Treatment of avascular necrosis of the femoral head by hepatocyte growth factor-transgenic bone marrow stromal stem cells

Gene Therapy

Volumn 15, Issue 23, 2008, Pages 1523-1535

  Wen, Q ^a   Ma, L ^a   Chen, Y P ^b   Yang, L ^b   Luo, W ^a   Wang, X N ^c  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b FIRST MILITARY MEDICAL UNIVERSITY   (China)

^c SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; FIBRINOGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; SCATTER FACTOR;

ANGIOGENESIS; ANGIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVASCULAR NECROSIS; BONE REGENERATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EXPERIMENTAL RABBIT; FEMUR HEAD NECROSIS; GENETIC TRANSFECTION; GUIDED IMAGERY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STEM CELL GENE THERAPY; STROMA CELL; TRANSGENICS;

ADENOVIRIDAE; ANIMALS; BONE REGENERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMUR HEAD; FEMUR HEAD NECROSIS; FIBRINOGEN; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HEPATOCYTE GROWTH FACTOR; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; PERFUSION IMAGING; RABBITS; STAINING AND LABELING; STEM CELL TRANSPLANTATION; STROMAL CELLS; TOMOGRAPHY, X-RAY COMPUTED; TRANSDUCTION, GENETIC; TRANSGENES;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 56349106408     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2008.110     Document Type: Article

References (43)

1. Jones LC, Hungerford DS. The pathogenesis of osteonecrosis. Instr Course Lect 2007; 56: 179-196.
2. Mont MA, Jones LC, Hungerford DS. Nontraumatic osteonecrosis of the femoral head: Ten years later. J Bone Joint Surg Am 2006; 88 l1l7-1132.
3. Ito H, Matsuno T, Omizu N, Aoki Y, Minami A. Mid-term prognosis of non-traumatic osteonecrosis of the femoral head. J Bone Joint Surg Br 2003; 85: 796-801.
4. Steinberg ME, Larcom PG, Stafford BB, Hosick WB, Corces A, Bands RE el at. Treatment of osteonecrosis of the femoral head by core decompression, bone grafting and electrical stimulation. In: Urbaniak JR, Jones JP (eds). Osteonecrosis: Etiology, Diagnosis, and Treatment American Academy of Orthopaedic Surgeons: Rosemont, IL, 1997, pp 293-299.
5. Stulberg BN, Davis AW, Bauer TW, Levine M, Easley K. Osteonecrosis of the femoral head. A prospective randomized treatment protocol. Clin Orthop 1991; 268: 140-151.
6. Koo KH, Kim R, Ko GH, Song HR, Jeong ST, Cho SH. Preventing collapse in early osteonecrosis of the femoral head. A randomised clinical trial of core decompression. J Bone Joint Surg Br 1995; 77: 870-874.
7. Lieberman JR. Core decompression for osteonecrosis of the hip. Clin Orthop Relat Res 2004; 418: 29-33.
8. Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 1984; 122: 1450-1459.
9. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989; 342: 440-443.
10. Nakamura Y, Morishita R, Higaki J, Kida I, Aoki M, Moriguchi A et al Hepatocyte growth factor (HGF) is a novel member of endothelium-specific growth factors: Additive stimulatory effect of HGF with basic fibroblast growth factor, but not vascular endothelial growth factor. J Hypertens 1996; 14: 1067-1072.
11. Nakamura Y, Morishita R, Nakamura S, Aoki M, Moriguchi A, Matsumoto K et al. A vascular modulator, hepatocyte growth factor, is associated with systolic pressure. Hypertension 1996; 28: 409-413.
12. Liu Y, Sun AM, Dworkin LD. Hepatocyte growth factor protects renal epithelial cells from apoptotic cell death. Biochem Biophys Res Commun 1998; 246: 821-826.
13. Maina F, Klein R. Hepatocyte growth factor, a versatile signal for developing neurons. Nat Neurosci 1999; 2: 213-217.
14. Kosai K, Matsumoto K, Nagata S, Tsujimoto Y, Nakamura T. Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor. Biochem Biophys Res Commun 1998; 244: 683-690.
15. Kosai K, Matsumoto K, Funakoshi H, Nakamura T. Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology 1999; 30: 151-159.
16. Yo Y, Morishita R, Yamamoto K, Tomita N, Kida I, Hayashi S et al. Actions of hepatocyte growth factor as a local modulator in the kidney: potential role in pathogenesis of renal disease Kid Int 1998; 53: 50-58.
17. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147.
18. Tsuchida H, Hashimoto J, Crawford F, Manske P, Lou J. Engineered allogeneic mesenchymal stem cells repair femoral segmental defect in rats. J Orthop Res 2003; 21: 44-53.
19. Pelissier P, Villars F, Mathoulin-Pelissier S, Bareille R, Lafage-Proust MH, Vilamitjana-Amedee J. Influences of vascularization and osteogenic cells on heterotopic bone formation within a madreporic ceramic in rats. Plast Reconstr Surg 2003; 111: 932-941.
20. Deans RJ, Moseley AB. Mesenchymal stem cells: Biology and potential clinical uses. Exp Hematol 2000; 28: 875-884.
21. Bruder SP, Jaiswal N, Ricalton NS, Mosca JD, Kraus KH, Kadiyala S. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res 1998; 355: S247-S256.
22. Lee K, Majumdar MK, Buyaner D, Hendricks JK, Pittenger MF, Mosca JD. Human mesenchymal stem cells maintain transgene expression during expansion and differentiation. Mol Ther 2001; 3: 857-866.
23. Gangji V, Hauzeur JP, Matos C, De Maertelaer V, Toungouz M, Lambermont M. Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. A pilot study. J Bone Joint Surg Am 2004; 86-A: 1153-1160.
24. Saito S, Ohzono K, Ono K. Minimal osteonecrosis as a segmental infarct within the femoral head. Clin Orthop Relat Res 1988; 231: 35-50.
25. Arlet J. Nontraumatic avascular necrosis of the femoral head (past, present, and future). Clin Orthop 1992; 277: 12-21.
26. Tio RA, Tkebuchava T, Scheuermann TH, Lebherz C, Magner M, Kearny M et al. Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium. Hum Gene Ther 1999; 10: 2953-2960.
27. Hariawala MD, Horowitz JR, Esakof D, Sheriff DD, Walter DH, Keyt B et al. VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts. J Surg Res 1996; 63: 77-82.
28. Garcia-Martinez C, Opolon P, Trochon V, Chianale C, Musset K, Lu H et al. Angiogenesis induced in muscle by a recombinant adenovirus expressing functional isoforms of basic fibroblast growth factor. Gen Ther 1999; 6: 1210-1221.
29. Stella MC, Comoglio PM. HGF: A multifunctional growth factor controlling cell scattering. Int J Biochem Cell Biol 1999; 31: 1357-1362.
30. Taniyama Y, Morishita R, Aoki M, Hiraoka K, Yamasaki K, Hashiya N et al. Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy. Hypertension 2002; 40: 47-53.
31. Stuart KA, Riordan SM, Lidder S, Crostella L, Williams R, Skouteris GG. Hepatocyte growth factor/scatter factor-induced intracellular signaling. Int J Exp Pathol 2000; 81: 17-30.
32. Nakagami H, Kaneda Y, Ogihara T, Morishita R. Hepatocyte growth factor as potential cardiovascular therapy. Expert Rev Cardiovasc Ther 2005; 3: 513-519.
33. Funatsu T, Sawa Y, Ohtake S, Takahashi T, Matsumiya G, Matsuura N et al. Therapeutic angiogenesis in the ischemic canine heart induced by myocardial injection of naked complementary DNA plasmid encoding hepatocyte growth factor. J Thorac Cardiovasc Surg 2002; 124 1099-1105.
34. Wu DL, Zhang YR, Lao MF, Yuan LZh, Wang L, Ha XQ et al. Gene therapy of canine myocardial ischemia with recombinant adenovirus carrying hepatocyte growth factor. Chin Sci Bull 2004; 49: 1278-1282.
35. di Mari JF, Davis R, Safirstein RL. MAPK activation determines renal epithelial cell survival during oxiative injury. Am J Physiol 1999; 277: F195-F203.
36. Yang C, Yang ShH, Du JY, Xiao BJ, Li J, Ye ShN. To enhance the repair of avascular necrosis of the femoral head with vascular endothelial growth factor gene transfection. J Clin Orthop 2004; 7: 90-93.
37. Deans RJ, Moseley AB. Mesenchymal stem cells: Biology and potential clinical uses. Exp Hematol 2000; 28: 875-884.
38. Wang WZh, Xing GY, Zhang KCh, Ma LG, Bai XD, Li B. Treatment of avascular necrosis of femoral head by core decompression and autograft of mesenchymal stem cells. J Chin Phys 2006; 8: 436-439.
39. Hattori T. Experimental investigations of osteogenesis and chondrogenesis by implant of BMP-fibrin glue mixture. Nippon Seikeigeka Gakkai Zasshi 1990; 64: 824-834.
40. Kim NH, Yang KH, Lee HM, Oh SH. Effect of porcine bone morphogenetic protein on healing of bone defect in the rabbit radius. Yonsei Med J Mar 1992; 33: 54-63.
41. Gibble JW, Ness PM. Fibrin glue: The perfect operative sealant? Transfusion 1990; 30: 741-747.
42. Peng Songlin, Fang Huang, Chen Anming. Biocompatibility studies on fibrin glue cultured with bone marrow mesenchymal stem cells. Orthop Biomech Materials Clin Study 2004; 1: 34-37.
43. Ugai H, Yamasaki T, Hirose M, Inabe K, Kujime Y, Terashima M. Purification of infectious adenovirus in two hours by ultracentrifugation and tangential flow filtration. Biochem Biophys Res Commun 2005; 331: 1053-1060.