Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques

Circulation Research

Volumn 112, Issue 5, 2013, Pages 755-761

  Majmudar, Maulik D ^a,b   Yoo, Jeongsoo ^a,c   Keliher, Edmund J ^a   Truelove, Jessica J ^a   Iwamoto, Yoshiko ^a   Sena, Brena ^a   Dutta, Partha ^a   Borodovsky, Anna ^d   Fitzgerald, Kevin ^d   Di Carli, Marcelo F ^b   Libby, Peter ^b   Anderson, Daniel G ^e,f,g   Swirski, Filip K ^a   Weissleder, Ralph ^a,h   Nahrendorf, Matthias ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Kyungpook National University School of Medicine   (South Korea)

^d ALNYLAM PHARMACEUTICALS   (United States)

^e David H Koch Institute for Integrative Cancer Research   (United States)

^f David H Koch Institute for Integrative Cancer Research ^*  (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

Author keywords

atherosclerosis; inflammation; macrophage; molecular imaging; nanoparticles; PET MRI

Indexed keywords

APOLIPOPROTEIN E; CD11B ANTIGEN; CHEMOKINE RECEPTOR CCR2; DEFEROXAMINE; DEXTRAN; FLUOROCHROME; NANOPARTICLE; POLYMER; SMALL INTERFERING RNA; ZIRCONIUM DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ROOT; ARTICLE; ATHEROSCLEROTIC PLAQUE; AUTORADIOGRAPHY; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; AORTA; APOLIPOPROTEINS E; DEXTRANS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEASIBILITY STUDIES; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MICE; MICE, KNOCKOUT; NANOPARTICLES; PLAQUE, ATHEROSCLEROTIC; POSITRON-EMISSION TOMOGRAPHY; RADIOISOTOPES; SENSITIVITY AND SPECIFICITY; ZIRCONIUM;

EID: 84874785645     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.300576     Document Type: Article

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