Cardiovascular Consequences of Childhood Obesity

Canadian Journal of Cardiology

Volumn 31, Issue 2, 2015, Pages 124-130

  McCrindle, Brian W ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHROPOMETRY; ATHEROSCLEROSIS; CARDIOMETABOLIC RISK; CHILDHOOD OBESITY; HEALTH CARE COST; HEALTH CARE POLICY; HUMAN; OBESITY; OXIDATIVE STRESS; REVIEW; AGE; CARDIOVASCULAR DISEASES; CHILD; COMPLICATION; HEALTH; MORBIDITY; PEDIATRIC OBESITY; RISK FACTOR; TRENDS;

AGE FACTORS; CARDIOVASCULAR DISEASES; CHILD; GLOBAL HEALTH; HUMANS; MORBIDITY; PEDIATRIC OBESITY; RISK FACTORS;

EID: 84924935946     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2014.08.017     Document Type: Review

References (70)

1. Janssen I. The public health burden of obesity in Canada. Can J Diabetes 2013, 37:90-96.
2. Anis A.H., Zhang W., Bansback N., et al. Obesity and overweight in Canada: an updated cost-of-illness study. Obes Rev 2010, 11:31-40.
3. Janssen I., Shields M., Craig C.L., Tremblay M.S. Changes in the obesity phenotype within Canadian children and adults, 1981 to 2007-2009. Obesity (Silver Spring) 2012, 20:916-919.
4. Janssen I., Shields M., Craig C.L., Tremblay M.S. Prevalence and secular changes in abdominal obesity in Canadian adolescents and adults, 1981 to 2007-2009. Obes Rev 2011, 12:397-405.
5. Roberts K.C., Shields M., de Groh M., Aziz A., Gilbert J.A. Overweight and obesity in children and adolescents: results from the 2009 to 2011 Canadian Health Measures Survey. Health Rep 2012, 23:37-41.
6. Ng M., Fleming T., Robinson M., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014, 384:766-781.
7. Deshmukh-Taskar P., Nicklas T.A., Morales M., et al. Tracking of overweight status from childhood to young adulthood: the Bogalusa Heart Study. Eur J Clin Nutr 2006, 60:48-57.
8. Wang Y., Beydoun M.A., Liang L., Caballero B., Kumanyika S.K. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 2008, 16:2323-2330.
9. Interventions for the Prevention or Management of Childhood Obesity: A Review of the Clinical Evidence. Canadian Agency for Drugs and Technologies in Health: Ottawa,2013.
10. Segovia S.A., Vickers M.H., Gray C., Reynolds C.M. Maternal obesity, inflammation, and developmental programming. Biomed Res Int 2014, 2014:418975.
11. Dong M., Zheng Q., Ford S.P., Nathanielsz P.W., Ren J. Maternal obesity, lipotoxicity and cardiovascular diseases in offspring. JMol Cell Cardiol 2013, 55:111-116.
12. Skilton M.R., Marks G.B., Ayer J.G., et al. Weight gain in infancy and vascular risk factors in later childhood. Pediatrics 2013, 131:e1821-e1828.
13. Skilton M.R., Sullivan T.R., Ayer J.G., et al. Weight gain in infancy is associated with carotid extra-medial thickness in later childhood. Atherosclerosis 2014, 233:370-374.
14. Evelein A.M., Visseren F.L., van der Ent C.K., Grobbee D.E., Uiterwaal C.S. Excess early postnatal weight gain leads to thicker and stiffer arteries in young children. JClin Endocrinol Metab 2013, 98:794-801.
15. Owen C.G., Martin R.M., Whincup P.H., Smith G.D., Cook D.G. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics 2005, 115:1367-1377.
16. Potter C.M., Ulijaszek S.J. Predicting adult obesity from measures in earlier life. JEpidemiol Community Health 2013, 67:1032-1037.
17. Shields M., Tremblay M.S. Canadian childhood obesity estimates based on WHO, IOTF and CDC cut-points. Int J Pediatr Obes 2010, 5:265-273.
18. Reilly J.J. Assessment of obesity in children and adolescents: synthesis of recent systematic reviews and clinical guidelines. JHum Nutr Diet 2010, 23:205-211.
19. Javed A, Jumean M, Murad MH, etal. Diagnostic performance of body mass index to identify obesity as defined by body adiposity in children and adolescents: a systematic review and meta-analysis [e-pub ahead of print]. Pediatr Obes . doi:10.1111/ijpo.242.
20. Neovius M., Linne Y., Rossner S. BMI, waist-circumference and waist-hip-ratio as diagnostic tests for fatness in adolescents. Int J Obes (Lond) 2005, 29:163-169.
21. Khoury M., Manlhiot C., Dobbin S., et al. Role of waist measures in characterizing the lipid and blood pressure assessment of adolescents classified by body mass index. Arch Pediatr Adolesc Med 2012, 166:719-724.
22. Khoury M., Manlhiot C., McCrindle B.W. Role of the waist/height ratio in the cardiometabolic risk assessment of children classified by body mass index. JAm Coll Cardiol 2013, 62:742-751.
23. Lim S., Meigs J.B. Links between ectopic fat and vascular disease in humans. Arterioscler Thromb Vasc Biol 2014, 34:1820-1826.
24. Cohen M., Syme C., Deforest M., et al. Ectopic fat in youth: the contribution of hepatic and pancreatic fat to metabolic disturbances. Obesity (Silver Spring) 2014, 22:1280-1286.
25. Brumbaugh D.E., Crume T.L., Nadeau K., Scherzinger A., Dabelea D. Intramyocellular lipid is associated with visceral adiposity, markers of insulin resistance, and cardiovascular risk in prepubertal children: the EPOCH study. JClin Endocrinol Metab 2012, 97:E1099-E1105.
26. Manco M., Morandi A., Marigliano M., et al. Epicardial fat, abdominal adiposity and insulin resistance in obese pre-pubertal and early pubertal children. Atherosclerosis 2013, 226:490-495.
27. Bays H.E. Adiposopathy is "sick fat" a cardiovascular disease?. JAm Coll Cardiol 2011, 57:2461-2473.
28. Olza J., Aguilera C.M., Gil-Campos M., et al. Waist-to-height ratio, inflammation and CVD risk in obese children. Public Health Nutr 2014, 2:1-8.
29. Friedemann C., Heneghan C., Mahtani K., et al. Cardiovascular disease risk in healthy children and its association with body mass index: systematic review and meta-analysis. BMJ 2012, 345:e4759.
30. Maximova K., Kuhle S., Davidson Z., Fung C., Veugelers P.J. Cardiovascular risk-factor profiles of normal and overweight children and adolescents: insights from the Canadian Health Measures Survey. Can J Cardiol 2013, 29:976-982.
31. Montero D., Walther G., Perez-Martin A., Roche E., Vinet A. Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: markers and effect of lifestyle intervention. Obes Rev 2012, 13:441-455.
32. Steinberger J., Daniels S.R., Eckel R.H., et al. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2009, 119:628-647.
33. Magnussen C.G., Koskinen J., Chen W., et al. Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: the Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study. Circulation 2010, 122:1604-1611.
34. Poirier P., Giles T.D., Bray G.A., et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006, 113:898-918.
35. Newman W.P., Freedman D.S., Voors A.W., et al. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study. NEngl J Med 1986, 314:138-144.
36. Berenson G.S., Srinivasan S.R., Bao W., et al. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. NEngl J Med 1998, 338:1650-1656.
37. McGill H.C., McMahan C.A. Determinants of atherosclerosis in the young. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Am J Cardiol 1998, 82:30T-36T.
38. McGill H.C., McMahan C.A., Herderick E.E., et al. Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation 2002, 105:2712-2718.
39. Urbina E.M., Williams R.V., Alpert B.S., et al. Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association. Hypertension 2009, 54:919-950.
40. Cote A.T., Harris K.C., Panagiotopoulos C., Sandor G.G., Devlin A.M. Childhood obesity and cardiovascular dysfunction. JAm Coll Cardiol 2013, 62:1309-1319.
41. Freedman D.S., Patel D.A., Srinivasan S.R., et al. The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study. Int J Obes (Lond) 2008, 32:749-756.
42. Juonala M., Magnussen C.G., Venn A., et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium. Circulation 2010, 122:2514-2520.
43. Alp H., Karaarslan S., Selver Eklioglu B., et al. Association between nonalcoholic fatty liver disease and cardiovascular risk in obese children and adolescents. Can J Cardiol 2013, 29:1118-1125.
44. Koopman L.P., McCrindle B.W., Slorach C., et al. Interaction between myocardial and vascular changes in obese children: a pilot study. JAm Soc Echocardiogr 2012, 25:401-410.e1.
45. Di Salvo G., Pacileo G., Del Giudice E.M., et al. Abnormal myocardial deformation properties in obese, non-hypertensive children: an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study. Eur Heart J 2006, 27:2689-2695.
46. Tapp R.J., Venn A., Huynh Q.L., et al. Impact of adiposity on cardiac structure in adult life: the childhood determinants of adult health (CDAH) study. BMC Cardiovasc Disord 2014, 14:79.
47. Bazzano L.A., Belame S.N., Patel D.A., et al. Obesity and left ventricular dilatation in young adulthood: the Bogalusa Heart Study. Clin Cardiol 2011, 34:153-159.
48. Watts K., Beye P., Siafarikas A., et al. Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. JAm Coll Cardiol 2004, 43:1823-1827.
49. Watts K., Beye P., Siafarikas A., et al. Effects of exercise training on vascular function in obese children. JPediatr 2004, 144:620-625.
50. Kelly A.S., Wetzsteon R.J., Kaiser D.R., et al. Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise. JPediatr 2004, 145:731-736.
51. Woo K.S., Chook P., Yu C.W., et al. Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation 2004, 109:1981-1986.
52. Meyer A.A., Kundt G., Lenschow U., Schuff-Werner P., Kienast W. Improvement of early vascular changes and cardiovascular risk factors in obese children after a six-month exercise program. JAm Coll Cardiol 2006, 48:1865-1870.
53. Kelishadi R., Hashemi M., Mohammadifard N., Asgary S., Khavarian N. Association of changes in oxidative and proinflammatory states with changes in vascular function after a lifestyle modification trial among obese children. Clin Chem 2008, 54:147-153.
54. Farpour-Lambert N.J., Aggoun Y., Marchand L.M., et al. Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children. JAm Coll Cardiol 2009, 54:2396-2406.
55. Murphy E.C., Carson L., Neal W., et al. Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children. Int J Pediatr Obes 2009, 4:205-214.
56. Park J.H., Miyashita M., Kwon Y.C., et al. A12-week after-school physical activity programme improves endothelial cell function in overweight and obese children: a randomised controlled study. BMC Pediatr 2012, 12:111.
57. Huang F., del-Rio-Navarro B.E., de Castro G.T., et al. Weight loss induced by 6-month lifestyle intervention improves early endothelial activation and fibrinolysis in obese adolescents. Child Care Health Dev 2011, 37:377-384.
58. Li S., Chen W., Srinivasan S.R., Xu J., Berenson G.S. Relation of childhood obesity/cardiometabolic phenotypes to adult cardiometabolic profile: the Bogalusa Heart Study. Am J Epidemiol 2012, 176(suppl 7):S142-S149.
59. Kramer C.K., Zinman B., Retnakaran R. Are metabolically healthy overweight and obesity benign conditions? A systematic review and meta-analysis. Ann Intern Med 2013, 159:758-769.
60. Chang Y., Kim B.K., Yun K.E., et al. Metabolically-healthy obesity and coronary artery calcification. JAm Coll Cardiol 2014, 63:2679-2686.
61. Oude Luttikhuis H., Baur L., Jansen H., et al. Interventions for treating obesity in children. Cochrane Database Syst Rev 2009, CD001872.
62. Whitlock E.P., O'Connor E.A., Williams S.B., Beil T.L., Lutz K.W. Effectiveness of weight management interventions in children: a targeted systematic review for the USPSTF. Pediatrics 2010, 125:e396-e418.
63. Viner R.M., Hsia Y., Tomsic T., Wong I.C. Efficacy and safety of anti-obesity drugs in children and adolescents: systematic review and meta-analysis. Obes Rev 2010, 11:593-602.
64. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 2011, 128(suppl 5):S213-S256. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, National Heart, Lung, and Blood InstituteNational Heart, Lung, and Blood Institute.
65. Copeland K.C., Silverstein J., Moore K.R., et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics 2013, 131:364-382.
66. McDonagh M.S., Selph S., Ozpinar A., Foley C. Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger. JAMA Pediatr 2014, 168:178-184.
67. Halbach S.M., Flynn J. Treatment of obesity-related hypertension in children and adolescents. Curr Hypertens Rep 2013, 15:224-231.
68. Kennedy M.J., Jellerson K.D., Snow M.Z., Zacchetti M.L. Challenges in the pharmacologic management of obesity and secondary dyslipidemia in children and adolescents. Paediatr Drugs 2013, 15:335-342.
69. McCrindle B.W., Tyrrell P.N., Kavey R.E. Will obesity increase the proportion of children and adolescents recommended for a statin?. Circulation 2013, 128:2162-2165.
70. Robinson J.G., Gidding S.S. Curing atherosclerosis should be the next major cardiovascular prevention goal. JAm Coll Cardiol 2014, 63:2779-2785.