Lecithin/TPGS-based spray-dried self-microemulsifying drug delivery systems: In vitro pulmonary deposition and cytotoxicity

International Journal of Pharmaceutics

Volumn 485, Issue 1-2, 2015, Pages 249-260

  Ishak, Rania A H ^a   Osman, Rihab ^a  

^a African Union Organization St Abbassia   (Egypt)

Author keywords

Atorvastatin; Cytotoxicity; Lecithin; Pulmonary deposition; SMEDDS; Spray drying; TPGS

Indexed keywords

ALCOHOL; ATORVASTATIN; CARBOHYDRATE; DRUG CARRIER; GLYCEROPHOSPHOLIPID; MACROGOL; MYRISTIC ACID ISOPROPYL ESTER; OIL; PHOSPHATIDYLCHOLINE; SUCCINIC ACID; SURFACTANT; TOCOFERSOLAN; AEROSOL; ALPHA TOCOPHEROL; ALPHA-TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; EMULSION; MACROGOL DERIVATIVE; POWDER;

ARTICLE; CELL STRUCTURE; CYTOTOXICITY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER CELL LINE; LUNG FLUID; MICROEMULSION; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; SPRAY DRYING; AEROSOL; ANALOGS AND DERIVATIVES; CELL SURVIVAL; CHEMISTRY; COMPARATIVE STUDY; DESICCATION; DOSE RESPONSE; DRUG EFFECTS; DRUG STABILITY; EMULSION; IC50; INHALATIONAL DRUG ADMINISTRATION; LUNG; LUNG NEOPLASMS; MEDICINAL CHEMISTRY; METABOLISM; PATHOLOGY; PHARMACEUTICS; PROCEDURES; SOLUBILITY; TUMOR CELL LINE;

ADMINISTRATION, INHALATION; AEROSOLS; ATORVASTATIN CALCIUM; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DESICCATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG STABILITY; EMULSIONS; HUMANS; INHIBITORY CONCENTRATION 50; LECITHINS; LUNG; LUNG NEOPLASMS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POWDERS; SOLUBILITY; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; VITAMIN E;

EID: 84925250466     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.03.019     Document Type: Article

References (74)

1. R. Aboofazeli, and M.J. Lawrence Investigations into the formation and characterization of phospholipid microemulsions II. Pseudo-ternary phase diagrams of systems containing water-lecithin-isopropyl myristate and alcohol: influence of purity of lecithin Int. J. Pharm. 106 1994 42
2. F.H.A. Al-Jeboori, T.A.M. Al-Shimiesawi, and O.M.N. Jassim Synthesis and characterization of some essential amino acid metal complexes having biological activity J. Chem. Pharm. Res. 5 2013 172 176
3. D. Attwood, C. Mallona, and C.J. Taylorb Phase studies on oil-in-water phospholipid microemulsions Int. J. Pharm. 84 1992 R5 R8
4. A. Bajaj, M.R. Rao, I. Khole, and G. Munjapara Self-nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate Drug Dev. Ind. Pharm. 39 2013 635 645
5. M. BaroÍn, and A.H. Buep Empirical relation between permittivity and viscosity of polar and non-polar liquids Speculat. Sci. Technol. 20 1997 45 50
6. S. Biswal, J. Sahoo, P.N. Murthy, R.P. Giradkar, and J.G. Avari Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000 AAPS PharmSciTech 9 2008 563 570
7. A. Bumajdad, and J. Eastoe Conductivity of water-in-oil microemulsions stabilizedby mixed surfactants J. Colloid Interface Sci. 274 2004 268 276
8. K. Cerpnjak, A. Zvonar, F. Vrečer, and M. Gašperlin Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen Drug Dev. Ind. Pharm. 13 2014 1 10
9. J. Chen, T. Lan, J. Hou, J. Zhang, Y. An, L. Tie, Y. Pan, J. Liu, and X. Li Atorvastatin sensitizes human non-small cell lung carcinomas to carboplatin via suppression of AKT activation and upregulation of TIMP-1 Int. J. Biochem. Cell Biol. 44 2012 759 769
10. W. Cho, M.S. Kim, J.S. Kim, J. Park, H.J. Park, K.H. Cha, J.S. Park, and S.J. Hwang Optimized formulation of solid self-microemulsifying sirolimus delivery systems Int. J. Nanomed. 8 2013 1673 1682
11. N.B. Colthup, L.H. Daly, and S.E. Wiberley Introduction to Infrared and Raman Spectroscopy 1990 Academic Press New York
12. L. Corcos, and C.L. Jossic-Corcos Statins: perspectives in cancer therapeutics Dig. Liver Dis. 45 2013 795 802
13. J.M. Dintaman, and J.A. Silverman Inhibition of P-glycoprotein by d-tocopheryl polyethylene glycol 1000 succinate (TPGS) Pharm. Res. 16 1999 1550 1556
14. S. Doktorovová, J. Araújo, M.L. Garcia, E. Rakovsky, and E.B. Souto Formulating fluticasone propionate in novel PEG-containing nanostructured lipid carriers (PEG-NLC) Colloid Surf. B 75 2010 538 542
15. X. Dong, C.A. Mattingly, M. Tseng, M. Cho, V.R. Adams, and R.J. Mumper Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization Eur. J. Pharm. Biopharm. 72 2009 9 17
16. M.H.D.K. El-Hallak, M.K. Sarfraz, S. Azarmi, W.H. Roa, W.H. Finlay, and R. Lobenberg Pulmonary delivery of inhalable nanoparticles: dry-powder inhalers Ther. Deliv. 2 2011 1313 1324
17. L.H. Emara, R.M. Badr, and A.A. Elbary Improving the dissolution and bioavailability of nifedipine using solid dispersions and solubilizers Drug Dev. Ind. Pharm. 28 2002 795 807
18. J.-Y. Fang, C.-F. Hung, S.-C. Hua, and T.-L. Hwang Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: drug release and cytotoxicity against cancer cells Ultrasonics 49 2009 39 46
19. H.F. Florindo, S. Pandit, L.M.D. Goncalves, H.O. Alpar, and A.J. Almeida New approach on the development of a mucosal vaccine against strangles: systemic and mucosal immune responses in a mouse model Vaccine 27 2009 1230 1241
20. K.K. Gill, A. Kaddoumi, and S. Nazzal Mixed micelles of PEG2000-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines Eur. J. Pharm. Sci. 46 2012 64 71
21. T.K. Giri, N.G. Goswami, and V.K. Jha Prospective and challenges of micro-emulsion as a novel carrier for drug delivery J. PharmSciTech 2 2013 56 61
22. A.J. Hickey, and H.M. Mansour Delivery of drugs by the pulmonary route A.T. Florence, J. Siepmann, Modern Pharmaceutics 2009 Taylor and Francis New York 191 219
23. C.W. Holtzman, B.S. Wiggins, and S.A. Spinler Role of P-glycoprotein in statin drug interactions Pharmacotherapy 26 2006 1601 1607
24. T.L. Hwang, C.L. Fang, C.H. Chen, and J.Y. Fang Permeation enhancer-containing water-in-oil nanoemulsions as carriers for intravesical cisplatin delivery Pharm. Res. 26 2009 2314 2323
25. K. Imamura, A. Fukushima, K. Sakaura, T. Sugita, T. Sakiyama, and K. Nakanishi WaTer sorption and glass transition behaviors of freeze-dried sucrose-dextran mixtures J. Pharm. Sci. 91 2002 2175 2181
26. M. Isenor, S.G.W. Kaminskyj, R.J. Rodriguez, R.S. Redmance, and K.M. Gough Characterization of mannitol in Curvularia protuberata hyphae by FTIR and Raman spectromicroscopy Analyst 135 2010 3249 3254
27. N. Jain, R. Raghuwanshi, and D. Jain Development and validation of RP-HPLC method for simultaneous estimation of atorvastatin calcium and fenofibrate in tablet dosage forms Indian J. Pharm. Sci. 70 2008 263 265
28. L. Jiang, X. Li, L. Liu, and Q. Zhang Thiolated chitosan-modified PLA-PCL-TPGS nanoparticles for oral chemotherapy of lung cancer Nanoscale Res. Lett. 8 2013 66
29. M.R. Johan, and L.M. Ting Structural thermal and electrical properties of nano manganese-composite polymer electrolytes Int. J. Electrochem. Sci. 6 2001 4737 4748
30. W. Junping, K. Takayama, T. Nagai, and Y. Maitani Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid oleic acid, vitamin E and cholesterol Int. J. Pharm. 251 2003 13 21
31. W.T. Ke, S.Y. Lin, H.O. Ho, and M.T. Sheu Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate (TPGS) as a surfactant for the oral delivery of protein drugs J. Control Release 102 2005 489 507
32. V. Khurana, H.R. Bejjanki, G. Caldito, and M.W. Owens Statins reduce the risk of lung cancer in humans: a large case - control study of US veterans Chest 131 2007 1282 1288
33. P.J. Kuehl, A. Cherringto, D.E. Dobry, D. Edgerton, D.T. Friesen, C. Hobbs, C.L. Leach, B. Murri, D. Neal, D.K. Lyon, D.T. Vodak, and M.D. Reed Biologic comparison of inhaled insulin formulations: exubera(TM) and novel spray-dried engineered particles of dextran-10 AAPS PharmSciTech 15 2014 1545 1550
34. P. Kumar, and K.L. Mittal Handbook of Microemulsion Science and Technology 1999 CRC Press London
35. S. Kumar, R. Gokhale, and D.J. Burgess Sugars as bulking agents to prevent nano-crystal aggregation during spray or freeze-drying Int. J. Pharm. 471 2014 303 311
36. W. Lam, C.H. Leung, H.L. Chan, and W.F. Fong Toxicity and DNA binding of dextran-doxorubicin conjugates in multidrug-resistant KB-V1 cells: optimization of dextran size Anticancer Drugs 11 2000 377 384
37. A. Laouini, V. Andrieu, L. Vecellio, H. Fessi, and C. Charcosset Characterization of different vitamin E carriers intended for pulmonary drug delivery Int. J. Pharm. 471 2014 385 390
38. Y.M. Lin, J.Y. Wu, Y.C. Chen, Y.D. Su, W.T. Ke, H.O. Ho, and M.T. Sheu In situ formation of nanocrystals from a self-microemulsifying drug delivery system to enhance oral bioavailability of fenofibrate Int. J. Nanomed. 6 2011 2445 2457
39. M.J. Lawrence, and G.D. Rees Microemulsion-based media as novel drug delivery systems Adv. Drug Deliv. Rev. 45 2000 89 121
40. G. Lu, H. Xiao, H. You, Y. Lin, H. Jin, B. Snagaski, and C.S. Yang Synergistic inhibition of lung tumorigenesis by a combination of green tea polyphenols and atorvastatin Clin. Cancer Res. 14 2008 4981 4988
41. P. Ma, X. Dong, C.L. Swadley, A. Gupte, M. Leggas, H.C. Ledebur, and R.J. Mumper Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia J. Biomed. Nanotechnol. 5 2009 151 161
42. K. Margulis-Goshen, M. Weitman, D.T. Major, and S. Magdassi Inhibition of crystallization and growth of celecoxib nanoparticles formed from volatile microemulsions J. Pharm. Sci. 100 2011 4390 4400
43. M.R.C. Marques, R. Loebenberg, and M. Almukainzi Simulated biological fluids with possible application in dissolution testing Dissolut. Technol. 18 2011 15 28
44. S.I. McFarlane, R. Muniyappa, R. Francisco, and J.R. Sowers Pleiotropic effects of statins: lipid reduction and beyond J. Clin. Endocrinol. Metab. 87 2002 1451 1458
45. G.M. Mekhail, A.O. Kamel, G.A.S. Awad, and N.D. Mortada Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan Int. J. Biol. Macromol. 51 2012 351 363
46. R. Mitra, I. Pezron, Y. Li, and A.K. Mitra Enhanced pulmonary delivery of insulin by lung lavage fluid and phospholipids Int. J. Pharm. 217 2001 25 31
47. M. Moreno, P. Frutos, and M.P. Ballesteros Lyophilized lecithin based oil-water microemulsions as a new and low toxic delivery system for amphotericin B Pharm. Res. 18 2001 344 351
48. M.A. Moreno, M.P. Ballesteros, and P. Frutos Lecithin-based oil-in-water microemulsions for parenteral use: pseudoternary phase diagrams, characterization and toxicity studies J. Pharm. Sci. 92 2003 1428 1437
49. L. Mu, M.-M. Teo, H.-Z. Ning, C.-S. Tan, and S.-S. Feng Novel powder formulations for controlled delivery of poorly soluble anticancer drug: application and investigation of TPGS and PEG in spray-dried particulate system J. Control Rel. 103 2005 565 575
50. J.M. Munson, and A.C. Shieh Interstitial fluid flow in cancer: implications for disease progression and treatment Cancer Manage. Res. 6 2014 317 328
51. A.R. Najafabadi, K. Gilani, M. Barghi, and M. Rafiee-Tehrani The effect of vehicle on physical properties and aerosolisation behaviour of disodium cromoglycate microparticles spray dried alone or with l-leucine Int. J. Pharm. 285 2004 97 108
52. T. Nakate, H. Yoshida, A. Ohike, Y. Tokunaga, R. Ibuki, and Y. Kawashima Formulation development of inhalation powders for FK888 using the E-haler to improve the inhalation performance at a high dose and its absorption in healthy volunteers Eur. J. Pharm. Biopharm. 59 2005 25 33
53. A.S. Narang, D. Delmarre, and D. Gao Stable drug encapsulation in micelles and microemulsions Int. J. Pharm. 345 2007 9 25
54. S. Natesan, A. Sugumaran, C. Ponnusamy, V. Jeevanesan, G. Girija, and R. Palanichamy Development and evaluation of magnetic microemulsion: tool for targeted delivery of camptothecin to BALB/c mice-bearing breast cancer J. Drug Target. 22 2014 913 926
55. D.H. Oh, J.H. Kang, D.W. Kim, B.J. Lee, J.O. Kim, C.S. Yong, and H.G. Choi Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier Int. J. Pharm. 420 2011 412 418
56. R. Osman, P.L. Kan, G. Awad, N. Mortada, A.-E. EL-Shamy, and O. Alpar Spray dried inhalable ciprofloxacin powder with improved aerosolisation and antimicrobial activity Int. J. Pharm. 449 2013 44 58
57. D. Panghal, M. Nagpal, G.S. Thakur, and S. Arora Dissolution improvement of atorvastatin calcium using modified locust bean gum by the solid dispersion technique Sci. Pharm. 82 2014 177 191
58. D. Paolino, C.A. Ventura, S. Nisticò, G. Puglisi, and M. Fresta Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability Int. J. Pharm. 244 2002 21 31
59. C.-W. Park, X. Li, F.G. Vogt, J.D. Hayes, J.B. Zwischenberger, E.-S. Park, and H.M. Mansour Advanced spray-dried design physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols Int. J. Pharm. 455 2013 374 392
60. J.S. Patil, and S. Sarasija Pulmonary drug delivery strategies: a concise, systematic review Lung India 29 2012 44 49
61. S. Peltola, P. Saarinen-Savolainen, J. Kiesvaara, T.M. Suhonen, and A. Urtti Microemlsions for topical delivery of estradiol Int. J. Pharm. 254 2003 99 107
62. D. Pooja, H. Kulhari, M.K. Singh, S. Mukherjee, S.S. Rachamalla, and R. Sistla Dendrimer-TPGS mixed micelles for enhanced solubility and cellulartoxicity of taxanes Colloid Surf. B: Biointerfaces 121 2014 461 468
63. D.M. Raut, D.T. Mahajan, D.M. Sakharkar, P.S. Bodke, K.V. Pavan, R. Ravikiran Allada, G. Deshpande, D. Durvas Patil, and A. Patil Water and temperature induced polymorphic transformations of mannitol Int. J. Curr. Res. 3 2011 169 172
64. M.S. Rodde, G.T. Divase, T.B. Devkar, and A.R. Tekade Solubility and bioavailability enhancement of poorly aqueous soluble atorvastatin: in vitro, ex vivo, and in vivo studies Biomed. Res. Int. 2014 463895
65. R. Rosell, E. Felip, R. Garcia-Campelo, and C. Balana The biology of non-smallcell lung cancer: identifying new targets for rational therapy Lung Cancer 46 2004 135 148
66. P. Russo, C. Sacchetti, I. Pasquali, R. Bettini, G. Massimo, P. Colombo, and A. Rossi Primary microparticles and agglomerates of morphine for nasal insufflation J. Pharm. Sci. 95 2006 2553 2561
67. V. Saxena, and M.D. Hussain Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer Int. J. Nanomed. 7 2012 713 721
68. K. Shinoda, M. Araki, A. Sadaghiani, A. Khan, and B. Lindman Lecithin-based microemuisions: phase behavior and microstructure J. Phys. Chem. 95 1991 989 993
69. T. Sou, M.P. McIntosh, L.M. Kaminskas, R.J. Prankerd, and D.A.V. Morton Designing a multicomponent spray-dried formulation platform for pulmonary delivery of biomacromolecules: the effect of polymers on the formation of an amorphous matrix for glassy state stabilization of biomacromolecules Drying Technol. 31 2013 1451 1458
70. W.Q. Sun, and P. Davidson Effect of dextran molecular weight on protein stabilization during freeze-drying and storage Cryo Lett. 22 2001 285 292
71. G. Wang, and T. Wang 2008: Oxidative stability of egg and soy Lecithin as affected by transition metal ions and pH in emulsion J. Agric. Food Chem. 56 2008 11424 11431
72. X.-Y. Xuan, Y.-L. Cheng, and E. Acosta Lecithin-linker microemulsion gelatin gels for extended drug delivery Pharmaceutics 4 2012 104 129
73. J.S. Yuan, M. Ansari, M. Samaan, and E.J. Acosta Linker-based lecithin microemulsions for transdermal delivery of lidocaine Int. J. Pharm. 349 2008 130 143
74. Y. Zhang, W. Zou, F. Cui, N. et al. Wang, D. Zhang, Y. Cui, P. Liu, and J. Liu Protective effect of phosphatidylcholine on restoration of ethanol-injured hepatocytes related with caveolin-1 J. Membr. Biol. 247 2014 73 80