Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

Aging Cell

Volumn 13, Issue 5, 2014, Pages 828-837

  Jové, Mariona ^a   Naudí, Alba ^a   Ramírez Núñez, Omar ^a   Portero Otín, Manuel ^a   Selman, Colin ^b   Withers, Dominic J ^c   Pamplona, Reinald ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Caloric restriction; Glycolytic pathway; Phospholipids oxidation; Protein oxidative damage; Tryptophan pathway

Indexed keywords

1 PALMITOYL 2 GLUTARYL SN GLYCERO 3 PHOSPHATIATES DYLCHOLINE; CHOLESTEROL; CREATINE; CYTOCHROME C OXIDASE; GLUCOSE; LIPIDOME; LIVER PROTEIN; PHOSPHOETHANOLAMINE; PHOSPHOLIPID; PYRUVIC ACID; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRIACYLGLYCEROL; TRYPTOPHAN; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CALORIC RESTRICTION; CHOLESTEROL BLOOD LEVEL; FATTY ACID ANALYSIS; GLUCOSE BLOOD LEVEL; LIPID ANALYSIS; LIPID COMPOSITION; LIPID METABOLISM; LIPID PEROXIDATION; LIPIDOMICS; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MITOCHONDRION; MALE; METABOLITE; METABOLOMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN ELECTROPHORESIS; REGULATORY MECHANISM; STEADY STATE; TIME OF FLIGHT MASS SPECTROMETRY; TRIACYLGLYCEROL BLOOD LEVEL; AGING; ANIMAL; C57BL MOUSE; LIVER; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PROCEDURES;

MUS;

AGING; ANIMALS; CALORIC RESTRICTION; LIVER; MALE; METABOLOMICS; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; OXIDATIVE STRESS;

EID: 84925235777     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12241     Document Type: Article

References (49)

1. Abbott SK, Else PL, Atkins TA, Hulbert AJ (2012) Fatty acid composition of membrane bilayers: importance of diet polyunsaturated fat balance. Biochim. Biophys. Acta 1818, 1309-1317.
2. Anderson RM, Weindruch R (2010) Metabolic reprogramming, caloric restriction and aging. Trends Endocrinol. Metab. 21, 134-141.
3. Barja G (2013) Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid. Redox Signal. 19, 1420-1445
4. Braidy N, Guillemin GJ, Mansour H, Chan-Ling T, Grant R (2011) Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. FEBS J. 278, 4425-4434.
5. Chen Y, Hagopian K, Bibus D, Villalba JM, López-Lluch G, Navas P, Kim K, McDonald RB, Ramsey JJ (2013) The influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction. Biosci. Rep. 33, 83-95.
6. Chiou S-K, Hoa N, Hodges A (2011) Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury. Biochem. Pharmacol. 81, 1317-1323.
7. Cooper TM, Mockett RJ, Sohal BH, Sohal RS, Orr WC (2004) Effect of caloric restriction on life span of the housefly, Musca domestica. FASEB J. 18, 1591-1593.
8. Dhahbi JM, Kim H-J, Mote PL, Beaver RJ, Spindler SR (2004) Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc. Natl Acad. Sci. USA 101, 5524-5529.
9. Gómez J, Caro P, Naudí A, Portero-Otin M, Pamplona R, Barja G (2007) Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver. Biogerontology 8, 555-566.
10. Gonzalo H, Brieva L, Tatzber F, Jové M, Cacabelos D, Cassanyé A, Lanau-Angulo L, Boada J, Serrano JC, González C, Hernández L, Peralta S, Pamplona R, Portero-Otin M (2012) Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism. J. Neurochem. 123, 622-634.
11. Gottlieb RA, Carreira RS (2010) Autophagy in health and disease. 5. Mitophagy as a way of life. Am. J. Physiol. Cell Physiol. 299, C203-C210.
12. Gredilla R, Barja G (2005) Minireview: the role of oxidative stress in relation to caloric restriction and longevity. Endocrinology 146, 3713-3717.
13. Hugo SE, Cruz-Garcia L, Karanth S, Anderson RM, Stainier DYR, Schlegel A (2012) A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes Dev. 26, 282-293.
14. Hulbert AJ, Faulks SC, Harper JM, Miller RA, Buffenstein R (2006) Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes. Mech. Ageing Dev. 127, 653-657.
15. Hulbert AJ, Pamplona R, Buffenstein R, Buttemer WA (2007) Life and death: metabolic rate, membrane composition, and life span of animals. Physiol. Rev. 87, 1175-1213.
16. Ichimura Y, Kominami E, Tanaka K, Komatsu M (2008) Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy 4, 1063-1066.
17. Itakura E, Mizushima N (2011) p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J. Cell Biol. 192, 17-27.
18. Jové M, Naudí A, Aledo JC, Cabré R, Ayala V, Portero-Otin M, Barja G, Pamplona R (2013) Plasma long-chain free fatty acids predict mammalian longevity. Sci. Rep. 3, 3346.
19. Jové M, Serrano JCE, Ortega N, Ayala V, Anglès N, Reguant J, Morelló JR, Romero MP, Motilva MJ, Prat J, Pamplona R, Portero-Otín M (2011) Multicompartmental LC-Q-TOF-based metabonomics as an exploratory tool to identify novel pathways affected by polyphenol-rich diets in mice. J. Proteome Res. 10, 3501-3512.
20. Kowaltowski AJ (2011) Caloric restriction and redox state: does this diet increase or decrease oxidant production? Redox Rep. 16, 237-241.
21. Laganiere S, Yu BP (1993) Modulation of membrane phospholipid fatty acid composition by age and food restriction. Gerontology 39, 7-18.
22. Lambert AJ, Portero-Otin M, Pamplona R, Merry BJ (2004) Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria. Mech. Ageing Dev. 125, 529-538.
23. Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de CaboR, Fontana L (2013) Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell 12, 645-651.
24. Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R (2010) Dietary interventions to extend life span and health span based on calorie restriction. J. Gerontol. A Biol. Sci. Med. Sci. 65, 695-703.
25. Mitchell TW, Buffenstein R, Hulbert AJ (2007) Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): a comparative study using shotgun lipidomics. Exp. Gerontol. 42, 1053-1062.
26. Naudí A, Jové M, Ayala V, Portero-Otín M, Barja G, Pamplona R (2013) Membrane lipid unsaturation as physiological adaptation to animal longevity. Front. Physiol. 4, 372.
27. Pamplona R (2008) Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity. Biochim. Biophys. Acta 1777, 1249-1262.
28. Pamplona R (2011) Advanced lipoxidation end-products. Chem. Biol. Interact. 192, 14-20.
29. Pamplona R, Prat J, Cadenas S, Rojas C, Pérez-Campo R, López Torres M, Barja G (1996) Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: the pigeon and human case. Mech. Ageing Dev. 86, 53-66.
30. Pamplona R, Portero-Otín M, Riba D, Ruiz C, Prat J, Bellmunt MJ, Barja G (1998) Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J. Lipid Res. 39, 1989-1994.
31. Pamplona R, Barja G, Portero-Otín M (2002) Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation? Ann. N. Y. Acad. Sci. 959, 475-490.
32. Pamplona R, Dalfó E, Ayala V, Bellmunt MJ, Prat J, Ferrer I, Portero-Otín M (2005) Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets. J. Biol. Chem. 280, 21522-21530.
33. Ristow M, Schmeisser S (2011) Extending life span by increasing oxidative stress. Free Radic. Biol. Med. 51, 327-336.
34. Rodriguez-Navarro JA, Cuervo AM (2010) Autophagy and lipids: tightening the knot. Semin. Immunopathol. 32, 343-353.
35. Sana TR, Fischer S, Wohlgemuth G, Katrekar A, Jung K-H, Ronald PC, Fiehn O (2010) Metabolomic and transcriptomic analysis of the rice response to the bacterial blight pathogen Xanthomonas oryzae pv. oryzae. Metabolomics 6, 451-465.
36. Selman C (2014) Dietary restriction and the pursuit of effective mimetics. Proc. Nutr. Soc. 73, 260-270.
37. Selman C, Kerrison ND, Cooray A, Piper MDW, Lingard SJ, Barton RH, Schuster EF, Blanc E, Gems D, Nicholson JK, Thornton JM, Partridge L, Withers DJ (2006) Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiol. Genomics 27, 187-200.
38. Shinmura K, Tamaki K, Sano M, Murata M, Yamakawa H, Ishida H, Fukuda K (2011) Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging. J. Mol. Cell. Cardiol. 50, 117-127.
39. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ (2009) Autophagy regulates lipid metabolism. Nature 458, 1131-1135.
40. Speakman JR, Mitchell SE (2011) Caloric restriction. Mol. Aspects Med. 32, 159-221.
41. Swindell WR (2012) Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res. Rev. 11, 254-270.
42. Trygg J, Holmes E, Lundstedt T (2007) Chemometrics in metabonomics. J. Proteome Res. 6, 469-479.
43. Wijeyesekera A, Selman C, Barton RH, Holmes E, Nicholson JK, Withers DJ (2012) Metabotyping of long-lived mice using 1H NMR spectroscopy. J. Proteome Res. 11, 2224-2235.
44. Wikoff WR, Pendyala G, Siuzdak G, Fox HS (2008) Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques. J. Clin. Invest. 118, 2661-2669.
45. Wohlgemuth SE, Julian D, Akin DE, Fried J, Toscano K, Leeuwenburgh C, Dunn WA (2007) Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation Res. 10, 281-292.
46. Wohlgemuth SE, Seo AY, Marzetti E, Lees HA, Leeuwenburgh C (2010) Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp. Gerontol. 45, 138-148.
47. Xiang L, He G (2011) Caloric restriction and antiaging effects. Ann. Nutr. Metab. 58, 42-48.
48. Yang W, Hekimi S (2010) A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol. 8, e1000556.
49. Zimniak P (2011) Relationship of electrophilic stress to aging. Free Radic. Biol. Med. 51, 1087-1105.