Targeting monocytes and macrophages by means of SPECT and PET

Quarterly Journal of Nuclear Medicine and Molecular Imaging

Volumn 58, Issue 3, 2014, Pages 269-275

  Van De Wiele, C ^a,b   Sathekge, M ^c   Maes, A ^d  

^a GHENT UNIVERSITY   (Belgium)

^b Department of Nuclear Medicine   (France)

^c UNIVERSITY OF PRETORIA   (South Africa)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Emission computed; Macrophages; Monocytes; Product labeling; Single photon; Tomography

Indexed keywords

FOLATE RECEPTOR; MANNOSE RECEPTOR; NANOPARTICLE; PROTEIN; RADIOPHARMACEUTICAL AGENT; TRANSLOCATION PROTEIN; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; HUMAN; IN VITRO STUDY; INFLAMMATORY BOWEL DISEASE; MACROPHAGE; MONOCYTE; NONHUMAN; PACKAGING; POSITRON EMISSION TOMOGRAPHY; REVIEW; RHEUMATOID ARTHRITIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; CELL TRACKING; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIAGNOSTIC USE; IMMUNOLOGY; INFLAMMATION; ISOTOPE LABELING; PATHOLOGY; PROCEDURES; SCINTISCANNING;

ANIMALS; CELL TRACKING; HUMANS; INFLAMMATION; ISOTOPE LABELING; MACROPHAGES; MONOCYTES; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 84925225730     PISSN: 18244785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Swirski FK, Hilgendorf I, Robbins CS.From proliferation to proliferation: Monocyte lineage comes full circle. Semin Immun-opathol 2014 [Epub ahead of print].
2. Galdiero MR, Garlanda C, Jaillon S, Marone G, Mantovani A. Tumor associated macrophages and neutrophils in tumor progression. J Cell Physiol 2013;228:1404-12.
3. Zhou D, Huang C, Lin Z, Zhan S, Kong L, Fang C et al. Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal 2014;26:192-7.
4. Sica A, Mantovani A. Macrophage plasticity and polarization: In vivo Veritas. J Clin Invest 2012;122:787-95.
5. Kennedy A, Fearon U, Veale DJ, Godson C. Macrophages in synovial inflammation. Front Immunol 2011;2:52.
6. Wallace KL, Zheng LB, Kanazawa Y, Shih DQ. Immunopathology of inflammatory bowel disease. World J Gastroenterol 2014;20:6-21.
7. Matheeussen V, Waumans Y, Martinet W, Van Goethem S, Van der Veken P, Scharpé S et al. Dipeptidyl peptidases in atherosclerosis: Expression and role in macrophage differentiation, activation and apoptosis. Basic Res Cardiol 2013;108:350.
8. Komohara Y, Jinushi M, Takeya M. Clinical significance of macrophage heterogeneity in human malignant tumors. Cancer Sci 2013 [Epub ahead of print].
9. Van Hemert FJ, Voermans C, Van Eck-Smit BL, Bennink RJ. Labeling monocytes for imaging chronic inflammation. Q J Nucl Med Mol Imaging 2009;53:78-88.
10. Palestra CJ, Love C, Bhargava KK. Labeled leukocyte imaging: Current status and future directions. Q J Nucl Med Mol Imaging 2009;53:105-23.
11. Signore A, Soroa VA, De Vries EE Radiobelled white blood cells or FDG for imaging on inflammation and infection? Q J Nucl Med Mol Imaging 2009;53:23-5.
12. van Hemert FJ, Thurlings R, Dohmen SE, Voermans C, Tak PP, van Eck-Smit BL et al. Labeling of autologous monocytes with 99mTc-HMPAO at very high specific radioactivity. Nucl Med Biol 2007;34:933-8.
13. Grimm MC, Pullman WE, Bennett GM, Sullivan PJ, Pavli P, Doe WF. Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa. J Gastroenterol Hepatol 1995;10:387-95.
14. Marienhagen J, Hennemann B, Andreesen R, Eilles C. 111In-oxine labelling of tumour-cytotoxic macrophages generated in vitro from circulating blood monocytes: An in vitro evaluation. Nucl Med Commun 1995;16:357-61.
15. Deichen JT, Prante O, Gack M, Schmiedehausen K, Kuwert T. Uptake of [18F]fluorodeoxyglucose in human monocyte-macrophages in vitro. Eur J Nucl Med Mol Imaging 2003;30:267-73.
16. Hilgendorf I, Swirski FK.A Folate receptor: A macrophage "Achilles' heel"? 2012;1:e004036.
17. Panwar P, Srivastava V, Tandon V, Mishra P, Chuttani K, Sharma R et al. 99mTc-Labeled tetraethylenepentamine-folate. Molecular Imaging and Contrast Agent Database (MICAD) [Internet], Bethesda, MD: National Center for Biotechnology Information (US); 2004-2013.
18. Chopra A. ""Tc-labeled peptide derivative of folic acid. Molecular imaging and contrast agent database (MICAD) [Internet]. Bethesda, MD: National Center for Biotechnology Information (US); 2004-2013.
19. Henne WA, Rothenbuhler R, Ayala-Lopez W, Xia W, Varghese B, Low PS. Imaging sites of infection using a 99mTc-labeled folate conjugate targeted to folate receptor positive macrophages. Mol Pharm 2012;9:1435-40.
20. Piscaer TM, Müller C, Mindt TL, Lubberts E, Verhaar JA, Krenning EP et al. Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography. Arthritis Rheum 2011;63:1898-907.
21. Fischer CR, Müller C, Reber J, Müller A, Krämer SD, Ametamey SM et al. [18F]fluoro-deoxy-glucose folate: A novel PET radiotracer with improved in vivo properties for folate receptor targeting. Bioconjug Chem 2012;23:805-13.
22. Martinez-Pomares L. The mannose receptor. J Leukoc Biol 2012;92:1177-86.
23. Locke LW, Mayo MW, Yoo AD, Williams MB, Berr SS. PET imaging of tumor associated macrophages using mannose coated 64Cu liposomes. Biomaterials 2012;33:7785-93.
24. Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K et al. Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages. Cancer Res 2012;72:4165-77.
25. Ueno T, Dutta P, Keliher E, Leuschner F, Majmudar M, Marinelli B et al. Nanoparticle PET-CT detects rejection and immunomodu-lation in cardiac allografts. Circ Cardiovasc Imaging 2013;6:568-73.
26. Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B et al. Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circ Res 2013;112:755-61.
27. Trapani A, Palazzo C, de Candia M, Lasorsa FM, Trapani G. Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. Bioconjug Chem 2013;24:1415-28.
28. Miot-Noirault E, Perin F, Routledge L, Normier G, Le Pape A. Macrophage targeting with technetium-99m labeled J001 acyl-ated poly-galactoside for scintigraphy of inflammation: Optimization and assessment of imaging specificity in experimental arthritis. Eur J Nucl Med 1996;23:61-8.
29. Perin F, Routledge L, N'Doye O, M'Bodj M, Normier G, Le Pape A. Influence of technetium-99m-labeling conditions on physico-chemical and related biological properties of an acylated poly-galactosidic macrophage targeting agent for inflammation imaging. Nucl Med Biol 1996;23:947-55.
30. Goupille P, Chevalier X, Valat JP, Garaud P, Perin F, Le Pape A. Macrophage targeting with 99mTc-labeled J001 for scintigraphy assessment of experimental osteoarthritis in the rabbit. Br J Rheumatol 1997;36:758-62.
31. Härtung D, Petrov A, Haider N, Fujimoto S, Blankenberg F, Fujimoto A et al. Radiolabeled Monocyte Chemotactic Protein 1 for the detection of inflammation in experimental atherosclerosis. J Nucl Med 2007;48:1816-21.
32. Ishino S, Mukai T, Kuge Y, Kume N, Ogawa M, Takai N et al. Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: Potential agent for imaging of vulnerable plaque. J Nucl Med 2008;49:1677-85.
33. Temma T, Saji H. Radiolabeled probes for imaging of atherosclerotic plaques. Am J Nucl Med Mol Imaging 2012;2:432-47.
34. Bennink RJ, Thurlings RM, van Hemert FJ, Voermans C, Dohmen SE, van Eck-Smit BL et al. Biodistribution and radiation dosimetry of ""Tc-HMPAO-labeled monocytes in patients with rheumatoid arthritis. J Nucl Med 2008;49:1380-5.
35. Thurlings RM, Wijbrandts CA, Bennink RJ, Dohmen SE, Voermans C, Wouters D et al. Monocyte scintigraphy in rheumatoid arthritis: The dynamics of monocyte migration in immune-mediated inflammatory disease. PLoS One 2009;4:e7865.
36. Herenius MM, Thurlings RM, Wijbrandts CA, Bennink RJ, Dohmen SE, Voermans C et al. Monocyte migration to the synovium in rheumatoid arthritis patients treated with adalimumab. Ann Rheum Dis 2011;70:1160-2.
37. Bazzichi L, Betti L, Giannaccini G, Rossi A, Lucacchini A. Peripheral-type benzodiazepine receptors in human mononuclear cells of patients affected by osteoarthritis, rheumatoid arthritis or psoriasic arthritis. Clin Biochem 2003;36:57-60.
38. van der Laken CJ, Elzinga EH, Kropholler MA, Molthoff CF, van der Heijden JW et al. Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography. Arthritis Rheum 2008;58:3350-5.
39. Matteson EL, Lowe VJ, Prendergast FG, Crowson CS, Moder KG, Morgenstern DE et al. Assessment of disease activity in rheumatoid arthritis using a novel folate targeted radiopharmaceutical Folatescan. Clin Exp Rheumatol 2009;27:253-9.
40. Bird JL, Izquierdo-Garcia D, Davies JR, Rudd JH, Probst KC, Figg N et al. Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis. Atherosclerosis 2010;210:388-91.
41. Gaemperli O, Shalhoub J, Owen DR, Lamare F, Johansson S, Fouladi N et al. Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/ computed tomography. Eur Heart J 2012;33:1902-10.