Potentiation of anti-cancer effect by intravenous administration of vesiculated α-tocopheryl hemisuccinate on mouse melanoma in vivo

Cancer Letters

Volumn 192, Issue 1, 2003, Pages 19-24

  Kogure, Kentaro ^a   Manabe, Sachie ^a   Hama, Susumu ^a   Tokumura, Akira ^a   Fukuzawa, Kenji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Anti cancer agent; Apoptosis; Mouse melanoma; Prevention of tumor growth; Tocopheryl hemisuccinate

Indexed keywords

ALPHA TOCOPHERYL HEMISUCCINATE; ANTINEOPLASTIC AGENT; DIMETHYL SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; INTERMETHOD COMPARISON; MELANOMA; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TREATMENT OUTCOME; TUMOR GROWTH;

EID: 0037456691     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00683-3     Document Type: Article

References (20)

1. Suzuki Y.J., Packer L. Inhibition of NF-κB activation by vitamin E derivatives. Biochem. Biophys. Res. Commun. 193:1993;277-283.
2. Kogure K., Morita M., Hama S., Nakashima S., Tokumura A., Fukuzawa K. Enhancement by α-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-γ through up-regulation of protein kinase C in rat vascular smooth muscle cells. Eur. J. Biochem. 269:2002;2367-2372.
3. Fariss M.W., Fortuna M.B., Everett C.K., Smith J.D., Trent D.F., Djuric Z. The selective antiproliferative effects of α-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds. Cancer Res. 54:1994;3346-3351.
4. Turley J.M., Funakoshi S., Ruscetti F.W., Kasper J., Murphy W.J., Longo D.L., Birchenall-Roberts M.C. Growth inhibition and apoptosis of RL human B lymphoma cells by vitamin E succinate and retinoic acid: role for transforming growth factor-β Cell Growth Differ. 6:1995;655-663.
5. Qian M., Kralova J., Yu W., Bose H.R. Jr., Dvorak M., Sanders B.G., Kline K. c-Jun involvement in vitamin E succinate induced apoptosis of reticuloendotheliosis virus transformed avian lymphoid cells. Oncogene. 15:1997;223-230.
6. Turley J.M., Fu T., Ruscetti F.W., Mikovits J.A., Bertolette D.C. III, Birchenall-Roberts M.C. Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells. Cancer Res. 57:1997;881-890.
7. Yu W., Israel K., Liao Q.Y., Aldaz C.M., Sanders B.G., Kline K. Vitamin E succinate (VES) induced Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res. 59:1999;953-961.
8. 2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells. Cancer Res. 61:2001;6569-6576.
9. Kogure K., Morita M., Nakashima S., Hama S., Tokumura A., Fukuzawa K. Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by α-tocopheryl hemisuccinate. Biochim. Biophys. Acta. 1528:2001;25-30.
10. Neuzil J., Weber T., Terman A., Weber C., Brunk U.T. Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role. Redox Rep. 6:2001;143-151.
11. Neuzil J., Weber T., Gellert N., Weber C. Selective cancer cell killing by α-tocopheryl succinate. Br. J. Cancer. 84:2001;87-89.
12. Weber T., Lu M., Andera L., Lahm H., Gellert N., Fariss M.W., Korinek V., Sattler W., Ucker D.S., Terman A., Schröder A., Erl W., Brunk U.T., Coffey R.J., Weber C., Neuzil J. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin. Cancer Res. 8:2002;863-869.
13. Kogure K., Hama S., Manabe S., Tokumura A., Fukuzawa K. High cytotoxicity of α-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems. Cancer Lett. 186:2002;151-156.
14. Malafa M.P., Neitzel L.T. Vitamin E succinate promotes breast cancer tumor dormancy. J. Surg. Res. 93:2000;163-170.
15. Malafa M.P., Fokum F.D., Mowlavi A., Abusief M., King M. Vitamin E inhibits melanoma growth in mice. Surgery. 131:2002;85-91.
16. Jizomoto H., Kanaoka E., Hirano K. pH-Sensitive liposomes composed of tocopherol hemisuccinate and of phosphatidylethanolamine including tocopherol hemisuccinate. Biochim. Biophys. Acta. 1213:1994;343-348.
17. Allen T.M. Liposomes: opportunities in drug delivery. Drugs. 54:1997;8-14.
18. Fariss M.W., Bryson K.F., Hylton E.H., Lippman H.R., Stubin C.H., Zhao X.G. Protection against carbon tetrachloride-induced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol. Environ. Health Perspect. 101:1993;528-536.
19. Kidao S., Sanders B.G., Kline K. RRR-α-Tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. Biotechnol. Ther. 4:1993;117-132.
20. Ossendorp F., Toes R.E.M., Offringa R., van der Burg S.H., Melief C.J.M. Importance of CD4+ T helper cell responses in tumor immunity. Immunol. Lett. 74:2000;75-79.