Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 21, 2013, Pages 5887-5892

  Abuhaie, Cristina Maria ^a   Ghinet, Alina ^a,b,c   Farce, Amaury ^b,d   Dubois, Joëlle ^e   Rigo, Benoît ^b,c   Bîcu, Elena ^a  

^a ALEXANDRU IOAN CUZA UNIVERSITY OF IASI   (Romania)

^b UNIV LILLE   (France)

^c UNIVERSITÉ CATHOLIQUE DE LILLE   (France)

^d Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

^e INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

Author keywords

Anticancer agent; Farnesyltransferase inhibitor; N Ylide; Phenothiazine

Indexed keywords

N YLIDE DERIVATIVE; NITRILE; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTICANCER AGENT; FARNESYLTRANSFERASE INHIBITOR; N-YLIDE; PHENOTHIAZINE;

ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; HUMANS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885171740     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.088     Document Type: Article

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