Lung cancer cell line screen links fanconi anemia/BRCA pathway defects to increased relative biological effectiveness of proton radiation

International Journal of Radiation Oncology Biology Physics

Volumn 91, Issue 5, 2015, Pages 1081-1089

  Liu, Qi ^a   Ghosh, Priyanjali ^a   Magpayo, Nicole ^a   Testa, Mauro ^b   Tang, Shikui ^b   Gheorghiu, Liliana ^a   Biggs, Peter ^b   Paganetti, Harald ^b   Efstathiou, Jason A ^a   Lu, Hsiao Ming ^b   Held, Kathryn D ^a   Willers, Henning ^a  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURE; DEFECTS; DISEASES; DNA; ENERGY TRANSFER; GAMMA RAYS; PROTON IRRADIATION; RADIOTHERAPY; REPAIR; X RAYS;

CELLULAR RADIOSENSITIVITY; CLINICAL PROTON BEAMS; CLONOGENIC SURVIVAL; DNA DAMAGE RESPONSE; LINEAR ENERGY TRANSFER; METHODS AND MATERIALS; RELATIVE BIOLOGICAL EFFECTIVENESS; SPREAD OUT BRAGG PEAKS;

CELLS;

BRCA1 PROTEIN; BRCA2 PROTEIN; CESIUM 137; COBALT 60; FANCONI ANEMIA GROUP D2 PROTEIN; FANCONI ANEMIA PROTEIN; RAD51 PROTEIN; COBALT;

ARTICLE; CELL CLONE; CELL SCREENING; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; ENERGY TRANSFER; GAMMA RADIATION; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; LUNG CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTON RADIATION; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY; RELATIVE BIOLOGIC EFFECTIVENESS; RNA INTERFERENCE; X IRRADIATION; X RAY; CARCINOMA, NON-SMALL-CELL LUNG; FANCONI ANEMIA; GENETICS; LINEAR ENERGY TRANSFER; LUNG NEOPLASMS; METABOLISM; PROTON THERAPY; REFERENCE VALUE; TUMOR CELL LINE;

BRCA1 PROTEIN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; COBALT RADIOISOTOPES; DNA REPAIR; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; HUMANS; LINEAR ENERGY TRANSFER; LUNG NEOPLASMS; PROTON THERAPY; RAD51 RECOMBINASE; RADIATION TOLERANCE; REFERENCE VALUES; RELATIVE BIOLOGICAL EFFECTIVENESS;

EID: 84925342960     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2014.12.046     Document Type: Article

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