Combination treatment of biomechanical support and targeted intra-arterial infusion of peripheral blood stem cells mobilized by granulocyte-colony stimulating factor for the osteonecrosis of the femoral head: A randomized controlled clinical trial

Journal of Bone and Mineral Research

Volumn 30, Issue 4, 2015, Pages 647-656

  Mao, Qiang ^a,b   Wang, Weidong ^b   Xu, Taotao ^a,b,c   Zhang, Shanxing ^a,b   Xiao, Luwei ^a,b,c   Chen, Di ^d   Jin, Hongting ^b,c   Tong, Peijian ^a,b,c  

^a THE FIRST AFFILIATED HOSPITAL OF ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^c Institute of Orthopaedics and Traumatology of Zhejiang Province   (China)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Granulocyte colony Stimulating Factor; Intra arterial Delivery; Medial Circumflex Femoral Artery; Osteonecrosis of rhe Femoral Head; Peripheral Blood Stem Cells

Indexed keywords

ANTIBIOTIC AGENT; GRANULOCYTE COLONY STIMULATING FACTOR; TANTALUM;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; ASSESSMENT OF HUMANS; ASSOCIATION RESEARCH CIRCULATION OSSEOUS; BIOMECHANICS; CONTROLLED STUDY; DISEASE COURSE; FEASIBILITY STUDY; FEMALE; FEMUR HEAD NECROSIS; FEMUR PROSTHESIS; FOLLOW UP; HARRIS HIP SCORE; HUMAN; MAJOR CLINICAL STUDY; MALE; METAL IMPLANT; PARALLEL DESIGN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; POROUS TANTALUM ROD; POSTOPERATIVE INFECTION; PROSTHESIS DISLOCATION; RANDOMIZED CONTROLLED TRIAL; STEM CELL MOBILIZATION; SURVIVAL TIME; TOTAL HIP PROSTHESIS; INTRAARTERIAL DRUG ADMINISTRATION; MIDDLE AGED; MULTIMODALITY CANCER THERAPY;

ADULT; BIOMECHANICAL PHENOMENA; COMBINED MODALITY THERAPY; FEMALE; FEMUR HEAD NECROSIS; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION;

EID: 84925445191     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2390     Document Type: Article

References (61)

1. Wen Q, Ma L, Chen YP, Yang L, Luo W, Wang XN,. Treatment of avascular necrosis of the femoral head by hepatocyte growth factor-transgenic bone marrow stromal stem cells. Gene Ther. 2008; 15 (23): 1523-35.
2. Fan M, Peng J, Qin L, Lu S,. Experimental animal models of osteonecrosis. Rheumatol Int. 2011; 31 (8): 983-94.
3. Lieberman JR, Engstrom SM, Meneghini RM, SooHoo NF,. Which factors influence preservation of the osteonecrotic femoral head. Clin Orthop Relat Res. 2012; 470 (2): 525-34.
4. Aaron RK,. Osteonecrosis: etiology, pathophysiology and diagnosis. In:, Callaghan JJ, Rosenberg AG, Rubash HE, editor. The adult hip. Philadelphia: Lippincott-Raven; 1998. p. 451-66.
5. Lieberman JR, Berry DJ, Mont MA, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect. 2003; 52: 337-55.
6. Cardozo JB, Andrade DM, Santiago MB,. The use of bisphosphonate in the treatment of avascular necrosis: a systematic review. Clin Rheumatol. 2008; 27 (6): 685-8.
7. Hernigou P, Zilber S, Filippini P, Rouard H, Methieu G, Poignard A,. Bone marrow injection in hip osteonecrosis. Tech Orthop. 2008; 23: 18-25.
8. Li W, Sakai T, Nishii T, et al. Distribution of TRAP-positive cells and expression of HIF- 1alpha, VEGF, and FGF-2 in the reparative reaction in patients with osteonecrosis of the femoral head. J Orthop Res. 2009; 27 (5): 694-700.
9. Zhao D, Cui D, Wang B, et al. Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells. Bone. 2012; 50 (1): 325-30.
10. Gangji V, De Maertelaer V, Hauzeur JP,. Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study. Bone. 2011; 49 (5): 1005-9.
11. Xie XH, Wang XL, He YX, et al. Promotion of bone repair by implantation of cryopreserved bone marrow-derived mononuclear cells in a rabbit model of steroid-associated osteonecrosis. Arthritis Rheum. 2012; 64 (5): 1562-71.
12. Cui Q, Botchwey EA,. Treatment of precollapse osteonecrosis using stem cells and growth factors. Clin Orthop Relat Res. 2011; 469 (9): 2665-9.
13. Mao Q, Jin H, Liao F, Xiao L, Chen D, Tong P,. The efficacy of targeted intraarterial delivery of concentrated autologous bone marrow containing mononuclear cells in the treatment of osteonecrosis of the femoral head: a five year follow-up study. Bone. 2013; 57 (2): 509-16.
14. Rackwitz L, Eden L, Reppenhagen S, et al. Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head. Stem Cell Res Ther. 2012; 3 (1): 7.
15. Yan Z, Hang D, Guo C, Chen Z,. Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J Orthop Res. 2009; 27 (4): 442-6.
16. Elliott MJ, De Coppi P, Speggiorin S, et al. Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study. Lancet. 2012; 380 (9846): 994-1000.
17. Kang HJ, Kim HS, Zhang SY, et al. Effects of intracoronary infusion of peripheral blood stem- cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet. 2004; 363 (9411): 751-6.
18. Hsieh MM, Kang EM, Fitzhugh CD, et al. Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. N Engl J Med. 2009; 361 (24): 2309-17.
19. Song HJ, Lan BS, Cheng B, et al. Peripheral blood stem cell transplantation for ischemic femoral head necrosis. Transplant Proc. 2010; 42 (5): 1862-4.
20. Song HJ, Lan BS, Cheng B, et al. Treatment of early avascular necrosis of femoral head by small intestinal submucosal matrix with peripheral blood stem cells. Transplant Proc. 2011; 43 (5): 2027-32.
21. Tse HF, Kwong YL, Chan JKF, Lo G, Ho CL, Lau CP,. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet. 2003; 361 (9351): 47-9.
22. Kajiguchi M, Kondo T, Izawa H, et al. Safety,efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia. Circ J. 2007; 71 (2): 196-201.
23. Nevskaya T, Ananieva L, Bykovskaia S, et al. Autologous progenitor cell implantation as a novel therapeutic intervention for ischaemic digits in systemic sclerosis. Rheumatology (Oxford). 2009; 48 (1): 61-4.
24. Iwasaki H, Fukushima K, Kawamoto A, et al. Synchrotron radiation coronary microangiography for morphometric and physiological evaluation of myocardial neovascularization induced by endothelial progenitor cell transplantation. Arterioscler Thromb Vasc Biol. 2007; 27 (6): 1326-33.
25. Wen Y, Meng L, Ding Y, Ouyang J,. Autologous transplantation of blood-derived stem progenitor cells for ischaemic heart disease. Int J Clin Pract. 2011; 65 (8): 858-65.
26. Dubsky M, Jirkovska A, Bem R, et al. Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment. Diabetes Metab Res Rev. 2013; 29 (5): 369-76.
27. Zhang Y, Li L, Shi ZJ, Wang J, Li ZH,. Porous tantalum rod implant is an effective and safe choice for early-stage femoral head necrosis: a meta-analysis of clinical trials. Eur J Orthop Surg Traumatol 2013; 23 (2): 211-7.
28. Yang S, Wu X, Xu W, Ye S, Liu X, Liu X,. Structural augmentation with biomaterial loaded allograft threaded cage for the treatment of femoral head osteonecrosis. J Arthroplasty. 2010; 25 (8): 1223-30.
29. Floerkemeier T, Thorey F, Daentzer D, et al. Clinical and radiological outcome of the treatment of osteonecrosis of the femoral head using the osteonecrosis intervention implant. Int Orthop. 2011; 35 (4): 489-95.
30. Malizos KN, Papasoulis E, Dailiana ZH, Papatheodorou LK, Varitimidis SE,. Early results of a novel technique using multiple small tantalum pegs for the treatment of osteonecrosis of the femoral head: a case series involving 26 hips. J Bone Joint Surg Br. 2012; 94 (2): 173-8.
31. Liu G, Wang J, Yang S, Xu W, Ye S, Xia T,. Effect of a porous tantalum rod on early and intermediate stages of necrosis of the femoral head. Biomed Mater. 2010; 5 (6): 065003.
32. Floerkemeier T, Lutz A, Nackenhorst U, et al. Core decompression and osteonecrosis intervention rod in osteonecrosis of the femoral head: clinical outcome and finite element analysis. Int Orthop. 2011; 35 (10): 1461-6.
33. Varitimidis SE, Dimitroulias AP, Karachalios TS, Dailiana ZH, Malizos KN,. Outcome after tantalum rod implantation for treatment of femoral head osteonecrosis: 26 hips followed for an average of 3 years. Acta Orthop. 2009; 80 (1): 20-5.
34. Chen CC, Lin CL, Chen WC, Shih HN, Ueng SW, Lee MS,. Vascularized iliac bone-grafting for osteonecrosis with segmental collapse of the femoral head. J Bone Joint Surg Am. 2009; 91 (10): 2390-4.
35. Seyler TM, Marker DR, Ulrich SD, Fatscher T, Mont MA,. Nonvascularized bone grafting defers joint arthroplasty in hip osteonecrosis. Clin Orthop Relat Res. 2008; 466 (5): 1125-32.
36. Yoo MC, Kim KI, Hahn CS, Parvizi J,. Long-term followup of vascularized fibular grafting for femoral head necrosis. Clin Orthop Relat Res. 2008; 466 (5): 1133-40.
37. Yuhan C, Hu CC, Chen DW, Ueng SW, Shih CH, Lee MS,. Local cancellous bone grafting for osteonecrosis of the femoral head. Surg Innov. 2009; 16 (1): 63-7.
38. Wang BL, Sun W, Shi ZC, et al. Treatment of nontraumatic osteonecrosis of the femoral head using bone impaction grafting through a femoral neck window. Int Orthop. 2010; 34 (5): 635-9.
39. Shih LY, Wong YC, Shih HN,. One-stage hip arthroplasty and bone grafting for bilateral femoral head osteonecrosis. Clin Orthop Relat Res. 2009; 467 (6): 1522-8.
40. Mont MA, Marulanda GA, Jones LC, et al. Systematic analysis of classification systems for osteonecrosis of the femoral head. J Bone Joint Surg Am. 2006; 88 (Suppl 3): 16-26.
41. Costa ML, Achten J, Parsons NR, et al. Young Adult Hip Arthroplasty Team. Total hip arthroplasty versus resurfacing arthroplasty in the treatment of patients with arthritis of the hip joint: single centre,parallel group,assessor blinded,randomised controlled trial. BMJ. 2012; 19 (344): e2147.
42. The COBE Spectra Apheresis System Operator's Manual. Lakewood, CO: COBE BCT; 1999.
43. Agarwala S, Shah S, Joshi VR,. The use of alendronate in the treatment of avascular necrosis of the femoral head: follow-up to eight years. J Bone Joint Surg Br. 2009; 91 (8): 1013-8.
44. Shuler MS, Rooks MD, Roberson JR,. Poroustantalum implant in early osteonecrosis of the hip: preliminary report on operative, survival, and outcomes results. J Arthroplasty. 2007; 22 (1): 26-31.
45. Lai KA, Shen WJ, Yang CY, Shao CJ, Hsu JT, Lin RM,. The use of alendronate to prevent early collapse of femoral head in patients with nontraumatic osteonecrosis: a randomized clinical study. J Bone Joint Surg Am. 2005; 87 (10): 2155-9.
46. Liu B, Sun W, Yue D, Li Z, Guo W,. Combined tantalum implant with bone grafting for the treatment of osteonecrosis of the femoral head. J Invest Surg. 2013; 26 (3): 158-62.
47. Alves EM, Angrisani AT, Santiago MB,. The use of extracorporeal shock waves in the treatment of osteonecrosis of the femoral head: a systematic review. Clin Rheumatol. 2009; 28 (11): 1247-51.
48. Veillette CJ, Mehdian H, Schemitsch EH, McKee MD,. Survivorship analysis and radiographic outcome following tantalum rod insertion for osteonecrosis of the femoral head. J Bone Joint Surg Am. 2006; 88 (Suppl 3): 48-55.
49. Tsao AK, Roberson JR, Christie MJ, et al. Biomechanical and clinical evaluations of a porous tantalum implant for the treatment of early-stage osteonecrosis. J Bone Joint Surg Am. 2005; 87 (Suppl 2): 22-7.
50. Tanzer M, Karabasz D, Krygier JJ, Cohen R, Bobyn JD,. Bone augmentation around and within porous implants by local bisphosphonate elution. Clin Orthop Relat Res. 2005; 441: 30-9.
51. Shimko DA, Shimko VF, Sander EA, Dickson KF, Nauman EA,. Effect of porosity on the fluid flow characteristics and mechanical properties of tantalum scaffolds. J Biomed Mater Res B Appl Biomater. 2005; 73 (2): 315-24.
52. Tanzer M, Bobyn JD, Krygier JJ, Karabasz D,. Histopathologic retrieval analysis of clinically failed porous tantalum osteonecrosis implants. J Bone Joint Surg Am. 2008; 90 (6): 1282-9.
53. Feng Y, Yang SH, Xiao BJ, et al. Decreased in the number and function of circulation endothelial progenitor cells in patients with avascular necrosis of the femoral head. Bone. 2010; 46 (1): 32-40.
54. Jansen J, Hanks S, Thompson JM,. Transplantation of hematopoietic stem cells from the peripheral blood. J Cell Mol Med. 2005; 9: 37.
55. Lie AK, To LB,. Peripheral blood stem cells: transplantation and beyond. Oncologist. 1997; 2 (1): 40-9.
56. To LB, Haylock DN, Simmons PJ, Juttner CA,. The biology and clinical uses of blood stem cells. Blood. 1997; 89 (7): 2233-58.
57. Shyu WC, Lin SZ, Chiang MF, Su CY, Li H,. Intracerebral peripheral blood stem cell (CD34) implantation induces neuroplasticity by enhancing β1 integrin-mediated angiogenesis in chronic stroke rats. J Neurosci 2006; 26 (13): 3444-53.
58. Georgantas RW, 3rd, Hildreth R, Morisot S, et al. CD34+ hematopoietic stem-progenitor cell microRNA expression,function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A. 2007; 104 (8): 2750-5.
59. Chamberlain G, Fox J, Ashton B, Middleton J,. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007; 25 (11): 2739-49.
60. Yagi H, Soto-Gutierrez A, Parekkadan B, et al. Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplant. 2010; 19 (6): 667-79.
61. Li ZH, Liao W, Cui XL, et al. Intravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head. Int J Med Sci. 2011; 8 (1): 74-83.