Effects of shear stress pattern and magnitude on mesenchymal transformation and invasion of aortic valve endothelial cells

Biotechnology and Bioengineering

Volumn 111, Issue 11, 2014, Pages 2326-2337

  Mahler, Gretchen J ^a,b   Frendl, Christopher M ^a   Cao, Qingfeng ^b   Butcher, Jonathan T ^a  

^a Cornell University   (United States)

^b BINGHAMTON UNIVERSITY   (United States)

Author keywords

3D culture; Endothelial to mesenchymal transformation; Inflammation; Side specific

Indexed keywords

BIOREACTORS; BLOOD VESSELS; CELL ENGINEERING; CELLS; CYTOLOGY; GENE EXPRESSION; HEMODYNAMICS; PATHOLOGY; PHYSIOLOGICAL MODELS; PHYSIOLOGY; SHEAR FLOW; SHEAR STRESS; TISSUE; TISSUE ENGINEERING;

3-D CULTURES; ENDOTHELIAL TO MESENCHYMAL TRANSFORMATION; EXTRACELLULAR MATRICES; INFLAMMATION; MICROFLUIDIC BIOREACTORS; OSCILLATORY SHEAR STRESS; PATHOLOGICAL RESPONSE; SIDE SPECIFIC;

ENDOTHELIAL CELLS;

ALPHA ACTININ 2; ALPHA SMOOTH MUSCLE ACTIN; CD31 ANTIGEN; COLLAGEN TYPE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN 1; INTERCELLULAR ADHESION MOLECULE 1; POLYCARBONATE; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; AORTA VALVE; ARTICLE; BIOREACTOR; CELL CULTURE; CELL DENSITY; CELL INVASION; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; EXPERIMENTAL PIG; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; MALE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SHEAR STRESS; UPREGULATION; ANIMAL; DEVICES; MICROFLUIDICS; ORGAN CULTURE TECHNIQUE; PHYSICAL PHENOMENA; PHYSIOLOGICAL STRESS; PHYSIOLOGY; PIG; PROCEDURES;

GASTROPODA; SUS;

ANIMALS; AORTIC VALVE; BIOREACTORS; ENDOTHELIAL CELLS; MICROFLUIDICS; ORGAN CULTURE TECHNIQUES; PHYSICAL PROCESSES; STRESS, PHYSIOLOGICAL; SWINE;

EID: 84925248678     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25291     Document Type: Article

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