-
1
-
-
0025095302
-
Role of amino acid transport and countertransport in nutrition and metabolism
-
Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev. 1990; 70; 43-77.
-
(1990)
Physiol. Rev
, vol.70
, pp. 43-77
-
-
Christensen, H.N.1
-
2
-
-
0029744420
-
Cloning of the sodiumdependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line
-
Kekuda R, Prasad PD, Fei YJ et al. Cloning of the sodiumdependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. J. Biol. Chem. 1996; 271; 18657-18661.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 18657-18661
-
-
Kekuda, R.1
Prasad, P.D.2
Fei, Y.J.3
-
3
-
-
34547135698
-
ASCT2 silencing regulates mammalian target of rapamycin growth and survival signaling in human hepatoma cells
-
Fuch BC, Finger RE, Onan MC et al. ASCT2 silencing regulates mammalian target of rapamycin growth and survival signaling in human hepatoma cells. Am. J. Physiol. Cell Physiol. 2007; 293; C55-C63.
-
(2007)
Am. J. Physiol. Cell Physiol
, vol.293
, pp. C55-C63
-
-
Fuch, B.C.1
Finger, R.E.2
Onan, M.C.3
-
4
-
-
23044474905
-
Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
-
Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin. Cancer Biol. 2006; 15; 254-266.
-
(2006)
Semin. Cancer Biol
, vol.15
, pp. 254-266
-
-
Fuchs, B.C.1
Bode, B.P.2
-
5
-
-
79955775731
-
Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer
-
Okudaira H, Hirano N, Nishii R et al. Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer. J. Nucl. Med. 2011; 52; 822-829.
-
(2011)
J. Nucl. Med
, vol.52
, pp. 822-829
-
-
Okudaira, H.1
Hirano, N.2
Nishii, R.3
-
6
-
-
79960140546
-
Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy
-
Nakanishi T, Tamai I. Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy. J. Pharm. Sci. 2011; 100; 3731-3750.
-
(2011)
J. Pharm. Sci
, vol.100
, pp. 3731-3750
-
-
Nakanishi, T.1
Tamai, I.2
-
7
-
-
0042529207
-
Expression of neutral amino acid transporter ASCT2 in human prostate
-
Li R, Younes M, Frolov A et al. Expression of neutral amino acid transporter ASCT2 in human prostate. Anticancer Res. 2003; 23; 3413-3418.
-
(2003)
Anticancer Res
, vol.23
, pp. 3413-3418
-
-
Li, R.1
Younes, M.2
Frolov, A.3
-
8
-
-
0036765406
-
Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma
-
Whitte D, Ali N, Carlson N et al. Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma. Anticancer Res. 2002; 22; 2555-2557.
-
(2002)
Anticancer Res
, vol.22
, pp. 2555-2557
-
-
Whitte, D.1
Ali, N.2
Carlson, N.3
-
9
-
-
57749111596
-
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
-
Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol. Ther. 2009; 121; 29-40.
-
(2009)
Pharmacol. Ther
, vol.121
, pp. 29-40
-
-
Ganapathy, V.1
Thangaraju, M.2
Prasad, P.D.3
-
10
-
-
84866926512
-
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC-transporter using positron emission tomography in patients with non-small cell lung or breast cancer
-
Baek S, Choi CM, Ahn SH et al. Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC-transporter using positron emission tomography in patients with non-small cell lung or breast cancer. Clin. Cancer Res. 2012; 18; 5427-5437.
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 5427-5437
-
-
Baek, S.1
Choi, C.M.2
Ahn, S.H.3
-
11
-
-
0032508585
-
Expression, cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
-
Kanai Y, Segawa H, Miyamoto K et al. Expression, cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem. 1998; 273; 23629-23632.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 23629-23632
-
-
Kanai, Y.1
Segawa, H.2
Miyamoto, K.3
-
12
-
-
4243389920
-
Human L-type amino acid transporter 1 (LAT 1): characterization of function and expression in tumor cell lines
-
Yanagida O, Kanai Y, Chairoungdua A et al. Human L-type amino acid transporter 1 (LAT 1): characterization of function and expression in tumor cell lines. Biochim. Biophys. Acta 2001; 1514; 291-302.
-
(2001)
Biochim. Biophys. Acta
, vol.1514
, pp. 291-302
-
-
Yanagida, O.1
Kanai, Y.2
Chairoungdua, A.3
-
13
-
-
20044374008
-
Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma
-
Kobayashi H, Ishii Y, Takayama T. Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma. J. Surg. Oncol. 2005; 90; 233-238.
-
(2005)
J. Surg. Oncol
, vol.90
, pp. 233-238
-
-
Kobayashi, H.1
Ishii, Y.2
Takayama, T.3
-
14
-
-
39449101130
-
Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer
-
Kaira K, Oriuchi N, Imai H et al. Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer. Br. J. Cancer 2008; 98; 742-748.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 742-748
-
-
Kaira, K.1
Oriuchi, N.2
Imai, H.3
-
15
-
-
34548314415
-
Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract
-
Nakanishi K, Ogata S, Matsuo H et al. Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract. Virchows Arch. 2007; 451; 681-690.
-
(2007)
Virchows Arch
, vol.451
, pp. 681-690
-
-
Nakanishi, K.1
Ogata, S.2
Matsuo, H.3
-
16
-
-
33646540633
-
L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors
-
Nawashiro H, Otani N, Shinomiya N et al. L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors. Int. J. Cancer 2006; 119; 484-492.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 484-492
-
-
Nawashiro, H.1
Otani, N.2
Shinomiya, N.3
-
17
-
-
57649185073
-
L-type amino acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer
-
Sakata T, Ferdous G, Tsuruta T et al. L-type amino acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer. Pathol. Int. 2009; 59; 7-18.
-
(2009)
Pathol. Int
, vol.59
, pp. 7-18
-
-
Sakata, T.1
Ferdous, G.2
Tsuruta, T.3
-
18
-
-
79955017462
-
High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions
-
Ichinoe M, Mikami T, Yoshida T et al. High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: comparison with non-cancerous lesions. Pathol. Int. 2011; 61; 281-289.
-
(2011)
Pathol. Int
, vol.61
, pp. 281-289
-
-
Ichinoe, M.1
Mikami, T.2
Yoshida, T.3
-
19
-
-
84856492407
-
Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis
-
Furuya M, Horiguchi J, Nakajima H et al. Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis. Cancer Sci. 2012; 103; 382- 389.
-
(2012)
Cancer Sci
, vol.103
, pp. 382- 389
-
-
Furuya, M.1
Horiguchi, J.2
Nakajima, H.3
-
20
-
-
80054751326
-
LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer
-
Kaira K, Oriuchi N, Takahashi T et al. LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer. Am. J. Transl. Res. 2011; 3; 468- 478.
-
(2011)
Am. J. Transl. Res
, vol.3
, pp. 468- 478
-
-
Kaira, K.1
Oriuchi, N.2
Takahashi, T.3
-
21
-
-
84864879465
-
Prognostic significance of L-type amino acid transporter 1 expression in surgically resected pancreatic cancer
-
Kaira K, Sunose Y, Arakawa K et al. Prognostic significance of L-type amino acid transporter 1 expression in surgically resected pancreatic cancer. Br. J. Cancer 2012; 107; 632-638.
-
(2012)
Br. J. Cancer
, vol.107
, pp. 632-638
-
-
Kaira, K.1
Sunose, Y.2
Arakawa, K.3
-
23
-
-
0006651935
-
Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2
-
Altman A, Cardenas JM, Houghten RA et al. Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. Proc. Natl Acad. Sci. USA 1984; 81; 2176-2180.
-
(1984)
Proc. Natl Acad. Sci. USA
, vol.81
, pp. 2176-2180
-
-
Altman, A.1
Cardenas, J.M.2
Houghten, R.A.3
-
24
-
-
0035966056
-
Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain
-
Chairoungdua A, Kanai Y, Matsuo H et al. Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. J. Biol. Chem. 2001; 276; 49390- 49399.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 49390- 49399
-
-
Chairoungdua, A.1
Kanai, Y.2
Matsuo, H.3
-
25
-
-
84865442587
-
Lglutamate enhances methylmercury toxicity by synergistically increasing oxidative stress
-
Khunweeraphong N, Nagamori S, Wiriyasermkul P et al. Lglutamate enhances methylmercury toxicity by synergistically increasing oxidative stress. J. Pharmacol. Sci. 2012; 119; 368- 380.
-
(2012)
J. Pharmacol. Sci
, vol.119
, pp. 368- 380
-
-
Khunweeraphong, N.1
Nagamori, S.2
Wiriyasermkul, P.3
-
26
-
-
84901823650
-
ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer
-
Shimizu K, Kaira K, Tomizawa Y et al. ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer. Br. J. Cancer 2014; 110; 2030-2039.
-
(2014)
Br. J. Cancer
, vol.110
, pp. 2030-2039
-
-
Shimizu, K.1
Kaira, K.2
Tomizawa, Y.3
-
27
-
-
84867742110
-
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity
-
Oppedisano F, Catto M, Koutentis PA et al. Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity. Toxicol. Appl. Pharmacol. 2012; 93; 93-102.
-
(2012)
Toxicol. Appl. Pharmacol
, vol.93
, pp. 93-102
-
-
Oppedisano, F.1
Catto, M.2
Koutentis, P.A.3
-
28
-
-
77954482037
-
Inhibition of L-type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells
-
Kim CS, Moon IS, Park JH et al. Inhibition of L-type amino acid transporter modulates the expression of cell cycle regulatory factors in KB oral cancer cells. Biol. Pharm. Bull. 2010; 33; 1117-1121.
-
(2010)
Biol. Pharm. Bull
, vol.33
, pp. 1117-1121
-
-
Kim, C.S.1
Moon, I.S.2
Park, J.H.3
-
29
-
-
77955281020
-
Glutamine addiction: a new therapeutic target in cancer
-
Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci. 2010; 35; 427- 433.
-
(2010)
Trends Biochem. Sci
, vol.35
, pp. 427- 433
-
-
Wise, D.R.1
Thompson, C.B.2
-
30
-
-
84875894714
-
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
-
Son J, Lyssiotis CA, Ying H et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 2013; 496; 101-105.
-
(2013)
Nature
, vol.496
, pp. 101-105
-
-
Son, J.1
Lyssiotis, C.A.2
Ying, H.3
-
31
-
-
84873363313
-
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival
-
Hassanein M, Hoeksema MD, Shiota M et al. SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin. Cancer Res. 2013; 19; 560-570.
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 560-570
-
-
Hassanein, M.1
Hoeksema, M.D.2
Shiota, M.3
-
32
-
-
84902550841
-
Targeting glutamine transport to suppress melanoma cell growth
-
Sep 1
-
Wang Q, Beaumont KA, Otte NJ et al. Targeting glutamine transport to suppress melanoma cell growth. Int. J. Cancer 2014; Sep 1; 135(5); 1060-71.
-
(2014)
Int. J. Cancer
, vol.135
, Issue.5
, pp. 1060-1071
-
-
Wang, Q.1
Beaumont, K.A.2
Otte, N.J.3
-
33
-
-
84888271341
-
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
-
Willems L, Jacque N, Jacquel A et al. Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Blood 2013; 122; 3521-3532.
-
(2013)
Blood
, vol.122
, pp. 3521-3532
-
-
Willems, L.1
Jacque, N.2
Jacquel, A.3
-
34
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012; 481; 385-388.
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
-
35
-
-
84881329062
-
Reductive glutamine metabolism is a function of the a-ketoglutarate to citrate ratio in cells
-
Fendt SM, Bell EL, Keibler MA et al. Reductive glutamine metabolism is a function of the a-ketoglutarate to citrate ratio in cells. Nat. Commun. 2013; 4; 2236.
-
(2013)
Nat. Commun
, vol.4
, pp. 2236
-
-
Fendt, S.M.1
Bell, E.L.2
Keibler, M.A.3
-
36
-
-
84857386481
-
Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) ligands with novel serine analogs
-
Albers T, Marsiglia W, Thomas T et al. Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) ligands with novel serine analogs. Mol. Pharmacol. 2012; 81; 356-365.
-
(2012)
Mol. Pharmacol
, vol.81
, pp. 356-365
-
-
Albers, T.1
Marsiglia, W.2
Thomas, T.3
-
37
-
-
77954757238
-
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with proliferative aminopeptidase inhibitors
-
Fan X, Ross DD, Arakawa H et al. Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with proliferative aminopeptidase inhibitors. Biochem. Pharmacol. 2010; 80; 811-818.
-
(2010)
Biochem. Pharmacol
, vol.80
, pp. 811-818
-
-
Fan, X.1
Ross, D.D.2
Arakawa, H.3
-
38
-
-
78751476207
-
Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer
-
Imai H, Kaira K, Oriuchi N et al. Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. Anticancer Res. 2010; 30; 4819-4828.
-
(2010)
Anticancer Res
, vol.30
, pp. 4819-4828
-
-
Imai, H.1
Kaira, K.2
Oriuchi, N.3
|