Asymmetric redirection of flow through the heart

Nature

Volumn 404, Issue 6779, 2000, Pages 759-761

  Kilner, Philip J ^a   Yang, Guang Zhong ^a   Wilkest, A John ^b   Mohladdlin, Raad H ^a   Firmin, David N ^a   Yacoub, Magdi H ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b Emerson College   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CORONARY ARTERY BLOOD FLOW; EXERCISE; HEART ATRIUM; HEART OUTPUT; HEART RATE; HEART VENTRICLE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ADULT; CORONARY CIRCULATION; DIASTOLE; HEART ATRIA; HEART VENTRICLES; HEMORHEOLOGY; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; SYSTOLE;

EID: 0034643356     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35008075     Document Type: Article

References (22)

1. Icardo, J. M. Development biology of the vertebrate heart, J. Exp. Zool. 275, 144-161 (1996).
2. Firmin, D. N.et al. In vivo validation of MR velocity imaging, J. Comput. Assist. Tomogr. 11, 751-756 (1987).
3. Firmin, D. N., Nayler, G. L., Kilner, P. J. & Longmore, D. B. The application of phase shifts in NMR for flow measurement. Magn. Reson. Med. 14, 230-241 (1990).
4. Kilner, P. J., Yang, G. Z., Mohiaddin, R. H., Firmin, D. N. & Longmore, D. B. Helical and retrograde secondary flow patterns in the aortic arch studied by three-directional magnetic resonance velocity mapping. Circulation 88, 2235-2247 (1993)
5. Yang, G. Z., Kilner, P. J., Mohiaddin, R. H. & Firmin, D. N. Transient streamlines: texture synthesis for in vivo flow visualisation. Int. J. Cardiac Imag. (in the press).
6. Kilner, P. J., Henein, M. Y. & Gibson, D. G. Our torluous heart in dynamic mode an echocardiographic study of mitral flow and movement in exercising subjects. Heart Vessels 12, 103-110 (1997).
7. Caro, C. G. et al. Non-planar curvature and branching of arteries and non-planar-type flow. Proc. R. Soc. Lond. A 452, 185-197 (1996).
8. Bellhouse, B. J. & Bellhouse, F. H. Fluid mechanics of the mitral valve. Nature 224, 615-616 (1969).
9. Peskin, C, S. & McQueen, D. M. in Case Studies in Mathematical Modelling - Ecology, Physiology, and Cell Biology (eds Othmer, H. G., Adler, F. R., Lewis, M. A. & Dallon, J. C.) 309-337 (Prentice-Hall, Eaglewood Cliffs, NJ, 1996).
10. Taylor, T. W. & Yamaguchi, T. Flow patterns in three dimensional left ventricular systolic and diastolic flows determined from computational fluid dynamics. Biorheology 32, 61-71 (1995).
11. Taylor, D. E. & Wade. J. D, Pattern of blood flow within the heart: a stable system. Cardiovasc. Res. 7, 14-21 (1973).
12. Kim, W. Y. et al. Left ventricular blood flow patterns in normal subjects: a quantitative analysis by three-dimensional magnetic resonance velocity mapping. J. Am. Coll. Cardiol. 26, 224-238 (1995).
13. Ryan, A. K. et al. Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 394, 545-551 (1998).
14. 2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell 94, 307-317 (1998).
15. Noble, M. I. The Frank-Starling curve. Clin. Sci. Mol. Med. 54, 1-7 (1978).
16. Landesberg, A, Molecular control of myocardial mechanics and energetics: the chemo-mechanical conversion. Adv. Exp. Med. Biol. 430, 75-87 (1997).
17. Liang, Y. L. et al. Effects of heart rate on arterial compliance in men. Clin. Exp. Pharmacol. Physiol. 26, 342-346 (1999).
18. Di Bello, V. et al. Left ventricular function during exercise in athletes and in sedentary men. Med. Sci. Sports Exercise 28, 190-196 (1996).
19. Shapiro, L. M. The morphologic consequences of systemic training. Cardiol. Clinics. 15, 373-379 (1997).
20. Yacoub, M. H., Kilner. P. J., Birks, E. J. & Misfeld, M. The aortic outflow and root - a tale of dynamism and crosstalk. Ann. Thorac. Surg. 68, 37-43 (1999).
21. Friedman, M. H., Brinkman, A. M., Qin, J. J. & Seed, W. A, Relation between coronary artery geometry and the distribution of early sudanophilic lesions. Atherosclerosis 98, 193-199 (1993).
22. Kilner, P. J. Morphodynamics of Flow Through the Heart. Thesis, Univ. London (1998).