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Volumn 13, Issue 1, 2015, Pages

Advances in alzheimer's disease drug development

Author keywords

Alzheimer's disease; Beta amyloid; Clinical trials

Indexed keywords

CRENEZUMAB; PLACEBO; SOLANEZUMAB; 5,6 DIHYDRO 2 IMINO 3 METHYL 6 [4 [5 (1 PROPYNYL) 3 PYRIDINYL] 2 THIENYL] 4 PYRIMIDINONE; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE INHIBITOR; ENCENICLINE; GANTENERUMAB; NERVE GROWTH FACTOR; PF 4494700; PIOGLITAZONE; SARACATINIB; TAU PROTEIN; VANUTIDE CRIDIFICAR; NEUROPROTECTIVE AGENT;

EID: 84925361346     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-015-0297-4     Document Type: Review
Times cited : (86)

References (44)
  • 1
    • 84872119357 scopus 로고    scopus 로고
    • Alzheimer Disease International. The worldwide economic impact of dementia 2010
    • Wimo A, Jonsson L, Bond J, Prince M, Winblad B. Alzheimer Disease International. The worldwide economic impact of dementia 2010. Alzheimers Dement. 2013;9:1-11. e3.
    • (2013) Alzheimers Dement , vol.9 , pp. 1-11
    • Wimo, A.1    Jonsson, L.2    Bond, J.3    Prince, M.4    Winblad, B.5
  • 2
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-44.
    • (1984) Neurology. , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 3
    • 84872379077 scopus 로고    scopus 로고
    • Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
    • Jack Jr CR, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013;12:207-16.
    • (2013) Lancet Neurol. , vol.12 , pp. 207-216
    • Jack, C.R.1    Knopman, D.S.2    Jagust, W.J.3    Petersen, R.C.4    Weiner, M.W.5    Aisen, P.S.6
  • 4
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus RT. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol. 2000;163:495-529.
    • (2000) Exp Neurol. , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 5
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean 3rd RL, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science. 1982;217:408-14.
    • (1982) Science. , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 6
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P, Maloney AJ. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet. 1976;8000:1403.
    • (1976) Lancet. , vol.8000 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 7
    • 0018256391 scopus 로고
    • Evidence for a direct cholinergic involvement in the scopolamine induced amnesia in monkeys: effects of concurrent administration of physostigmine and methylphenidate with scopolamine
    • Bartus RT. Evidence for a direct cholinergic involvement in the scopolamine induced amnesia in monkeys: effects of concurrent administration of physostigmine and methylphenidate with scopolamine. Pharmacol Biochem Behav. 1978;9:833-6.
    • (1978) Pharmacol Biochem Behav. , vol.9 , pp. 833-836
    • Bartus, R.T.1
  • 10
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. 2012;488:96-9.
    • (2012) Nature. , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3    Snaedal, J.4    Jonsson, P.V.5    Bjornsson, S.6
  • 11
    • 29844434149 scopus 로고    scopus 로고
    • Anomalously phosphorylated tau protein and Abeta fragments in the CSF of Alzheimer's and MCI subjects
    • Maccioni RB, Lavados M, Maccioni CB, Mujica C, Bosch R, Farías G, et al. Anomalously phosphorylated tau protein and Abeta fragments in the CSF of Alzheimer's and MCI subjects. Neurobiol Aging. 2006;27:237-44.
    • (2006) Neurobiol Aging. , vol.27 , pp. 237-244
    • Maccioni, R.B.1    Lavados, M.2    Maccioni, C.B.3    Mujica, C.4    Bosch, R.5    Farías, G.6
  • 13
    • 84875514732 scopus 로고    scopus 로고
    • Regulatory innovation and drug development for early-stage Alzheimer's disease
    • Kozauer N, Katz R. Regulatory innovation and drug development for early-stage Alzheimer's disease. N Engl J Med. 2013;368:1169-71.
    • (2013) N Engl J Med. , vol.368 , pp. 1169-1171
    • Kozauer, N.1    Katz, R.2
  • 15
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci. 2007;8:663-72.
    • (2007) Nat Rev Neurosci. , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 16
    • 84888205849 scopus 로고    scopus 로고
    • Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
    • Braak H, Zetterberg H, Del Tredici K, Blennow K. Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol. 2013;126:631-41.
    • (2013) Acta Neuropathol. , vol.126 , pp. 631-641
    • Braak, H.1    Zetterberg, H.2    Tredici, K.3    Blennow, K.4
  • 17
    • 0031633953 scopus 로고    scopus 로고
    • Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles
    • 1691-1680
    • Iqbal K, Alonso AC, Gong CX, Khatoon S, Pei JJ, Wang JZ, et al. Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles. J Neural Transm. 1998;53:169-80.
    • (1998) J Neural Transm. , vol.53
    • Iqbal, K.1    Alonso, A.C.2    Gong, C.X.3    Khatoon, S.4    Pei, J.J.5    Wang, J.Z.6
  • 18
    • 77954033257 scopus 로고    scopus 로고
    • Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
    • Rowe CC, Ellis KA, Rimajova M, Bourgeat P, Pike KE, Jones G, et al. Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiol Aging. 2010;31:1275-83.
    • (2010) Neurobiol Aging. , vol.31 , pp. 1275-1283
    • Rowe, C.C.1    Ellis, K.A.2    Rimajova, M.3    Bourgeat, P.4    Pike, K.E.5    Jones, G.6
  • 19
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7:280-92.
    • (2011) Alzheimers Dement. , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3    Bennett, D.A.4    Craft, S.5    Fagan, A.M.6
  • 20
    • 84862767786 scopus 로고    scopus 로고
    • An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease
    • Jack Jr CR, Knopman DS, Weigand SD, Wiste HJ, Vemuri P, Lowe V, et al. An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease. Ann Neurol. 2012;71:765-75.
    • (2012) Ann Neurol. , vol.71 , pp. 765-775
    • Jack, C.R.1    Knopman, D.S.2    Weigand, S.D.3    Wiste, H.J.4    Vemuri, P.5    Lowe, V.6
  • 21
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999;400:173-7.
    • (1999) Nature. , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6
  • 22
    • 84892748542 scopus 로고    scopus 로고
    • Alzheimer's Disease Cooperative Study Steering Committee; Solanezumab study group. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease
    • Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, et al. Alzheimer's Disease Cooperative Study Steering Committee; Solanezumab study group. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N Engl J Med. 2014;370:311-21.
    • (2014) N Engl J Med , vol.370 , pp. 311-321
    • Doody, R.S.1    Thomas, R.G.2    Farlow, M.3    Iwatsubo, T.4    Vellas, B.5    Joffe, S.6
  • 23
    • 84925368907 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase 2 study to evaluate the efficacy and safety of crenezumab in patients with mild to moderate Alzheimer's disease
    • Cummings J, Cho W, Ward M, Friesenhahn M, Brunstein F, Honigberg L, et al. A randomized, double-blind, placebo-controlled phase 2 study to evaluate the efficacy and safety of crenezumab in patients with mild to moderate Alzheimer's disease. Alzheimers Demen. 2014;10:P275.
    • (2014) Alzheimers Demen , vol.10 , pp. P275
    • Cummings, J.1    Cho, W.2    Ward, M.3    Friesenhahn, M.4    Brunstein, F.5    Honigberg, L.6
  • 24
    • 84855780598 scopus 로고    scopus 로고
    • Gantenerumab: a novel human anti-beta-amyloid antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β
    • Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, et al. Gantenerumab: a novel human anti-beta-amyloid antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β. J Alzheimers Dis. 2012;28:49-69.
    • (2012) J Alzheimers Dis. , vol.28 , pp. 49-69
    • Bohrmann, B.1    Baumann, K.2    Benz, J.3    Gerber, F.4    Huber, W.5    Knoflach, F.6
  • 25
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol. 2007;8:101-12.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 26
    • 84925375243 scopus 로고    scopus 로고
    • The novel BACE inhibitor MK-8931 dramatically lowers CSF beta-amyloid peptides in healthy subjects: results from a rising single dose study (PL02. 004)
    • New Orleans: Neurology
    • Forman M, Tseng J, Palcza J, Leempoels J, Ramael S, Krishna G. The novel BACE inhibitor MK-8931 dramatically lowers CSF beta-amyloid peptides in healthy subjects: results from a rising single dose study (PL02. 004). In: 64th American Academy of Neurology Annual Meeting. New Orleans: Neurology; 2012.
    • (2012) 64th American Academy of Neurology Annual Meeting
    • Forman, M.1    Tseng, J.2    Palcza, J.3    Leempoels, J.4    Ramael, S.5    Krishna, G.6
  • 28
    • 67849102202 scopus 로고    scopus 로고
    • Anti-amyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing
    • Ryan JM, Grundman M. Anti-amyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing. J Alzheimer Dis. 2009;8:243.
    • (2009) J Alzheimer Dis. , vol.8 , pp. 243
    • Ryan, J.M.1    Grundman, M.2
  • 29
    • 34547473731 scopus 로고    scopus 로고
    • Liposomal vaccines with conformation-specific amyloid antigens define immune response and efficacy in APP transgenic mice
    • Muhs A, Hickman DT, Pihlgren M, Chuard N, Giriens N, Meerschman C, et al. Liposomal vaccines with conformation-specific amyloid antigens define immune response and efficacy in APP transgenic mice. Proc Natl Acad Sci U S A. 2007;8:9810-5.
    • (2007) Proc Natl Acad Sci U S A. , vol.8 , pp. 9810-9815
    • Muhs, A.1    Hickman, D.T.2    Pihlgren, M.3    Chuard, N.4    Giriens, N.5    Meerschman, C.6
  • 30
    • 84862331908 scopus 로고    scopus 로고
    • Safety, tolerability, and antibody response of active beta-amyloid immunotherapy with CAD106 in patients with Alzheimer's disease: randomized, double-blind, placebo-controlled, first-in-human study
    • Winblad B, Andreasen N, Minthon L, Floesser A, Imbert G, Dumortier T, et al. Safety, tolerability, and antibody response of active beta-amyloid immunotherapy with CAD106 in patients with Alzheimer's disease: randomized, double-blind, placebo-controlled, first-in-human study. Lancet Neurol. 2012;8:597-604.
    • (2012) Lancet Neurol. , vol.8 , pp. 597-604
    • Winblad, B.1    Andreasen, N.2    Minthon, L.3    Floesser, A.4    Imbert, G.5    Dumortier, T.6
  • 31
    • 76849091134 scopus 로고    scopus 로고
    • Can Alzheimer disease be prevented by amyloid-beta immunotherapy?
    • Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy? Nat Rev Neurol. 2010;6:108-19.
    • (2010) Nat Rev Neurol. , vol.6 , pp. 108-119
    • Lemere, C.A.1    Masliah, E.2
  • 32
    • 84865529158 scopus 로고    scopus 로고
    • Dominantly Inherited Alzheimer Network Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    • Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, et al. Dominantly Inherited Alzheimer Network Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med. 2012;367:795-804.
    • (2012) N Engl J Med. , vol.367 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.3    Fagan, A.M.4    Goate, A.5    Fox, N.C.6
  • 33
    • 70249127559 scopus 로고    scopus 로고
    • Tau-focused immunotherapy for Alzheimer's disease and related tauopathies
    • Sigurdsson EM. Tau-focused immunotherapy for Alzheimer's disease and related tauopathies. Curr Alzheimer Res. 2009;6:446-50.
    • (2009) Curr Alzheimer Res. , vol.6 , pp. 446-450
    • Sigurdsson, E.M.1
  • 34
    • 34548146119 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    • Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci. 2007;27:9115-29.
    • (2007) J Neurosci. , vol.27 , pp. 9115-9129
    • Asuni, A.A.1    Boutajangout, A.2    Quartermain, D.3    Sigurdsson, E.M.4
  • 35
    • 0022486717 scopus 로고
    • Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
    • Hefti F. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J Neurosci. 1986;6:2155-62.
    • (1986) J Neurosci. , vol.6 , pp. 2155-2162
    • Hefti, F.1
  • 38
    • 84902173668 scopus 로고    scopus 로고
    • Clinical trial of an inhibitor of RAGE-beta-amyloid interactions in Alzheimer disease
    • Galasko D, Bell J, Mancuso JY, Kupiec JW, Sabbagh MN, van Dyck C, et al. Clinical trial of an inhibitor of RAGE-beta-amyloid interactions in Alzheimer disease. Neurology. 2014;82:1536-42.
    • (2014) Neurology. , vol.82 , pp. 1536-1542
    • Galasko, D.1    Bell, J.2    Mancuso, J.Y.3    Kupiec, J.W.4    Sabbagh, M.N.5    Dyck, C.6
  • 40
    • 84855964150 scopus 로고    scopus 로고
    • EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors
    • Prickaerts J, van Goethem NP, Chesworth R, Shapiro G, Boess FG, Methfessel C, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012;62:1099-110.
    • (2012) Neuropharmacology. , vol.62 , pp. 1099-1110
    • Prickaerts, J.1    Goethem, N.P.2    Chesworth, R.3    Shapiro, G.4    Boess, F.G.5    Methfessel, C.6
  • 41
    • 80155167222 scopus 로고    scopus 로고
    • Rosiglitazone and pioglitazone for the treatment of Alzheimer's disease
    • Miller BW, Willett KC, Desilets AR. Rosiglitazone and pioglitazone for the treatment of Alzheimer's disease. Ann Pharmacother. 2011;45:1416-24.
    • (2011) Ann Pharmacother. , vol.45 , pp. 1416-1424
    • Miller, B.W.1    Willett, K.C.2    Desilets, A.R.3
  • 42
    • 0027447602 scopus 로고
    • The protein tyrosine kinase, Fyn, in Alzheimer's disease pathology
    • Shirazi SK, Wood JG. The protein tyrosine kinase, Fyn, in Alzheimer's disease pathology. Neuroreport. 1993;4:435-7.
    • (1993) Neuroreport. , vol.4 , pp. 435-437
    • Shirazi, S.K.1    Wood, J.G.2
  • 43
    • 2442711560 scopus 로고    scopus 로고
    • Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice
    • Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci. 2004;24:4692-7.
    • (2004) J Neurosci. , vol.24 , pp. 4692-4697
    • Chin, J.1    Palop, J.J.2    Yu, G.Q.3    Kojima, N.4    Masliah, E.5    Mucke, L.6


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