Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents

Journal of the American College of Cardiology

Volumn 43, Issue 10, 2004, Pages 1823-1827

  Watts, Katie ^a   Beye, Petra ^b   Siafarikas, Aris ^b   Davis, Elizabeth A ^b,c   Jones, Timothy W ^b,c   O'Driscoll, Gerard ^a,d   Green, Daniel J ^a,d  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d ROYAL PERTH HOSPITAL   (Australia)

Author keywords

blood pressure; BMI; body mass index; BP; circuit training; CT; DEXA; dual energy X ray absorptiometry; flow mediated dilation; FMD; glycosylated hemoglobin; HbA1c; HDL; heart rate; high density lipoprotein; HR; LDL; low density lipoprotein; nitric oxide; NO

Indexed keywords

ABDOMEN; ADOLESCENT; ANTHROPOMETRY; ARTICLE; ATHEROSCLEROSIS; BODY COMPOSITION; BODY FAT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; ECHOGRAPHY; EXERCISE; FEMALE; FITNESS; HUMAN; MALE; MUSCLE STRENGTH; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TRUNK; VASCULAR DISEASE; VASODILATATION;

ADIPOSE TISSUE; ADOLESCENT; CROSS-OVER STUDIES; ENDOTHELIUM, VASCULAR; EXERCISE THERAPY; FEMALE; HUMANS; MALE; OBESITY; VASCULAR DISEASES;

EID: 2342664831     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2004.01.032     Document Type: Article

References (19)

1. Eckel R.H., Krauss R.M. American Heart Association call to action obesity as a major risk factor for coronary heart disease. Circulation. 97:1998;2099-2100
2. Schonfeld-Warden N., Warden C.H. Pediatric obesity an overview of etiology and treatment. Pediatr Endocrinol. 44:1997;339-360
3. Vita J.A., Keaney J.F. Endothelial function a barometer for cardiovascular risk. (editorial)? Circulation. 106:2002;640-642
4. Celermajer D.S., Sorensen K.E., Georgakopoulos D., et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 88:1993;2149-2155
5. Celermajer D.S., Sorensen K., Ryalls M., et al. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not their heterozygous parents. J Am Coll Cardiol. 22:1993;854-858
6. Sorensen K.E., Celermajer D.S., Georgakopoulos D., et al. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein (a) level. J Clin Invest. 93:1994;50-55
7. Maiorana A., O'Driscoll G., Dembo L., et al. Effect of aerobic and resistance exercise training on vascular function in heart failure. Am J Physiol. 279:2000;H1999-2005
8. Maiorana A., O'Driscoll G., Cheetham C., et al. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol. 38:2001;860-866
9. Cole T.J., Bellizzi M.C., Flegal K.M., Deitz W.M. Establishing a standard definition for child overweight and obesity worldwide international survey. BMJ. 320:2000;1240-1243
10. Joannides R., Haefeli W.E., Linder L., et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 91:1995;1314-1319
11. Woodman R.J., Playford D.A., Watts G.F., et al. Improved analysis of brachial artery ultrasound images using a novel edge-detection software system. J Appl Physiol. 91:2001;929-937
12. Maiorana A., O'Driscoll G.J., Taylor R.R., Green D.J. Exercise and the nitric oxide vasodilator system. Sports Med. 33:2003;1013-1035
13. Hambrecht R., Wolf A., Geilen S., et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med. 342:2000;454-460
14. Green D.J., Walsh J.H., Maiorana A., Best M., Taylor R.R., O'Driscoll J.G. Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient population. Am J Physiol. 285:2003;H2679-2687
15. Neibauer J., Cooke J.P. Cardiovascular effects of exercise role of endothelial shear stress. J Am Coll Cardiol. 28:1996;1652-1660
16. Hambrecht R., Adams V., Erbs S., et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 107:2003;3152-3158
17. O'Driscoll J.G., Green D.J., Maiorana A., et al. Improvement in endothelial function by ACE inhibition in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 33:1999;1506-1511
18. O'Driscoll G., Green D., Taylor R. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation. 95:1997;1126-1131
19. Belardinelli R., Georgiou D., Cianci G., Purcaro A. Randomised, controlled trial of long-term moderate exercise training in chronic heart failure effects on functional capacity, quality of life, and clinical outcome. Circulation. 99:1999;1173-1182