Hyperglycemia impairs cytotrophoblast function via stress signaling

American Journal of Obstetrics and Gynecology

Volumn 211, Issue 5, 2014, Pages 541.e1-541.e8

  R Cawyer, Chase ^a   Horvat, Darijana ^a   Leonard, Dean ^b   Allen, Steven R ^a   Jones, Richard O ^a   Zawieja, David C ^a   Kuehl, Thomas J ^a   Uddin, Mohammad N ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b BAYLOR UNIVERSITY   (United States)

Author keywords

angiogenesis; cell invasion; cytotrophoblast cells; hyperglycemia

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GLUCOSE; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACENTAL GROWTH FACTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; ROSIGLITAZONE; UROKINASE; VASCULOTROPIN; VASCULOTROPIN 165; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CELL SURFACE RECEPTOR; ENG PROTEIN, HUMAN; FLT1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; LEUKOCYTE ANTIGEN; PLACENTA PROTEIN; PYRIDINE DERIVATIVE; SERPINE1 PROTEIN, HUMAN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VEGFA PROTEIN, HUMAN;

CELL LYSATE; CELL STRESS; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTROPHOBLAST; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERGLYCEMIA; IMMUNOBLOTTING; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; PHOSPHORYLATION; PREGNANCY; PREGNANCY DIABETES MELLITUS; SIGNAL TRANSDUCTION; TROPHOBLAST;

ANTIGENS, CD; DIABETES, GESTATIONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; IMIDAZOLES; INTERLEUKIN-6; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMERASE CHAIN REACTION; PPAR GAMMA; PREGNANCY; PREGNANCY PROTEINS; PYRIDINES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES; TROPHOBLASTS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84925287096     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2014.04.033     Document Type: Conference Paper

References (47)

1. U.D. Anderson, M.G. Olsson, K.H. Kristensen, B. Åkerström, and S.R. Hansson Review: biochemical markers to predict preeclampsia Placenta 33 Suppl 2012 S42 S47
2. G. Pridjian, and J.B. Puschett Preeclampsia. Part I: clinical and pathophysiological considerations Obstet Gynecol Surv 57 2002 598 618
3. M.N. Uddin, S. Allen, R. Jones, D. Zawieja, and T. Kuehl Pathogenesis of preeclampsia: marinobufagenin and angiogenic imbalance as biomarkers of the syndrome Transl Res 160 2012 99 113
4. Y. Yu, A.J. Jenkins, and A.J. Nankervis Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women Diabetologia 52 2009 160 168
5. M.N. Uddin, M.R. Beeram, and T.J. Kuehl Diabetes mellitus and preeclampsia Med J Obstet Gynecol 1 2013 1016
6. H. Fox The placenta in pregnancy hypertension P.C. Rubin, Handbook of hypertension. Vol. 10: hypertension in pregnancy 1988 Elsevier New York 16 37
7. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy Am J Obstet Gynecol 183 2000 S1 S22
8. Y. Zhou, C.H. Damsky, K. Chiu, J.M. Roberts, and S.J. Fisher Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts J Clin Invest 91 1993 950 960
9. Y. Zhou, S.J. Fisher, and M. Janatpour Human cytotrophoblasts adopt a vascular phenotype as they differentiate: a strategy for successful endovascular invasion? J Clin Invest 99 1997 2139 2151
10. L.K. Harris, R.J. Keogh, and M. Wareing Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism Am J Pathol 169 2006 1863 1874
11. I.A. Brosens, W.B. Robertson, and H.G. Dixon The role of the spiral arteries in the pathogenesis of preeclampsia Obstet Gynecol Annu 1 1972 177 191
12. F.G. Cunningham, J.L. Kenneth, S.L. Bloom, J.C. Hauth, D.J. Rouse, and C.Y. Spong Implantation, embryogenesis, and placental development Williams obstetrics 23rd ed. 2010 McGraw-Hill New York 36 77
13. H.A. Chapman Plasminogen activators, integrins and the coordinated regulation of cell adhesion and migration Cur Opin Cell Biol 9 1997 714 724
14. D.A. Waltz, L.R. Natkin, R.M. Fujita, Y. Wei, and H.A. Chapman Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin J Clin Invest 100 1997 58 67
15. Q. Feng, Y. Liu, and K. Liu Expression of the urokinase, plasminogen activator inhibitors and urokinase receptor in pregnant rhesus monkey uterus during early placentation Placenta 21 2000 184 193
16. P.K. Vayalil, K.E. Iles, J. Choi, A.K. Yi, E.M. Postlethwait, and R.M. Liu Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter Am J Physiol Lung Cell Mol Physiol 293 2007 L1281 L1292
17. L. Chang, and M. Karin Mammalian MAP kinase signaling cascades Nature 410 2001 37 40
18. T.P. Garrington, and G.L. Johnson Organization and regulation of mitogen-activated protein kinase signaling pathways Curr Opin Cell Biol 11 1999 211 218
19. W. Kolch Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions Biochem J 351 2000 289 305
20. J.M. Kyriakis, and J. Avruch Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Physiol Rev 81 2001 807 869
21. A.R. Nebreda, and A. Porras p38 MAP kinases: beyond the stress response Trends Biochem Sci 25 2000 257 260
22. M.N. Uddin, D. Horvat, S.S. Glaser, B.M. Mitchell, and J.B. Puschett Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function J Biol Chem 283 2008 17946 17953
23. T. Hirono Interleukin 6 and its receptor: ten years later Int Rev Immunol 16 1998 24 84
24. A. Zauberman, D. Zipori, M. Krupsky, and R. Ben-Levy Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3 Oncogene 18 1999 388 393
25. Y. Barak, M.C. Nelson, and E.S. Ong PPARgamma is required for placental, cardiac, and adipose tissue development Mol Cell 4 1999 585 595
26. N. Kubota, Y. Terauchi, and H. Miki PPARgamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance Mol Cell 4 1999 597 609
27. K.W. Marvin, and R.L. Eyholt The 15-deoxy-D12.14-prostaglandin J2 receptor, peroxisome proliferator-activated receptor-gamma (PPARgamma) is expressed in human gestational tissues and is functionally active in JEG3 choriocarcinoma cells Placenta 21 2000 436 440
28. W.T. Shaiff, M.G. Carlson, S.D. Smith, R. Levy, D.M. Nelson, and Y. Sadovsky Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner J Clin Endocrinol Metab 85 2000 3874 3881
29. F.P. McCarthy, S. Drewlo, J. Kingdom, E.J. Johns, S.K. Walsh, and L.C. Kenny Peroxisome proliferator-activated receptor-γ as a potential therapeutic target in the treatment of preeclampsia Hypertension 58 2011 280 286
30. A. Terrade, K. Schoonjans, and L. Pavan PPARgamma/RXRalpha heterodimers control human trophoblast invasion J Clin Endocrinol Metab 86 2001 5017 5024
31. L.L. Waite, E.C. Person, Yan Zhou, K.H. Lim, T.S. Scanlan, and R.N. Taylor Placental peroxisome proliferator-activated receptor-gamma is up-regulated by pregnant serum J Clin Endocrinol Metab 85 2000 3808 3814
32. A. Tarrade, K. Schoonjans, L. Pavan, J. Auwerx, C. Rochette-Egly, D. Evain-Brion, and T. Fournier PPARgamma/RXRalpha heterodimers control human trophoblast invasion J Clin Endocrinol Metab 86 2001 5017 5024
33. A. Athanassiades, G.S. Hamilton, and P.K. Lala Vascular endothelial growth factor stimulates proliferation but not migration or invasiveness in human extravillous trophoblast Biol Rep 59 1998 643 654
34. I.P. Crocker, B.K. Strachan, G.E. Lash, S. Cooper, A.Y. Warren, and P.N. Barker Vascular endothelial growth factor but not placental growth factor promotes trophoblast syncytialization in vitro J Soc Gynecol Invest 8 2001 341 346
35. D.S. Torry, M. Hinrichs, and R. Torry Determinants of placental vascularity Am J Reprod Immunol 51 2004 257 268
36. D. Maglione, V. Guerriero, and G. Viglietto Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene on chromosome 14 Oncogene 8 1993 925 931
37. S. Venkatesha, M. Toporsian, and C. Lam Soluble endoglin contributes to the pathogenesis of preeclampsia Nat Med 12 2006 642 649
38. H. Vu, M.R. Ianosi-Irimie, and C. Pridjian The involvement of marinobufagenin in a rat model of human preeclampsia Am J Nephrol 25 2005 520 528
39. E. Agunanne, D. Horvat, and R. Harrison Marinobufagenin levels in preeclamptic patients: a preliminary report Am J Perinatol 28 2011 509 514
40. L. Zhou, H. Xue, and Z. Wang Angiotensin-(1-7) attenuates high glucose-induced proximal tubular epithelial-to-mesenchymal transition via inhibiting ERK1/2 and p38 phosphorylation Life Sci 90 2012 454 462
41. M.N. Uddin, D. Horvat, and S.S. Glaser Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells Placenta 29 2008 266 273
42. N. Suwaki, H. Masuyama, A. Masumoto, N. Takamoto, and Y. Hiramatsu Expression and potential role of peroxisome proliferator-activated receptor g in the placenta of diabetic pregnancy Placenta 28 2007 315 323
43. A. Jawerbaum, E. Capobianco, and C. Pustovrh Influence of peroxisome proliferator-activated receptor γ activation by its endogenous ligand 15-deoxy 12,14 prostaglandin J 2 on nitric oxide production in term placental tissues from diabetic women Mol Hum Reprod 10 2004 671 676
44. S.J. Fisher The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia Reprod Biol Endocrinol 2 2004 53
45. L. Myatt Role of placenta in preeclampsia Endocrine 19 2002 103 111
46. I. Agarwal, and S.A. Karumanchi Preeclampsia and the anti-angiogenic state Pregnancy Hypertens 1 2011 17 21
47. G. Desoye, S.H. Mouzon, and E. Shafrir The placenta in diabetic pregnancy M. Hod, L. Jovanovic, G.C. Di Renzo, A. Leiva, O. Langer, Textbook of diabetes and pregnancy 2003 Martin Dunitz London 126 143