Recurrence patterns across medulloblastoma subgroups: An integrated clinical and molecular analysis

The Lancet Oncology

Volumn 14, Issue 12, 2013, Pages 1200-1207

  Ramaswamy, Vijay ^a,b   Remke, Marc ^a,b   Bouffet, Eric ^a   Faria, Claudia C ^a,c   Perreault, Sebastien ^d   Cho, Yoon Jae ^d   Shih, David J ^a,b   Luu, Betty ^a   Dubuc, Adrian M ^a,b   Northcott, Paul A ^e   Schüller, Ulrich ^f   Gururangan, Sridharan ^g   McLendon, Roger ^g   Bigner, Darell ^g   Fouladi, Maryam ^h   Ligon, Keith L ^i,k,l   Pomeroy, Scott L ^j,m   Dunn, Sandra ⁿ   Triscott, Joanna ⁿ   Jabado, Nada ^o   Fontebasso, Adam ^o   Jones, David T W ^e   Kool, Marcel ^e   Karajannis, Matthias A ^p   Gardner, Sharon L ^p   Zagzag, David ^p,q   Nunes, Sofia ^r   Pimentel, José ^c   Mora, Jaume ^s   Lipp, Eric ^g   Walter, Andrew W ^t   Ryzhova, Marina ^u   Zheludkova, Olga ^v   Kumirova, Ella ^v   Alshami, Jad ^o   Croul, Sidney E ^a   Rutka, James T ^a,b   Hawkins, Cynthia ^a   Tabori, Uri ^a   Codispoti, Kari Elise T ^w   Packer, Roger J ^w   Pfister, Stefan M ^e,x   Korshunov, Andrey ^e,y   Taylor, Michael D ^a,b   more..

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL DE SANTA MARIA   (Portugal)

^d STANFORD UNIVERSITY   (United States)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^f UNIVERSITY OF MUNICH   (Germany)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j MASSACHUSETTS GENERAL HOSPITAL   (United States)

^k BOSTON CHILDREN S HOSPITAL   (United States)

^l DANA FARBER CANCER INSTITUTE   (United States)

^m BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁿ BC CHILDREN S HOSPITAL   (Canada)

^o MONTREAL CHILDREN S HOSPITAL   (Canada)

^p NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^q NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^s HOSPITAL SANT JOAN DE DÉU   (Spain)

^t NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^u BURDENKO NEUROSURGICAL INSTITUTE   (Russian Federation)

^v DMITRY ROGACHEV NATIONAL MEDICAL RESEARCH CENTER OF PEDIATRIC HEMATOLOGY   (Russian Federation)

^w CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^x UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^y UNIVERSITY OF HEIDELBERG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; ETOPOSIDE; FORMALDEHYDE; PARAFFIN; TEMOZOLOMIDE;

ADOLESCENT; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CANADA; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; CRANIOSPINAL IRRADIATION; FEMALE; HUMAN; HUMAN TISSUE; LONG TERM SURVIVAL; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RUSSIAN FEDERATION; SCHOOL CHILD; TUMOR LOCALIZATION; TUMOR RECURRENCE;

ADOLESCENT; CANADA; CEREBELLAR NEOPLASMS; CHILD; CHILD, PRESCHOOL; EUROPE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MEDULLOBLASTOMA; NEOPLASM RECURRENCE, LOCAL; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; UNITED STATES;

EID: 84886725191     PISSN: 14702045     EISSN: 14745488     Source Type: Journal    
DOI: 10.1016/S1470-2045(13)70449-2     Document Type: Article

References (32)

1. Ramaswamy V, Northcott PA, Taylor MD FISH and chips: the recipe for improved prognostication and outcomes for children with medulloblastoma. Cancer Genet 2011, 204:577-588.
2. Northcott PA, Jones DT, Kool M, et al. Medulloblastomics: the end of the beginning. Nat Rev Cancer 2012, 12:818-834.
3. Packer RJ, Gajjar A, Vezina G, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 2006, 24:4202-4208.
4. Gajjar A, Chintagumpala M, Ashley D, et al. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol 2006, 7:813-820.
5. Tarbell NJ, Friedman H, Polkinghorn WR, et al. High-risk medulloblastoma: a pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031). J Clin Oncol 2013, 31:2936-2941.
6. Pizer B, Donachie PH, Robinson K, et al. Treatment of recurrent central nervous system primitive neuroectodermal tumours in children and adolescents: results of a Children's Cancer and Leukaemia Group study. Eur J Cancer 2011, 47:1389-1397.
7. Taylor MD, Northcott PA, Korshunov A, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 2012, 123:465-472.
8. Dubuc AM, Morrissy AS, Kloosterhof NK, et al. Subgroup-specific alternative splicing in medulloblastoma. Acta Neuropathol 2012, 123:485-499.
9. Remke M, Hielscher T, Korshunov A, et al. FSTL5 Is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. J Clin Oncol 2011, 29:3852-3861.
10. Remke M, Hielscher T, Northcott PA, et al. Adult medulloblastoma comprises three major molecular variants. J Clin Oncol 2011, 29:2717-2723.
11. Jones DT, Jager N, Kool M, et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 2012, 488:100-105.
12. Kool M, Korshunov A, Remke M, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, group 3, and group 4 medulloblastomas. Acta Neuropathol 2012, 123:473-484.
13. Northcott PA, Shih DJ, Peacock J, et al. Subgroup-specific structural variation across 1000 medulloblastoma genomes. Nature 2012, 488:49-56.
14. Northcott PA, Shih DJ, Remke M, et al. Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. Acta Neuropathol 2012, 123:615-626.
15. Pugh TJ, Weeraratne SD, Archer TC, et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 2012, 488:106-110.
16. Wu X, Northcott PA, Dubuc A, et al. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 2012, 482:529-533.
17. Northcott PA, Korshunov A, Witt H, et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011, 29:1408-1414.
18. Robinson G, Parker M, Kranenburg TA, et al. Novel mutations target distinct subgroups of medulloblastoma. Nature 2012, 488:43-48.
19. Sottoriva A, Spiteri I, Piccirillo SG, et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci USA 2013, 110:4009-4014.
20. Phillips HS, Kharbanda S, Chen R, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006, 9:157-173.
21. Pei Y, Moore CE, Wang J, et al. An animal model of MYC-driven medulloblastoma. Cancer Cell 2012, 21:155-167.
22. Kawauchi D, Robinson G, Uziel T, et al. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 2012, 21:168-180.
23. Gibson P, Tong Y, Robinson G, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 2010, 468:1095-1099.
24. Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, Mesirov JP GenePattern 2.0. Nat Genet 2006, 38:500-501.
25. Pfister S, Remke M, Benner A, et al. Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J Clin Oncol 2009, 27:1627-1636.
26. Korshunov A, Remke M, Werft W, et al. Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification. J Clin Oncol 2010, 28:3054-3060.
27. Ellison DW, Kocak M, Dalton J, et al. Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables. J Clin Oncol 2011, 29:1400-1407.
28. Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012, 366:883-892.
29. Aparicio S, Caldas C The implications of clonal genome evolution for cancer medicine. N Engl J Med 2013, 368:842-851.
30. Warmuth-Metz M, Blashofer S, Bueren AO, et al. Recurrence in childhood medulloblastoma. J Neurooncol 2010, 103:705-711.
31. Tabori U, Sung L, Hukin J, et al. Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma. Int J Radiat Oncol Biol Phys 2006, 64:402-407.
32. Korshunov A, Benner A, Remke M, Lichter P, von Deimling A, Pfister S Accumulation of genomic aberrations during clinical progression of medulloblastoma. Acta Neuropathol 2008, 116:383-390.