Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents

Pediatrics

Volumn 131, Issue 2, 2013, Pages 364-382

  Copeland, Kenneth C ^a   Silverstein, Janet ^a   Moore, Kelly R ^a   Prazar, Greg E ^a   Raymer, Terry ^a   Shiffman, Richard N ^a   Springer, Shelley C ^a   Thaker, Vidhu V ^a   Anderson, Meaghan ^a   Spann, Stephen J ^a   Flinn, Susan K ^a  

^a NONE

Author keywords

Childhood; Clinical practice guidelines; Comanagement; Diabetes; Management; Treatment; Type 2 diabetes mellitus; Youth

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; LONG ACTING INSULIN; MEGLITINIDE; METFORMIN; NATEGLINIDE; ORAL ANTIDIABETIC AGENT; PIG INSULIN; REPAGLINIDE; ROSIGLITAZONE; SHORT ACTING INSULIN;

ABDOMINAL PAIN; ARTICLE; BLOATING; BLOOD GLUCOSE MONITORING; CHILD CARE; CHILD NUTRITION; CHILDHOOD OBESITY; CLINICAL DECISION MAKING; CLINICAL TRIAL (TOPIC); CONTROLLED DRUG RELEASE; CYANOCOBALAMIN DEFICIENCY; DIABETES EDUCATION; DIABETIC DIET; DIABETIC KETOACIDOSIS; DOSE RESPONSE; DRUG COST; DRUG DOSE INCREASE; DRUG TOLERABILITY; EVIDENCE BASED MEDICINE; FAMILY CENTERED CARE; GASTROINTESTINAL SYMPTOM; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEALTH CARE NEED; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; INTERDISCIPLINARY COMMUNICATION; KINESIOTHERAPY; LACTIC ACIDOSIS; LIFESTYLE MODIFICATION; LOOSE FECES; LOW DRUG DOSE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT COMPLIANCE; PATIENT COUNSELING; PRACTICE GUIDELINE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; SYSTEMATIC REVIEW; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; WEIGHT REDUCTION;

DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE;

EID: 84873479807     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-3494     Document Type: Article

References (82)

1. Centers for Disease Control and Prevention. Data and Statistics. Obesity rates among children in the United States. Available at: Www.cdc.gov/obesity/ childhood/prevalence. html. Accessed August 13, 2012
2. Copeland KC, Chalmers LJ, Brown RD. Type 2 diabetes in children: Oxymoron or medical metamorphosis? Pediatr Ann. 2005;34 (9):686-697
3. Narayan KM, Boyle JP, Thompson TJ, Sorensen SW, Williamson DF. Lifetime risk for diabetes mellitus in the United States. JAMA. 2003;290(14):1884-1890
4. Chopra M, Galbraith S, Darnton-Hill I. A global response to a global problem: The epidemic of overnutrition. Bull World Health Organ. 2002;80(12):952-958
5. Liese AD, D'Agostino RB, Jr, Hamman RF, et al SEARCH for Diabetes in Youth Study Group. The burden of diabetes mellitus among US youth: Prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics. 2006;118(4):1510-1518
6. Silverstein JH, Rosenbloom AL. Type 2 diabetes in children. Curr Diab Rep. 2001;1 (1):19-27
7. Pinhas-Hamiel O, Zeitler P. Clinical presentation and treatment of type 2 diabetes in children. Pediatr Diabetes. 2007;8(suppl 9):16-27
8. Dabelea D, Bell RA, D'Agostino RB Jr, et al Writing Group for the SEARCH for Diabetes in Youth Study Group. Incidence of diabetes in youth in the United States. JAMA. 2007; 297(24):2716-2724
9. Mayer-Davis EJ, Bell RA, Dabelea D, et al SEARCH for Diabetes in Youth Study Group. The many faces of diabetes in American youth: Type 1 and type 2 diabetes in five race and ethnic populations: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2009;32(suppl 2):S99-S101
10. Copeland KC, Zeitler P, Geffner M, et al TODAY Study Group. Characteristics of adolescents and youth with recent-onset type 2 diabetes: The TODAY cohort at baseline. J Clin Endocrinol Metab. 2011;96(1):159-167
11. Narayan KM, Williams R. Diabetes-a global problem needing global solutions. Prim Care Diabetes. 2009;3(1):3-4
12. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-1053
13. Silverstein J, Klingensmith G, Copeland K, et al American Diabetes Association. Care of children and adolescents with type 1 diabetes: A statement of the American Diabetes Association. Diabetes Care. 2005;28 (1):186-212
14. Pinhas-Hamiel O, Zeitler P. Barriers to the treatment of adolescent type 2 diabetes-a survey of provider perceptions. Pediatr Diabetes. 2003;4(1):24-28
15. Moore KR, McGowan MK, Donato KA, Kollipara S, Roubideaux Y. Community resources for promoting youth nutrition and physical activity. Am J Health Educ. 2009;40(5):298-303
16. Zeitler P, Epstein L, Grey M, et al The TODAY Study Group. Treatment Options for type 2 diabetes mellitus in Adolescents and Youth: A study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes mellitus. Pediatr Diabetes. 2007;8(2):74-87
17. Kane MP, Abu-Baker A, Busch RS. The utility of oral diabetes medications in type 2 diabetes of the young. Curr Diabetes Rev. 2005;1(1):83-92
18. De Berardis G, Pellegrini F, Franciosi M, et al. Quality of care and outcomes in type 2 diabetes patientes. Diabetes Care. 2004;27 (2):398-406
19. Ziemer DC, Miller CD, Rhee MK, et al. Clinical inertia contributes to poor diabetes control in a primary care setting. Diabetes Educ. 2005;31(4):564-571
20. Bradshaw B. The role of the family in managing therapy in minority children with type 2 diabetes mellitus. J Pediatr Endocrinol Metab. 2002;15(suppl 1):547-551
21. Pinhas-Hamiel O, Standiford D, Hamiel D, Dolan LM, Cohen R, Zeitler PS. The type 2 family: A setting for development and treatment of adolescent type 2 diabetes mellitus. Arch Pediatr Adolesc Med. 1999; 153(10):1063-1067
22. Mulvaney SA, Schlundt DG, Mudasiru E, et al. Parent perceptions of caring for adolescents with type 2 diabetes. Diabetes Care. 2006;29(5):993-997
23. Summerbell CD, Ashton V, Campbell KJ, Edmunds L, Kelly S, Waters E. Interventions for treating obesity in children. Cochrane Database Syst Rev. 2003;(3):CD001872
24. Skinner AC, Weinberger M, Mulvaney S, Schlundt D, Rothman RL. Accuracy of perceptions of overweight and relation to selfcare behaviors among adolescents with type 2 diabetes and their parents. Diabetes Care. 2008;31(2):227-229
25. American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care. 2000;23(3):381-389
26. Pinhas-Hamiel O, Zeitler P. Type 2 diabetes in adolescents, no longer rare. Pediatr Rev. 1998;19(12):434-435
27. Fagot-Campagna A, Pettitt DJ, Engelgau MM, et al. Type 2 diabetes among North American children and adolescents: An epidemiologic review and a public health perspective. J Pediatr. 2000;136(5):664-672
28. Rothman RL, Mulvaney S, Elasy TA, et al. Self-management behaviors, racial disparities, and glycemic control among adolescents with type 2 diabetes. Pediatrics. 2008;121(4). Available at: Www.pediatrics. org/cgi/content/full/ 121/4/e912
29. Scott CR, Smith JM, Cradock MM, Pihoker C. Characteristics of youth-onset noninsulindependent diabetes mellitus and insulindependent diabetes mellitus at diagnosis. Pediatrics. 1997;100(1):84-91
30. Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Changing prevalence of overweight children and adolescents at onset of insulin-treated diabetes. Diabetes Care. 2003;26(10):2871-2875
31. Springer SC, Copeland KC, Silverstein J, et al. Technical report: Management of type 2 diabetes mellitus in children and adolescents. Pediatrics. 2012, In press
32. American Academy of Pediatrics Steering Committee on Quality Improvement and Management. Classifying recommendations for clinical practice guidelines. Pediatrics. 2004;114(3):874-877
33. Shiffman RN, Dixon J, Brandt C, et al. The GuideLine Implementability Appraisal (GLIA): Development of an instrument to identify obstacles to guideline implementation. BMC Med Inform Decis Mak. 2005;5:23
34. Gungor N, Hannon T, Libman I, Bacha F, Arslanian S. Type 2 diabetes mellitus in youth: The complete picture to date. Pediatr Clin North Am. 2005;52(6):1579-1609
35. Daaboul JJ, Siverstein JH. The management of type 2 diabetes in children and adolescents. Minerva Pediatr. 2004;56(3):255-264
36. Kadmon PM, Grupposo PA. Glycemic control with metformin or insulin therapy in adolescents with type 2 diabetes mellitus. J Pediatr Endocrinol. 2004;17(9):1185-1193
37. Owada M, Nitadori Y, Kitagawa T. Treatment of NIDDM in youth. Clin Pediatr (Phila). 1998;37(2):117-121
38. Pinhas-Hamiel O, Zeitler P. Advances in epidemiology and treatment of type 2 diabetes in children. Adv Pediatr. 2005;52: 223-259
39. Jones KL, Haghi M. Type 2 diabetes mellitus in children and adolescence: A primer. Endocrinologist. 2000;10:389-396
40. Kawahara R, Amemiya T, Yoshino M, et al. Dropout of young non-insulin-dependent diabetics from diabetic care. Diabetes Res Clin Pract. 1994;24(3):181-185
41. Kaufman FR. Type 2 diabetes mellitus in children and youth: A new epidemic. J Pediatr Endocrinol Metab. 2002;15(suppl 2): 737-744
42. Garber AJ, Duncan TG, Goodman AM, Mills DJ, Rohlf JL. Efficacy of metformin in type II diabetes: Results of a double-blind, placebocontrolled, dose-response trial. Am J Med. 1997;103(6):491-497
43. Dabelea D, Pettitt DJ, Jones KL, Arslanian SA. Type 2 diabetes mellitus in minority children and adolescents: An emerging problem. Endocrinol Metabo Clin North Am. 1999;28(4):709-729
44. Miller JL, Silverstein JH. The management of type 2 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab. 2005;18(2):111-123
45. Reinehr T, Schober E, Roth CL, Wiegand S, Holl R; DPV-Wiss Study Group. Type 2 diabetes in children and adolescents in a 2-year follow-up: Insufficient adherence to diabetes centers. Horm Res. 2008;69(2):107-113
46. Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ. Type 2 diabetes in children and adolescents. Pediatr Diabetes. 2009;10(suppl 12):17-32
47. Zuhri-Yafi MI, Brosnan PG, Hardin DS. Treatment of type 2 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab. 2002;15(suppl 1):541-546
48. Rapaport R, Silverstein JH, Garzarella L, Rosenbloom AL. Type 1 and type 2 diabetes mellitus in childhood in the United States: Practice patterns by pediatric endocrinologists. J Pediatr Endocrinol Metab. 2004;17 (6):871-877
49. Glaser N, Jones KL. Non-insulin-dependent diabetes mellitus in children and adolescents. Adv Pediatr. 1996;43:359-396
50. Miller JL, Silverstein JH. The treatment of type 2 diabetes mellitus in youth: Which therapies? Treat Endocrinol. 2006;5(4):201-210
51. Silverstein JH, Rosenbloom AL. Treatment of type 2 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab. 2000;13(suppl 6):1403-1409
52. Dean H. Treatment of type 2 diabetes in youth: An argument for randomized controlled studies. Paediatr Child Health (Oxford). 1999;4(4):265-270
53. Sellers EAC, Dean HJ. Short-term insulin therapy in adolescents with type 2 diabetes mellitus. J Pediatr Endocrinol Metab. 2004; 17(11):1561-1564
54. Zeitler P, Hirst K, Pyle L, et al TODAY Study Group. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med. 2012;366(24):2247-2256
55. White NH, Cleary PA, Dahms W, Goldstein D, Malone J, Tamborlane WV; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group. Beneficial effects of intensive therapy of diabetes during adolescence: Outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT). J Pediatr. 2001;139(6):804-812
56. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977-986
57. Orchard TJ, Olson JC, Erbey JR, et al. Insulin resistance-related factors, but not glycemia, predict coronary artery disease in type 1 diabetes: 10-year follow-up data from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Care. 2003;26(5):1374-1379
58. UK Prospective Diabetes Study Group. U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: A progressive disease. Diabetes. 1995;44(11): 1249-1258
59. Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care. 2000;23 (suppl 2):B21-B29
60. Baynes JW, Bunn HF, Goldstein D, et al National Diabetes Data Group. National Diabetes Data Group: Report of the expert committee on glucosylated hemoglobin. Diabetes Care. 1984;7(6):602-606
61. Dabiri G, Jones K, Krebs J, et al. Benefits of rosiglitazone in children with type 2 diabetes mellitus [abstract]. Diabetes. 2005; A457
62. Ponder SW, Sullivan S, McBath G. Type 2 diabetes mellitus in teens. Diabetes Spectrum. 2000;13(2):95-119
63. Gahagan S, Silverstein J, and the American Academy of Pediatrics Committee on Native American Child Health. Prevention and treatment of type 2 diabetes mellitus in children, with special emphasis on American Indian and Alaska Native children. Pediatrics. 2003;112(4). Available at: Www.pediatrics.org/cgi/content/full/112/4/e328
64. Levine BS, Anderson BJ, Butler DA, Antisdel JE, Brackett J, Laffel LM. Predictors of glycemic control and short-term adverse outcomes in youth with type 1 diabetes. J Pediatr. 2001;139(2):197-203
65. Haller MJ, Stalvey MS, Silverstein JH. Predictors of control of diabetes: Monitoring may be the key. J Pediatr. 2004;144(5):660-661
66. Murata GH, Shah JH, Hoffman RM, et al Diabetes Outcomes in Veterans Study (DOVES). Intensified blood glucose monitoring improves glycemic control in stable, insulin-treated veterans with type 2 diabetes: The Diabetes Outcomes in Veterans Study (DOVES). Diabetes Care. 2003;26(6): 1759-1763
67. American Diabetes Association. Standards of medical care in diabetes-2011. Diabetes Care. 2011;34(suppl 1):S11-S61
68. Hanefeld M, Fischer S, Julius U, et al. Risk factors for myocardial infarction and death in newly detected NIDDM: The Diabetes Intervention Study, 11-year follow-up. Diabetologia. 1996;39(12):1577-1583
69. Franciosi M, Pellegrini F, De Berardis G, et al; QuED Study Group. The impact of blood glucose self-monitoring on metabolic control and quality of life in type 2 diabetic patients: An urgent need for better educational strategies. Diabetes Care. 2001;24 (11):1870-1877
70. American Dietetic Association. Recommendations summary: Pediatric weight management (PWM) using protein sparing modified fast diets for pediatric weight loss. Available at: Www.adaevidencelibrary. com/template.cfm?template=guide- summary&key=416. Accessed August 13, 2012
71. Knowler WC, Barrett-Connor E, Fowler SE, et al Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6): 393-403
72. Willi SM, Martin K, Datko FM, Brant BP. Treatment of type 2 diabetes in childhood using a very-low-calorie diet. Diabetes Care. 2004;27(2):348-353
73. Berry D, Urban A, Grey M. Management of type 2 diabetes in youth (part 2). J Pediatr Health Care. 2006;20(2):88-97
74. Loghmani ES. Nutrition therapy for overweight children and adolescents with type 2 diabetes. Curr Diab Rep. 2005;5(5):385-390
75. McGavock J, Sellers E, Dean H. Physical activity for the prevention and management of youth-onset type 2 diabetes mellitus: Focus on cardiovascular complications. Diab Vasc Dis Res. 2007;4(4):305-310
76. Centers for Disease Control and Prevention. Physical activity for everyone: How much physical activity do you need? Atlanta, GA: Centers for Disease Control and Prevention; 2008. Available at: Www. cdc.gov/ physicalactivity/everyone/guidelines/children.html. Accessed August 13, 2012
77. Pinhas-Hamiel O, Zeitler P. A weighty problem: Diagnosis and treatment of type 2 diabetes in adolescents. Diabetes Spectrum. 1997;10(4):292-298
78. Yamanouchi K, Shinozaki T, Chikada K, et al. Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care. 1995;18(6):775-778
79. National Heart, Lung, and Blood Institute, US Department of Health and Human Services, National Institutes of Health. Reduce screen time. Available at: Www.nhlbi. nih.gov/health/public/heart/obesity/wecan/reduce-screen-time/index. htm. Accessed August 13, 2012
80. Krebs NF, Jacobson MS; American Academy of Pediatrics Committee on Nutrition. Prevention of pediatric overweight and obesity. Pediatrics. 2003;112(2):424-430
81. American Academy of Pediatrics Committee on Public Education. American Academy of Pediatrics: Children, adolescents, and television. Pediatrics. 2001;107(2):423-426
82. American Medical Association. Appendix. Expert Committee recommendations on the assessment, prevention, and treatment of child and adolescent overweight and obesity. Chicago, IL: American Medical Association; January 25, 2007. Available at: Www. ama-assn.org/ama1/pub/upload/mm/433/ped-obesity-recs.pdf. Accessed August 13, 2012