbell NJ, Friedman H, Polkinghorn WR et al (2013) High-risk medulloblastoma: a pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031). J Clin Oncol 31:2936–2941. doi:10.1200/JCO.2012.43.9984
27. Taylor MD, Northcott PA, Korshunov A et al (2012) Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 123:465–472. doi:10.1007/s00401-011-0922-z
28. Thompson MC, Fuller C, Hogg TL et al (2006) Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 24:1924–1931. doi:10.1200/JCO.2005.04.4974
29. Tibshirani R, Hastie T, Narasimhan B, Chu G (2002) Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci 99:6567–6572. doi:10.1073/pnas.082099299
30. Wang X, Ramaswamy V, Remke M et al (2013) Intertumoral and intratumoral heterogeneity as a barrier for effective treatment of medulloblastoma. Neurosurgery 60(Suppl 1):57–63. doi:10.1227/01.neu.0000430318.01821.6f
31. Wu X, Northcott PA, Dubuc A et al (2012) Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482:529–533. doi:10.1038/nature10825