Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB

Life Sciences

Volumn 127, Issue , 2015, Pages 90-97

  Matteucci, Claudia ^a   Minutolo, Antonella ^a,d   Marino Merlo, Francesca ^b   Grelli, Sandro ^a   Frezza, Caterina ^a   Mastino, Antonio ^b,c   Macchi, Beatrice ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^d Laboratory of Molecular Virology and Oncology   (Italy)

Author keywords

Apoptosis; AZT; Bcl 2; Chemotherapy; NF kB

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; CYTOCHROME C; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; SYNAPTOTAGMIN I; ZIDOVUDINE; APOPTOSIS REGULATORY PROTEIN; NITRILE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SULFONE; TRANSCRIPTION FACTOR RELA;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; DRUG MECHANISM; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; PROTO ONCOGENE; TUMOR CELL CULTURE; U937 CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CYTOCHROMES C; GENES, BCL-2; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; NITRILES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE INHIBITORS; SULFONES; TRANSCRIPTION FACTOR RELA; TUMOR CELLS, CULTURED; U937 CELLS; ZIDOVUDINE;

EID: 84925156559     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.01.038     Document Type: Article

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