Investigation of new phenothiazine and carbazole derivatives as potential inhibitors of human farnesyltransferase

Letters in Drug Design and Discovery

Volumn 12, Issue 2, 2015, Pages 85-92

  Dumitriu, Gina Mirabela ^a   Ghinet, Alina ^a,b,c   Belei, Dalila ^a   Rigo, Benoît ^b,c   Gautret, Philippe ^b,c   Dubois, Joëlle ^d   Bîcu, Elena ^a  

^a ALEXANDRU IOAN CUZA UNIVERSITY OF IASI   (Romania)

^b UNIV LILLE   (France)

^c Ecole des Hautes Etudes d'Ingenieur   (France)

^d INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

Author keywords

Anticancer agent; Carbazole; Disulfide; Farnesyltransferase; Phenothiazine

Indexed keywords

2 MERCAPTOETHYL 3 (10H PHENOTHIAZIN 10 YL)PROPANOATE; 2 MERCAPTOETHYL 3 (9H CARBAZOL 9 YL)PROPANOATE; 3 (9H CARBAZOL 9YL) N (2 HYDROXYETHYL)PROPANAMIDE; 3 (9H CARBAZOL 9YL) N (2 MERCAPTOETHYL)PROPANEMIDE; BIS 2 MERCAPTOETHYL 3 (10H PHENOTHIAZIN 10 YL)PROPANOATE; BIS 3 (9H CARBAZOL 9YL) N (2 MERCAPTOETHYL)PROPANAMIDE; CARBAZOLE DERIVATIVE; MERCAPTAMINE; MERCAPTOETHANOL; N (2 HYDROXYETHYL) 3 (10H PHENOTHIAZIN 10 YL)PROPANAMIDE; N (2 MERCAPTOETHYL) 3 (10H PHENOTHIAZIN 10 YL)PROPANAMIDE; PENTAFLUOROPHENYL 3 (10H PHENOTHIAZIN 10 YL)PROPANOATE; PENTAFLUOROPHENYL 3 (9H CARBAZOL 9 YL)PROPANOATE; PHENOTHIAZINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MCF 7 CELL LINE; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

EID: 84925437735     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/1570180811666140909010435     Document Type: Article

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