메뉴 건너뛰기




Volumn 66, Issue 2, 2015, Pages 234-243

Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma

Author keywords

Amino acid transporter; ASCT2; Pancreatic cancer; Prognostic factor

Indexed keywords

AMINO ACID TRANSPORTER; ASC AMINO ACID TRANSPORTER 2; CD34 ANTIGEN; KI 67 ANTIGEN; L TYPE AMINO ACID TRANSPORTER 1; LAT1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; SLC1A5 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84925332053     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/his.12464     Document Type: Article
Times cited : (38)

References (38)
  • 1
    • 0025095302 scopus 로고
    • Role of amino acid transport and countertransport in nutrition and metabolism
    • Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev. 1990; 70; 43-77.
    • (1990) Physiol. Rev , vol.70 , pp. 43-77
    • Christensen, H.N.1
  • 2
    • 0029744420 scopus 로고    scopus 로고
    • Cloning of the sodiumdependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line
    • Kekuda R, Prasad PD, Fei YJ et al. Cloning of the sodiumdependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. J. Biol. Chem. 1996; 271; 18657-18661.
    • (1996) J. Biol. Chem , vol.271 , pp. 18657-18661
    • Kekuda, R.1    Prasad, P.D.2    Fei, Y.J.3
  • 3
    • 34547135698 scopus 로고    scopus 로고
    • ASCT2 silencing regulates mammalian target of rapamycin growth and survival signaling in human hepatoma cells
    • Fuch BC, Finger RE, Onan MC et al. ASCT2 silencing regulates mammalian target of rapamycin growth and survival signaling in human hepatoma cells. Am. J. Physiol. Cell Physiol. 2007; 293; C55-C63.
    • (2007) Am. J. Physiol. Cell Physiol , vol.293 , pp. C55-C63
    • Fuch, B.C.1    Finger, R.E.2    Onan, M.C.3
  • 4
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
    • Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin. Cancer Biol. 2006; 15; 254-266.
    • (2006) Semin. Cancer Biol , vol.15 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 5
    • 79955775731 scopus 로고    scopus 로고
    • Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer
    • Okudaira H, Hirano N, Nishii R et al. Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer. J. Nucl. Med. 2011; 52; 822-829.
    • (2011) J. Nucl. Med , vol.52 , pp. 822-829
    • Okudaira, H.1    Hirano, N.2    Nishii, R.3
  • 6
    • 79960140546 scopus 로고    scopus 로고
    • Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy
    • Nakanishi T, Tamai I. Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy. J. Pharm. Sci. 2011; 100; 3731-3750.
    • (2011) J. Pharm. Sci , vol.100 , pp. 3731-3750
    • Nakanishi, T.1    Tamai, I.2
  • 7
    • 0042529207 scopus 로고    scopus 로고
    • Expression of neutral amino acid transporter ASCT2 in human prostate
    • Li R, Younes M, Frolov A et al. Expression of neutral amino acid transporter ASCT2 in human prostate. Anticancer Res. 2003; 23; 3413-3418.
    • (2003) Anticancer Res , vol.23 , pp. 3413-3418
    • Li, R.1    Younes, M.2    Frolov, A.3
  • 8
    • 0036765406 scopus 로고    scopus 로고
    • Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma
    • Whitte D, Ali N, Carlson N et al. Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma. Anticancer Res. 2002; 22; 2555-2557.
    • (2002) Anticancer Res , vol.22 , pp. 2555-2557
    • Whitte, D.1    Ali, N.2    Carlson, N.3
  • 9
    • 57749111596 scopus 로고    scopus 로고
    • Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
    • Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol. Ther. 2009; 121; 29-40.
    • (2009) Pharmacol. Ther , vol.121 , pp. 29-40
    • Ganapathy, V.1    Thangaraju, M.2    Prasad, P.D.3
  • 10
    • 84866926512 scopus 로고    scopus 로고
    • Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC-transporter using positron emission tomography in patients with non-small cell lung or breast cancer
    • Baek S, Choi CM, Ahn SH et al. Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC-transporter using positron emission tomography in patients with non-small cell lung or breast cancer. Clin. Cancer Res. 2012; 18; 5427-5437.
    • (2012) Clin. Cancer Res , vol.18 , pp. 5427-5437
    • Baek, S.1    Choi, C.M.2    Ahn, S.H.3
  • 11
    • 0032508585 scopus 로고    scopus 로고
    • Expression, cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
    • Kanai Y, Segawa H, Miyamoto K et al. Expression, cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 1998; 273; 23629-23632.
    • (1998) J. Biol. Chem , vol.273 , pp. 23629-23632
    • Kanai, Y.1    Segawa, H.2    Miyamoto, K.3
  • 12
    • 4243389920 scopus 로고    scopus 로고
    • Human L-type amino acid transporter 1 (LAT 1): characterization of function and expression in tumor cell lines
    • Yanagida O, Kanai Y, Chairoungdua A et al. Human L-type amino acid transporter 1 (LAT 1): characterization of function and expression in tumor cell lines. Biochim. Biophys. Acta 2001; 1514; 291-302.
    • (2001) Biochim. Biophys. Acta , vol.1514 , pp. 291-302
    • Yanagida, O.1    Kanai, Y.2    Chairoungdua, A.3
  • 13
    • 20044374008 scopus 로고    scopus 로고
    • Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma
    • Kobayashi H, Ishii Y, Takayama T. Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma. J. Surg. Oncol. 2005; 90; 233-238.
    • (2005) J. Surg. Oncol , vol.90 , pp. 233-238
    • Kobayashi, H.1    Ishii, Y.2    Takayama, T.3
  • 14
    • 39449101130 scopus 로고    scopus 로고
    • Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer
    • Kaira K, Oriuchi N, Imai H et al. Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer. Br. J. Cancer 2008; 98; 742-748.
    • (2008) Br. J. Cancer , vol.98 , pp. 742-748
    • Kaira, K.1    Oriuchi, N.2    Imai, H.3
  • 15
    • 34548314415 scopus 로고    scopus 로고
    • Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract
    • Nakanishi K, Ogata S, Matsuo H et al. Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract. Virchows Arch. 2007; 451; 681-690.
    • (2007) Virchows Arch , vol.451 , pp. 681-690
    • Nakanishi, K.1    Ogata, S.2    Matsuo, H.3
  • 16
    • 33646540633 scopus 로고    scopus 로고
    • L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors
    • Nawashiro H, Otani N, Shinomiya N et al. L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Int. J. Cancer 2006; 119; 484-492.
    • (2006) Int. J. Cancer , vol.119 , pp. 484-492
    • Nawashiro, H.1    Otani, N.2    Shinomiya, N.3
  • 17
    • 57649185073 scopus 로고    scopus 로고
    • L-type amino acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
    • Sakata T, Ferdous G, Tsuruta T et al. L-type amino acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol. Int. 2009; 59; 7-18.
    • (2009) Pathol. Int , vol.59 , pp. 7-18
    • Sakata, T.1    Ferdous, G.2    Tsuruta, T.3
  • 18
    • 79955017462 scopus 로고    scopus 로고
    • High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions
    • Ichinoe M, Mikami T, Yoshida T et al. High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions. Pathol. Int. 2011; 61; 281-289.
    • (2011) Pathol. Int , vol.61 , pp. 281-289
    • Ichinoe, M.1    Mikami, T.2    Yoshida, T.3
  • 19
    • 84856492407 scopus 로고    scopus 로고
    • Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis
    • Furuya M, Horiguchi J, Nakajima H et al. Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis. Cancer Sci. 2012; 103; 382- 389.
    • (2012) Cancer Sci , vol.103 , pp. 382- 389
    • Furuya, M.1    Horiguchi, J.2    Nakajima, H.3
  • 20
    • 80054751326 scopus 로고    scopus 로고
    • LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer
    • Kaira K, Oriuchi N, Takahashi T et al. LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer. Am. J. Transl. Res. 2011; 3; 468- 478.
    • (2011) Am. J. Transl. Res , vol.3 , pp. 468- 478
    • Kaira, K.1    Oriuchi, N.2    Takahashi, T.3
  • 21
    • 84864879465 scopus 로고    scopus 로고
    • Prognostic significance of L-type amino acid transporter 1 expression in surgically resected pancreatic cancer
    • Kaira K, Sunose Y, Arakawa K et al. Prognostic significance of L-type amino acid transporter 1 expression in surgically resected pancreatic cancer. Br. J. Cancer 2012; 107; 632-638.
    • (2012) Br. J. Cancer , vol.107 , pp. 632-638
    • Kaira, K.1    Sunose, Y.2    Arakawa, K.3
  • 23
    • 0006651935 scopus 로고
    • Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2
    • Altman A, Cardenas JM, Houghten RA et al. Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. Proc. Natl Acad. Sci. USA 1984; 81; 2176-2180.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 2176-2180
    • Altman, A.1    Cardenas, J.M.2    Houghten, R.A.3
  • 24
    • 0035966056 scopus 로고    scopus 로고
    • Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain
    • Chairoungdua A, Kanai Y, Matsuo H et al. Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. J. Biol. Chem. 2001; 276; 49390- 49399.
    • (2001) J. Biol. Chem , vol.276 , pp. 49390- 49399
    • Chairoungdua, A.1    Kanai, Y.2    Matsuo, H.3
  • 25
    • 84865442587 scopus 로고    scopus 로고
    • Lglutamate enhances methylmercury toxicity by synergistically increasing oxidative stress
    • Khunweeraphong N, Nagamori S, Wiriyasermkul P et al. Lglutamate enhances methylmercury toxicity by synergistically increasing oxidative stress. J. Pharmacol. Sci. 2012; 119; 368- 380.
    • (2012) J. Pharmacol. Sci , vol.119 , pp. 368- 380
    • Khunweeraphong, N.1    Nagamori, S.2    Wiriyasermkul, P.3
  • 26
    • 84901823650 scopus 로고    scopus 로고
    • ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer
    • Shimizu K, Kaira K, Tomizawa Y et al. ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer. Br. J. Cancer 2014; 110; 2030-2039.
    • (2014) Br. J. Cancer , vol.110 , pp. 2030-2039
    • Shimizu, K.1    Kaira, K.2    Tomizawa, Y.3
  • 27
    • 84867742110 scopus 로고    scopus 로고
    • Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity
    • Oppedisano F, Catto M, Koutentis PA et al. Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity. Toxicol. Appl. Pharmacol. 2012; 93; 93-102.
    • (2012) Toxicol. Appl. Pharmacol , vol.93 , pp. 93-102
    • Oppedisano, F.1    Catto, M.2    Koutentis, P.A.3
  • 28
    • 77954482037 scopus 로고    scopus 로고
    • Inhibition of L-type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells
    • Kim CS, Moon IS, Park JH et al. Inhibition of L-type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells. Biol. Pharm. Bull. 2010; 33; 1117-1121.
    • (2010) Biol. Pharm. Bull , vol.33 , pp. 1117-1121
    • Kim, C.S.1    Moon, I.S.2    Park, J.H.3
  • 29
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: a new therapeutic target in cancer
    • Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci. 2010; 35; 427- 433.
    • (2010) Trends Biochem. Sci , vol.35 , pp. 427- 433
    • Wise, D.R.1    Thompson, C.B.2
  • 30
    • 84875894714 scopus 로고    scopus 로고
    • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    • Son J, Lyssiotis CA, Ying H et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 2013; 496; 101-105.
    • (2013) Nature , vol.496 , pp. 101-105
    • Son, J.1    Lyssiotis, C.A.2    Ying, H.3
  • 31
    • 84873363313 scopus 로고    scopus 로고
    • SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival
    • Hassanein M, Hoeksema MD, Shiota M et al. SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin. Cancer Res. 2013; 19; 560-570.
    • (2013) Clin. Cancer Res , vol.19 , pp. 560-570
    • Hassanein, M.1    Hoeksema, M.D.2    Shiota, M.3
  • 32
    • 84902550841 scopus 로고    scopus 로고
    • Targeting glutamine transport to suppress melanoma cell growth
    • Sep 1
    • Wang Q, Beaumont KA, Otte NJ et al. Targeting glutamine transport to suppress melanoma cell growth. Int. J. Cancer 2014; Sep 1; 135(5); 1060-71.
    • (2014) Int. J. Cancer , vol.135 , Issue.5 , pp. 1060-1071
    • Wang, Q.1    Beaumont, K.A.2    Otte, N.J.3
  • 33
    • 84888271341 scopus 로고    scopus 로고
    • Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
    • Willems L, Jacque N, Jacquel A et al. Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Blood 2013; 122; 3521-3532.
    • (2013) Blood , vol.122 , pp. 3521-3532
    • Willems, L.1    Jacque, N.2    Jacquel, A.3
  • 34
    • 84855987831 scopus 로고    scopus 로고
    • Reductive carboxylation supports growth in tumour cells with defective mitochondria
    • Mullen AR, Wheaton WW, Jin ES et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012; 481; 385-388.
    • (2012) Nature , vol.481 , pp. 385-388
    • Mullen, A.R.1    Wheaton, W.W.2    Jin, E.S.3
  • 35
    • 84881329062 scopus 로고    scopus 로고
    • Reductive glutamine metabolism is a function of the a-ketoglutarate to citrate ratio in cells
    • Fendt SM, Bell EL, Keibler MA et al. Reductive glutamine metabolism is a function of the a-ketoglutarate to citrate ratio in cells. Nat. Commun. 2013; 4; 2236.
    • (2013) Nat. Commun , vol.4 , pp. 2236
    • Fendt, S.M.1    Bell, E.L.2    Keibler, M.A.3
  • 36
    • 84857386481 scopus 로고    scopus 로고
    • Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) ligands with novel serine analogs
    • Albers T, Marsiglia W, Thomas T et al. Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) ligands with novel serine analogs. Mol. Pharmacol. 2012; 81; 356-365.
    • (2012) Mol. Pharmacol , vol.81 , pp. 356-365
    • Albers, T.1    Marsiglia, W.2    Thomas, T.3
  • 37
    • 77954757238 scopus 로고    scopus 로고
    • Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with proliferative aminopeptidase inhibitors
    • Fan X, Ross DD, Arakawa H et al. Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with proliferative aminopeptidase inhibitors. Biochem. Pharmacol. 2010; 80; 811-818.
    • (2010) Biochem. Pharmacol , vol.80 , pp. 811-818
    • Fan, X.1    Ross, D.D.2    Arakawa, H.3
  • 38
    • 78751476207 scopus 로고    scopus 로고
    • Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer
    • Imai H, Kaira K, Oriuchi N et al. Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. Anticancer Res. 2010; 30; 4819-4828.
    • (2010) Anticancer Res , vol.30 , pp. 4819-4828
    • Imai, H.1    Kaira, K.2    Oriuchi, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.