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Volumn 27, Issue 8, 2009, Pages 1230-1241

New approach on the development of a mucosal vaccine against strangles: Systemic and mucosal immune responses in a mouse model

Author keywords

Mucosal vaccine; Nanospheres; Poly(lactic acid); Strangles

Indexed keywords

ALGINIC ACID; BACTERIAL ANTIGEN; BACTERIAL VACCINE; CHITOSAN; DRUG CARRIER; GLYCOLCHITOSAN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; NANOPARTICLE; NANOSPHERE; OLEIC ACID; POLYLACTIC ACID; POLYMER; POLYVINYL ALCOHOL; SPERMINE; UNCLASSIFIED DRUG;

EID: 58749108436     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.12.004     Document Type: Article
Times cited : (32)

References (45)
  • 1
    • 0022921086 scopus 로고
    • Systemic Streptococcus equi infection in a horse handler-a case of human strangles
    • Breiman R., and Silverblatt F. Systemic Streptococcus equi infection in a horse handler-a case of human strangles. West J Med 145 3 (1986) 385-386
    • (1986) West J Med , vol.145 , Issue.3 , pp. 385-386
    • Breiman, R.1    Silverblatt, F.2
  • 2
    • 0141627448 scopus 로고    scopus 로고
    • Streptococcus equi subspecies equi (Lancefield group C) meningitis in a child
    • Welsayed S., Hammerberg O., Massey V., and Hussain Z. Streptococcus equi subspecies equi (Lancefield group C) meningitis in a child. Clin Microbiol Infect 9 8 (2003) 869-872
    • (2003) Clin Microbiol Infect , vol.9 , Issue.8 , pp. 869-872
    • Welsayed, S.1    Hammerberg, O.2    Massey, V.3    Hussain, Z.4
  • 3
    • 13544259813 scopus 로고    scopus 로고
    • Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles
    • Sweeney C.R., Timoney J.F., Newton J.R., and Hines M.T. Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles. J Vet Intern Med 19 (2005) 123-134
    • (2005) J Vet Intern Med , vol.19 , pp. 123-134
    • Sweeney, C.R.1    Timoney, J.F.2    Newton, J.R.3    Hines, M.T.4
  • 4
    • 34248150223 scopus 로고    scopus 로고
    • Getting a grip on strangles: recent progress towards improved diagnostics and vaccines
    • Waller A.S., and Jolley K.A. Getting a grip on strangles: recent progress towards improved diagnostics and vaccines. Vet J 173 3 (2007) 492-501
    • (2007) Vet J , vol.173 , Issue.3 , pp. 492-501
    • Waller, A.S.1    Jolley, K.A.2
  • 5
    • 2542512497 scopus 로고    scopus 로고
    • Recombinant Streptococcus equi proteins protect mice in challenge experiments and induce immune response in horses
    • Flock M., Jacobsson K., Frykberg L., Hirst T.R., Franklin A., Guss B., et al. Recombinant Streptococcus equi proteins protect mice in challenge experiments and induce immune response in horses. Infect Immun 72 6 (2004) 3228-3236
    • (2004) Infect Immun , vol.72 , Issue.6 , pp. 3228-3236
    • Flock, M.1    Jacobsson, K.2    Frykberg, L.3    Hirst, T.R.4    Franklin, A.5    Guss, B.6
  • 6
    • 0033802309 scopus 로고    scopus 로고
    • Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus
    • Harrington D.J., Greated J.S., Chanter N., and Sutcliffe I.C. Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus. Infect Immun 68 10 (2000) 6048-6051
    • (2000) Infect Immun , vol.68 , Issue.10 , pp. 6048-6051
    • Harrington, D.J.1    Greated, J.S.2    Chanter, N.3    Sutcliffe, I.C.4
  • 7
    • 33845499019 scopus 로고    scopus 로고
    • Mutation of the maturase lipoprotein attenuates the virulence of Streptococcus equi to a greater extent than does loss of general lipoprotein lipidation
    • Hamilton A., Robinson C., Sutcliffe I., Slater J., Maskell D.J., Davis-Poynter N., et al. Mutation of the maturase lipoprotein attenuates the virulence of Streptococcus equi to a greater extent than does loss of general lipoprotein lipidation. Infect Immun 74 12 (2006) 6907-6919
    • (2006) Infect Immun , vol.74 , Issue.12 , pp. 6907-6919
    • Hamilton, A.1    Robinson, C.2    Sutcliffe, I.3    Slater, J.4    Maskell, D.J.5    Davis-Poynter, N.6
  • 8
    • 0037154755 scopus 로고    scopus 로고
    • Nasal mucosal immunogenicity for the horse of a SeM peptide of Streptococcus equi genetically coupled to cholera toxin
    • Sheoran A.S., Artiushin S., and Timoney J.F. Nasal mucosal immunogenicity for the horse of a SeM peptide of Streptococcus equi genetically coupled to cholera toxin. Vaccine 20 (2002) 1653-1659
    • (2002) Vaccine , vol.20 , pp. 1653-1659
    • Sheoran, A.S.1    Artiushin, S.2    Timoney, J.F.3
  • 9
    • 0022095553 scopus 로고
    • Serum bactericidal responses to Streptococcus equi of horses following infection or vaccination
    • Timoney J., and Eggers D. Serum bactericidal responses to Streptococcus equi of horses following infection or vaccination. Equine Vet J 17 (1985) 306-310
    • (1985) Equine Vet J , vol.17 , pp. 306-310
    • Timoney, J.1    Eggers, D.2
  • 10
    • 0034668159 scopus 로고    scopus 로고
    • Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system
    • Nally J., Artiushin S., Sheoran A., Burns P.J., Simon B., Gilley R.M., et al. Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system. Vaccine 19 (2001) 492-497
    • (2001) Vaccine , vol.19 , pp. 492-497
    • Nally, J.1    Artiushin, S.2    Sheoran, A.3    Burns, P.J.4    Simon, B.5    Gilley, R.M.6
  • 11
    • 0032867233 scopus 로고    scopus 로고
    • Intranasal immunization against influenza virus using polymeric particles
    • Lemoine D., Deschuyteneer M., Hogge F., and Preat V. Intranasal immunization against influenza virus using polymeric particles. J Biomater Sci Polym Ed 10 (1999) 805-825
    • (1999) J Biomater Sci Polym Ed , vol.10 , pp. 805-825
    • Lemoine, D.1    Deschuyteneer, M.2    Hogge, F.3    Preat, V.4
  • 12
    • 0027461945 scopus 로고
    • Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(l-lactic acid) microspheres in rats, rabbits and guinea-pigs
    • Almeida A.J., Alpar H.O., and Brown M.R.W. Immune response to nasal delivery of antigenically intact tetanus toxoid associated with poly(l-lactic acid) microspheres in rats, rabbits and guinea-pigs. J Pharm Pharmacol 45 (1993) 198-203
    • (1993) J Pharm Pharmacol , vol.45 , pp. 198-203
    • Almeida, A.J.1    Alpar, H.O.2    Brown, M.R.W.3
  • 13
    • 0032374350 scopus 로고    scopus 로고
    • Analysis of local and systemic immunological responses after intra-tracheal, intra-nasal, intra-muscular administration of microsphere co-encapsualted Yersinia pestis sub-unit vaccines
    • Eyles J.E., Spiers I.D., Williamson E.D., and Alpar H.O. Analysis of local and systemic immunological responses after intra-tracheal, intra-nasal, intra-muscular administration of microsphere co-encapsualted Yersinia pestis sub-unit vaccines. Vaccine 16 (1998) 2000-2009
    • (1998) Vaccine , vol.16 , pp. 2000-2009
    • Eyles, J.E.1    Spiers, I.D.2    Williamson, E.D.3    Alpar, H.O.4
  • 14
    • 0036296053 scopus 로고    scopus 로고
    • Recent advances in vaccine adjuvants
    • Singh M., and O'Hagan D.T. Recent advances in vaccine adjuvants. Pharm Res 19 6 (2002) 715-728
    • (2002) Pharm Res , vol.19 , Issue.6 , pp. 715-728
    • Singh, M.1    O'Hagan, D.T.2
  • 15
    • 33646139149 scopus 로고    scopus 로고
    • Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally
    • Jaganathan K.S., and Vyas S.P. Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally. Vaccine 24 19 (2006) 4201-4211
    • (2006) Vaccine , vol.24 , Issue.19 , pp. 4201-4211
    • Jaganathan, K.S.1    Vyas, S.P.2
  • 16
    • 21844435468 scopus 로고    scopus 로고
    • Preparation of coated nanoparticles for a new mucosal vaccine delivery system
    • Borges O., Borchard G., Verhoef jC, Sousa A., and Junginger H.E. Preparation of coated nanoparticles for a new mucosal vaccine delivery system. Int J Pharm 299 (2005) 155-166
    • (2005) Int J Pharm , vol.299 , pp. 155-166
    • Borges, O.1    Borchard, G.2    Verhoef jC3    Sousa, A.4    Junginger, H.E.5
  • 17
    • 34547680472 scopus 로고    scopus 로고
    • Enhancement of intestinal absorption of macromolecules by spermine in rats
    • Sugita Y., Takao K., Toyama Y., and Shirahatal A. Enhancement of intestinal absorption of macromolecules by spermine in rats. Amino Acids 33 (2007) 253-260
    • (2007) Amino Acids , vol.33 , pp. 253-260
    • Sugita, Y.1    Takao, K.2    Toyama, Y.3    Shirahatal, A.4
  • 18
    • 33645232037 scopus 로고    scopus 로고
    • Surfactants in vaccine adjuvants: description and perspectives
    • S2/83-S2/85
    • Ascarateil S., and Dupuis L. Surfactants in vaccine adjuvants: description and perspectives. Vaccine 24S2 (2006) S2/83-S2/85
    • (2006) Vaccine , vol.24 S2
    • Ascarateil, S.1    Dupuis, L.2
  • 19
    • 57549114032 scopus 로고    scopus 로고
    • The enhancement of the immune response against S. equi antigens through the intranasal administration of poly-ε-caprolactone-based nanoparticles
    • Florindo H.F., Pandit S., Lacerda L., Gonçalves L.M.D., Alpar H.O., and Almeida A.J. The enhancement of the immune response against S. equi antigens through the intranasal administration of poly-ε-caprolactone-based nanoparticles. Biomaterials 30 (2009) 879-891
    • (2009) Biomaterials , vol.30 , pp. 879-891
    • Florindo, H.F.1    Pandit, S.2    Lacerda, L.3    Gonçalves, L.M.D.4    Alpar, H.O.5    Almeida, A.J.6
  • 20
    • 47149110539 scopus 로고    scopus 로고
    • S. equi antigens adsorbed onto surface modified poly-caprolactone microspheres induce humoral and cellular specific immune responses
    • Florindo H., Pandit S., Gonçalves L., Alpar H., and Almeida A. S. equi antigens adsorbed onto surface modified poly-caprolactone microspheres induce humoral and cellular specific immune responses. Vaccine 26 (2008) 4168-4177
    • (2008) Vaccine , vol.26 , pp. 4168-4177
    • Florindo, H.1    Pandit, S.2    Gonçalves, L.3    Alpar, H.4    Almeida, A.5
  • 21
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications
    • Towbin H., Staehlin T., and Gordin J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications. Proc Natl Acad Sci USA 76 (1979) 4350-4354
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehlin, T.2    Gordin, J.3
  • 22
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 1-2 (1983) 55-63
    • (1983) J Immunol Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 23
    • 4344697146 scopus 로고    scopus 로고
    • Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors
    • Fifis T., Gamvrellis A., Crimeen-Irwin B., Pietersz G., Li J., and Mottram P. Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors. J Immunol 173 (2004) 3148-3154
    • (2004) J Immunol , vol.173 , pp. 3148-3154
    • Fifis, T.1    Gamvrellis, A.2    Crimeen-Irwin, B.3    Pietersz, G.4    Li, J.5    Mottram, P.6
  • 24
    • 34249043665 scopus 로고    scopus 로고
    • Glycol chitosan as a stabilizer for protein encapsulated into poly(lactide-co-glycolide) microparticle
    • Lee E.S., Park K., Park I.S., and Na K. Glycol chitosan as a stabilizer for protein encapsulated into poly(lactide-co-glycolide) microparticle. Int J Pharm 338 (2007) 310-316
    • (2007) Int J Pharm , vol.338 , pp. 310-316
    • Lee, E.S.1    Park, K.2    Park, I.S.3    Na, K.4
  • 25
    • 0034194497 scopus 로고    scopus 로고
    • Ambiguities in the preclinical quality assessment of microparticulate vaccines
    • Johansen P., Gander B., Merkle H., and Sesardic D. Ambiguities in the preclinical quality assessment of microparticulate vaccines. Trends Biotechnol 18 (2000) 203-211
    • (2000) Trends Biotechnol , vol.18 , pp. 203-211
    • Johansen, P.1    Gander, B.2    Merkle, H.3    Sesardic, D.4
  • 26
    • 0034601247 scopus 로고    scopus 로고
    • Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination
    • Johansen P., Men Y., Merkle H.P., and Gander B. Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination. Eur J Pharm Biopharm 50 1 (2000) 129-146
    • (2000) Eur J Pharm Biopharm , vol.50 , Issue.1 , pp. 129-146
    • Johansen, P.1    Men, Y.2    Merkle, H.P.3    Gander, B.4
  • 27
    • 0033537879 scopus 로고    scopus 로고
    • Induction of cellular immunity to a mycobacterial antigen adsorbed on lamellar particles of lactide polymers
    • Venkataprasad N., Coombes A.G., Singh M., Rohde M., Wilkinson K., Hudecz F., et al. Induction of cellular immunity to a mycobacterial antigen adsorbed on lamellar particles of lactide polymers. Vaccine 17 15-16 (1999) 1814-1819
    • (1999) Vaccine , vol.17 , Issue.15-16 , pp. 1814-1819
    • Venkataprasad, N.1    Coombes, A.G.2    Singh, M.3    Rohde, M.4    Wilkinson, K.5    Hudecz, F.6
  • 28
    • 33747889586 scopus 로고    scopus 로고
    • Microencapsulation of Streptococcus equi antigens in biodegradable microspheres and preliminary immunisation studies
    • Azevedo A.F., Galhardas J., Cunha A., Cruz P., Goncalves L.M., and Almeida A.J. Microencapsulation of Streptococcus equi antigens in biodegradable microspheres and preliminary immunisation studies. Eur J Pharm Biopharm 64 2 (2006) 131-137
    • (2006) Eur J Pharm Biopharm , vol.64 , Issue.2 , pp. 131-137
    • Azevedo, A.F.1    Galhardas, J.2    Cunha, A.3    Cruz, P.4    Goncalves, L.M.5    Almeida, A.J.6
  • 29
    • 0037159628 scopus 로고    scopus 로고
    • Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres
    • Gutierro I., Herandez R., Igartua M., Gascon A., and Pedraz J. Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres. Vaccine 21 (2002) 67-77
    • (2002) Vaccine , vol.21 , pp. 67-77
    • Gutierro, I.1    Herandez, R.2    Igartua, M.3    Gascon, A.4    Pedraz, J.5
  • 30
    • 0032484619 scopus 로고    scopus 로고
    • Large molecule and particulate uptake in nasal cavity: the effect of size on nasal absorption
    • Donovan M.D., and Huang Y. Large molecule and particulate uptake in nasal cavity: the effect of size on nasal absorption. Adv Drug Deliv Rev 29 (1998) 147-155
    • (1998) Adv Drug Deliv Rev , vol.29 , pp. 147-155
    • Donovan, M.D.1    Huang, Y.2
  • 31
    • 0001552479 scopus 로고    scopus 로고
    • Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity
    • Nixon D., Hioe C., Chen P., Bian Z., Kuebler P., Li M.L., et al. Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity. Vaccine 14 (1996) 1523-1530
    • (1996) Vaccine , vol.14 , pp. 1523-1530
    • Nixon, D.1    Hioe, C.2    Chen, P.3    Bian, Z.4    Kuebler, P.5    Li, M.L.6
  • 32
    • 0031060457 scopus 로고    scopus 로고
    • Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery
    • Song C., Labshasetwar V., Murphy H., Qu X., Humphrey W.R., Shebuski J., et al. Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Control Release 43 (1997) 197-212
    • (1997) J Control Release , vol.43 , pp. 197-212
    • Song, C.1    Labshasetwar, V.2    Murphy, H.3    Qu, X.4    Humphrey, W.R.5    Shebuski, J.6
  • 33
    • 23944462440 scopus 로고    scopus 로고
    • Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles
    • Katare Y., Muthukumaran T., and Panda A. Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles. Int J Pharm 301 (2005) 149-160
    • (2005) Int J Pharm , vol.301 , pp. 149-160
    • Katare, Y.1    Muthukumaran, T.2    Panda, A.3
  • 34
    • 0035860620 scopus 로고    scopus 로고
    • Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration
    • Eyles J., Bramwell V., Williamson E., and Alpar H. Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration. Vaccine 19 (2001) 4732-4742
    • (2001) Vaccine , vol.19 , pp. 4732-4742
    • Eyles, J.1    Bramwell, V.2    Williamson, E.3    Alpar, H.4
  • 35
    • 0037435833 scopus 로고    scopus 로고
    • Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro
    • Sun H., Pollock K., and Brewer J. Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro. Vaccine 21 (2003) 849-855
    • (2003) Vaccine , vol.21 , pp. 849-855
    • Sun, H.1    Pollock, K.2    Brewer, J.3
  • 36
    • 0030870842 scopus 로고    scopus 로고
    • Nasal immunization with group B streptococci can induce high levels of specific IgA antibodies in cervicovaginal secretions of mice
    • Hordnes K., Tynning T., Brown T., Haneberg B., and Jonsson R. Nasal immunization with group B streptococci can induce high levels of specific IgA antibodies in cervicovaginal secretions of mice. Vaccine 15 (1997) 1244-1251
    • (1997) Vaccine , vol.15 , pp. 1244-1251
    • Hordnes, K.1    Tynning, T.2    Brown, T.3    Haneberg, B.4    Jonsson, R.5
  • 37
    • 3343026081 scopus 로고    scopus 로고
    • Intranasal co-administration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis
    • Rojas-Hernandez S., Rodriguez-Monroy M., Lopez-Revilla R., Resendiz-Albor A., and Moreno-Fierros L. Intranasal co-administration of the Cry1Ac protoxin with amoebal lysates increases protection against Naegleria fowleri meningoencephalitis. Infect Immun 72 (2004) 4368-4375
    • (2004) Infect Immun , vol.72 , pp. 4368-4375
    • Rojas-Hernandez, S.1    Rodriguez-Monroy, M.2    Lopez-Revilla, R.3    Resendiz-Albor, A.4    Moreno-Fierros, L.5
  • 38
    • 0242317689 scopus 로고    scopus 로고
    • The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines
    • Baudner B.C., Giuliani M.M., Verhoef J.C., Rappuoli R., Junginger H.E., and Giudice G.D. The concomitant use of the LTK63 mucosal adjuvant and of chitosan-based delivery system enhances the immunogenicity and efficacy of intranasally administered vaccines. Vaccine 21 25-26 (2003) 3837-3844
    • (2003) Vaccine , vol.21 , Issue.25-26 , pp. 3837-3844
    • Baudner, B.C.1    Giuliani, M.M.2    Verhoef, J.C.3    Rappuoli, R.4    Junginger, H.E.5    Giudice, G.D.6
  • 39
    • 0032917517 scopus 로고    scopus 로고
    • Effect of chitosan on epithelial permeability and structure
    • Dodane V., Amin K.M., and Merwin J.R. Effect of chitosan on epithelial permeability and structure. Int J Pharm 182 (1999) 21-32
    • (1999) Int J Pharm , vol.182 , pp. 21-32
    • Dodane, V.1    Amin, K.M.2    Merwin, J.R.3
  • 40
    • 9244253168 scopus 로고    scopus 로고
    • Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
    • Jiang W., Gupta R., Deshpande M., and Schwendeman S. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv Drug Deliv Rev 57 (2005) 391-410
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 391-410
    • Jiang, W.1    Gupta, R.2    Deshpande, M.3    Schwendeman, S.4
  • 41
    • 0033559141 scopus 로고    scopus 로고
    • Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production
    • Yanagita M., Hiroi T., Kitagaki N., Hamada S., Ito H., Shimauchi H., et al. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. J Immunol 162 (1999) 3569-3575
    • (1999) J Immunol , vol.162 , pp. 3569-3575
    • Yanagita, M.1    Hiroi, T.2    Kitagaki, N.3    Hamada, S.4    Ito, H.5    Shimauchi, H.6
  • 42
    • 12444254796 scopus 로고    scopus 로고
    • Roles of anti-hemagglutinin IgA and IgG antibodies in different sites of the respiratory tract of vaccinated mice in preventing lethal influenza pneumonia
    • Ito R., Ozaki Y., Yoshikawa T., Hasegawa H., Sato Y., and Suzuki Y. Roles of anti-hemagglutinin IgA and IgG antibodies in different sites of the respiratory tract of vaccinated mice in preventing lethal influenza pneumonia. Vaccine 21 (2003) 2362-2371
    • (2003) Vaccine , vol.21 , pp. 2362-2371
    • Ito, R.1    Ozaki, Y.2    Yoshikawa, T.3    Hasegawa, H.4    Sato, Y.5    Suzuki, Y.6
  • 43
    • 33750379415 scopus 로고    scopus 로고
    • Encapsulation of antigenic extracts of Salmonella enterica serovar Abortusovis into polymeric systems and efficacy as vaccines in mice
    • Estevan M., Irache J., Grillo M., Blasco J., and Gamazo C. Encapsulation of antigenic extracts of Salmonella enterica serovar Abortusovis into polymeric systems and efficacy as vaccines in mice. Vet Microbiol 118 (2006) 124-132
    • (2006) Vet Microbiol , vol.118 , pp. 124-132
    • Estevan, M.1    Irache, J.2    Grillo, M.3    Blasco, J.4    Gamazo, C.5
  • 44
    • 0034663576 scopus 로고    scopus 로고
    • In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity
    • Ludewig B., Barchiesi F., Pericin M., Zinkernagel R., Hengartner H., and Schwendener R. In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity. Vaccine 19 (2000) 23-32
    • (2000) Vaccine , vol.19 , pp. 23-32
    • Ludewig, B.1    Barchiesi, F.2    Pericin, M.3    Zinkernagel, R.4    Hengartner, H.5    Schwendener, R.6
  • 45
    • 32044443144 scopus 로고    scopus 로고
    • Modulating the adjuvanticity of alum by co-administration of muramyl di-peptide (MDP) or Quil-A
    • Moschos S., Bramwell V., Somavarapu S., and Alpar H. Modulating the adjuvanticity of alum by co-administration of muramyl di-peptide (MDP) or Quil-A. Vaccine 24 8 (2006) 1081-1086
    • (2006) Vaccine , vol.24 , Issue.8 , pp. 1081-1086
    • Moschos, S.1    Bramwell, V.2    Somavarapu, S.3    Alpar, H.4


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