Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 32, 2011, Pages 13224-13229

  Legrand, Nicolas ^a,b   Huntington, Nicholas D ^c,d   Nagasawa, Maho ^a   Bakker, Arjen Q ^b   Schotte, Remko ^a,e   Strick Marchand, Hélène ^c,d   De Geus, Sandra J ^f   Pouw, Stephan M ^a   Böhne, Martino ^a,b   Voordouw, Arie ^a   Weijer, Kees ^a   Di Santo, James P ^c,d   Spits, Hergen ^a,b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b AIMM Therapeutics   (Netherlands)

^c INSTITUT PASTEUR   (France)

^d INSTITUT PASTEUR   (France)

^e NETHERLANDS CANCER INSTITUTE   (Netherlands)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Hematopoiesis; Humanized mice; Leukocyte homeostasis

Indexed keywords

CD47 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 2 RECEPTOR GAMMA; RAG2 PROTEIN; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; ENGRAFTMENT; GENETIC TRANSDUCTION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IN VIVO STUDY; LYMPHOID ORGAN; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY T LYMPHOCYTE; MOUSE; NATURAL KILLER CELL; NEWBORN; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEADY STATE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD47; ANTIGENS, DIFFERENTIATION; B-LYMPHOCYTES; DNA-BINDING PROTEINS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; KILLER CELLS, NATURAL; KINETICS; LYMPHOPOIESIS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-2; SPLEEN; SURVIVAL ANALYSIS; T-LYMPHOCYTES; THYMUS GLAND; TRANSPLANTATION, HETEROLOGOUS;

MUS;

EID: 80051982736     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101398108     Document Type: Article

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