DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

GLIA

Volumn 63, Issue 5, 2015, Pages 812-825

  Cox, Donal J ^a   Field, Robert H ^a   Williams, David G ^a   Baran, Marcin ^a   Bowie, Andrew G ^a   Cunningham, Colm ^a   Dunne, Aisling ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Astrocytes; Microglia; Neurodegeneration; Nucleic acid sensing; Type I interferon

Indexed keywords

BETA INTERFERON; COLONY STIMULATING FACTOR 1; CXCL2 CHEMOKINE; DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERFERON RECEPTOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NUCLEIC ACID; RANTES; ALPHA BETA INTERFERON RECEPTOR; CYTOKINE; IFI16 PROTEIN, MOUSE; NUCLEAR PROTEIN; PHOSPHOPROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE SILENCING; GLIOSIS; IN VITRO STUDY; MICROGLIA; MOLECULAR SENSOR; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ANIMAL; BRAIN; C57BL MOUSE; CELL CULTURE; COMPLICATION; CYTOLOGY; DEFICIENCY; DEGENERATIVE DISEASE; DISEASE MODEL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; NEWBORN; PATHOLOGY; PHYSIOLOGY; TIME;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; GLIOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NEURODEGENERATIVE DISEASES; NUCLEAR PROTEINS; NUCLEIC ACIDS; PHOSPHOPROTEINS; RECEPTOR, INTERFERON ALPHA-BETA; RNA, SMALL INTERFERING; TIME FACTORS; UP-REGULATION;

EID: 84925257470     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22786     Document Type: Article

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