Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 mediate the cellular localization of nucleophosmin and its aml-associated mutants

ACS Chemical Biology

Volumn 10, Issue 3, 2015, Pages 855-863

  Mukherjee, Herschel ^a   Chan, Kok Ping ^a   Andresen, Vibeke ^b   Hanley, Mariah L ^a   Gjertsen, Bjørn Tore ^b,c   Myers, Andrew G ^a  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF BERGEN   (Norway)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; AVRAINVILLAMIDE; CYSTEINE; EXPORTIN 1; MUTANT PROTEIN; NATURAL PRODUCT; NUCLEOPHOSMIN; PHOSPHOPROTEIN PHOSPHATASE 1; THREONINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; CELL RECEPTOR; EXPORTIN 1 PROTEIN; INDOLE DERIVATIVE; KARYOPHERIN; NUCLEAR PROTEIN; PROTEIN BINDING;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CENTROSOME; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MASS SPECTROMETRY; NUCLEOLUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; WILD TYPE; ACTIVE TRANSPORT; BINDING SITE; CHEMISTRY; CYTOPLASM; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; METABOLISM; MUTATION; SIGNAL TRANSDUCTION;

EUKARYOTA;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; BINDING SITES; BIOLOGICAL PRODUCTS; CELL NUCLEOLUS; CYTOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; INDOLES; KARYOPHERINS; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN PHOSPHATASE 1; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

EID: 84925356890     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500872g     Document Type: Article

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