Conjugation of Cell-Penetrating Peptides to Parathyroid Hormone Affects Its Structure, Potency, and Transepithelial Permeation

Bioconjugate Chemistry

Volumn 26, Issue 3, 2015, Pages 477-488

  Kristensen, Mie ^a   De Groot, Anne Marit ^b   Berthelsen, Jens ^a   Franzyk, Henrik ^a   Sijts, Alice ^b   Nielsen, Hanne Morck ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ESCHERICHIA COLI; MONOLAYERS; PEPTIDES;

ACTIVE PARTS; CACO-2 CELLS; CELL CULTURE MODELS; CELL IMMUNOGENICITY; CELL-PENETRATING PEPTIDE; FUSION PEPTIDES; PARATHYROID HORMONES; SAOS-2 CELLS; SECONDARY STRUCTURES; THERAPEUTIC PEPTIDES AND PROTEINS;

CELL CULTURE;

CELL PENETRATING PEPTIDE; PARATHYROID HORMONE;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOLOGICAL ACTIVITY; CACO 2 CELL LINE; CARBOXY TERMINAL SEQUENCE; CELL INCLUSION; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CIRCULAR DICHROISM; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; ESCHERICHIA COLI; IMMUNE RESPONSE; IMMUNOGENICITY; IN VITRO STUDY; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; SAOS 2 CELL LINE; TRANSEPITHELIAL PERMEATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY;

ESCHERICHIA COLI;

ANIMALS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELL-PENETRATING PEPTIDES; CELLS, CULTURED; HUMANS; MICE; MICE, INBRED C57BL; PARATHYROID HORMONE;

EID: 84924993282     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc5005763     Document Type: Article

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