Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion

Cellular Physiology and Biochemistry

Volumn 35, Issue 4, 2015, Pages 1537-1545

  Panse, Madhura ^a   Gerst, Felicia ^a   Kaiser, Gabriele ^a   Teutsch, Charlott Amélie ^a   Dölker, Rebecca ^a   Wagner, Robert ^a   Häring, Hans Ulrich ^a   Ullrich, Susanne ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Beta cell apoptosis; ERK1 2; Fatty acid receptor 1; GPR40 FFAR1; Insulin secretion; Lipotoxicity

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PALMITIC ACID; TUG 469; UNCLASSIFIED DRUG; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; ANILINE DERIVATIVE; FLAVONOID; G PROTEIN COUPLED RECEPTOR; GPR40 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PALMITIC ACID DERIVATIVE; PHENYLPROPIONIC ACID DERIVATIVE; TUG-469;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG ANTAGONISM; ENZYME ACTIVATION; INSULIN RELEASE; LIPOTOXICITY; LONG TERM EXPOSURE; NICK END LABELING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; METABOLISM; MOUSE; PHOSPHORYLATION; SECRETION (PROCESS); TUMOR CELL LINE;

ANILINE COMPOUNDS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; FLAVONOIDS; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MAP KINASE KINASE 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PALMITATES; PHENYLPROPIONATES; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84925434992     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373969     Document Type: Article

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