메뉴 건너뛰기




Volumn 63, Issue 11, 2014, Pages 1189-1197

FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4+ T regulatory cells

Author keywords

CTLA4; FOXP3; Multiple myeloma; Therapy; Treg

Indexed keywords

BIOLOGICAL MARKER; CTLA4 PROTEIN, HUMAN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SYNDECAN 1;

EID: 84924920584     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1589-9     Document Type: Article
Times cited : (71)

References (37)
  • 1
    • 34547677725 scopus 로고    scopus 로고
    • Immunodeficiency and immunotherapy in multiple myeloma
    • PID: 17686051, COI: 1:CAS:528:DC%2BD2sXhtVKgsr7O
    • Pratt G, Goodyear O, Moss P (2007) Immunodeficiency and immunotherapy in multiple myeloma. Br J Haematol 138:563–579. doi:10.1111/j.1365-2141.2007.06705.x
    • (2007) Br J Haematol , vol.138 , pp. 563-579
    • Pratt, G.1    Goodyear, O.2    Moss, P.3
  • 3
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • PID: 15286781
    • O’Garra A, Vieira P (2004) Regulatory T cells and mechanisms of immune system control. Nat Med 10:801–805. doi:10.1038/nm0804-801
    • (2004) Nat Med , vol.10 , pp. 801-805
    • O’Garra, A.1    Vieira, P.2
  • 4
    • 84883681998 scopus 로고    scopus 로고
    • Natural and induced T regulatory cells in cancer
    • PID: 23874336, COI: 1:CAS:528:DC%2BC3sXht1ersL%2FO
    • Adeegbe DO, Nishikawa H (2013) Natural and induced T regulatory cells in cancer. Front Immunol 4:190. doi:10.3389/fimmu.2013.00190
    • (2013) Front Immunol , vol.4 , pp. 190
    • Adeegbe, D.O.1    Nishikawa, H.2
  • 6
    • 79958695591 scopus 로고    scopus 로고
    • Significantly reduced regulatory T cell population in patients with untreated multiple myeloma
    • PID: 21146215
    • Gupta R, Ganeshan P, Hakim M, Verma R, Sharma A (2011) Significantly reduced regulatory T cell population in patients with untreated multiple myeloma. Leuk Res 35:874–878. doi:10.1016/j.leukres.2010.11.010
    • (2011) Leuk Res , vol.35 , pp. 874-878
    • Gupta, R.1    Ganeshan, P.2    Hakim, M.3    Verma, R.4    Sharma, A.5
  • 7
    • 33646575622 scopus 로고    scopus 로고
    • In vivo peripheral expansion of naive CD4+ CD25high FoxP3+ regulatory T cells in patients with multiple myeloma
    • PID: 16410445, COI: 1:CAS:528:DC%2BD28XkvFWhu74%3D
    • Beyer M, Kochanek M, Giese T, Endl E, Weihrauch MR, Knolle PA, Classen S, Schultze JL (2006) In vivo peripheral expansion of naive CD4+ CD25high FoxP3+ regulatory T cells in patients with multiple myeloma. Blood 107:3940–3949. doi:10.1182/blood-2005-09-3671
    • (2006) Blood , vol.107 , pp. 3940-3949
    • Beyer, M.1    Kochanek, M.2    Giese, T.3    Endl, E.4    Weihrauch, M.R.5    Knolle, P.A.6    Classen, S.7    Schultze, J.L.8
  • 12
    • 84866309651 scopus 로고    scopus 로고
    • Runx1 and runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells
    • PID: 22984619, COI: 1:CAS:528:DC%2BC38Xhtl2jt7jF
    • Li L, Patsoukis N, Petkova V, Boussiotis VA (2012) Runx1 and runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells. PLoS ONE 7:e45115. doi:10.1371/journal.pone.0045115
    • (2012) PLoS ONE , vol.7 , pp. e45115
    • Li, L.1    Patsoukis, N.2    Petkova, V.3    Boussiotis, V.A.4
  • 13
    • 53449089919 scopus 로고    scopus 로고
    • Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
    • PID: 18669891, COI: 1:CAS:528:DC%2BD1cXht1SrtbzM
    • Dhodapkar KM, Barbuto S, Matthews P, Kukreja A, Mazumder A, Vesole D, Jagannath S, Dhodapkar MV (2008) Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 112:2878–2885. doi:10.1182/blood-2008-03-143222
    • (2008) Blood , vol.112 , pp. 2878-2885
    • Dhodapkar, K.M.1    Barbuto, S.2    Matthews, P.3    Kukreja, A.4    Mazumder, A.5    Vesole, D.6    Jagannath, S.7    Dhodapkar, M.V.8
  • 14
    • 0038509089 scopus 로고    scopus 로고
    • Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group
    • International Myeloma Working Group (2003) Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 121:749–757
    • (2003) Br J Haematol , vol.121 , pp. 749-757
    • International Myeloma Working Group1
  • 17
    • 3042785065 scopus 로고    scopus 로고
    • Expression of CTLA-4 (CD152) in peripheral blood T cells of children with influenza virus infection including encephalopathy in comparison with respiratory syncytial virus infection
    • PID: 15196256, COI: 1:CAS:528:DC%2BD2cXmsVShtb8%3D
    • Ayukawa H, Matsubara T, Kaneko M, Hasegawa M, Ichiyama T, Furukawa S (2004) Expression of CTLA-4 (CD152) in peripheral blood T cells of children with influenza virus infection including encephalopathy in comparison with respiratory syncytial virus infection. Clin Exp Immunol 137(1):151–155. doi:10.1111/j.1365-2249.2004.02502.x
    • (2004) Clin Exp Immunol , vol.137 , Issue.1 , pp. 151-155
    • Ayukawa, H.1    Matsubara, T.2    Kaneko, M.3    Hasegawa, M.4    Ichiyama, T.5    Furukawa, S.6
  • 20
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • PID: 11846609, COI: 1:CAS:528:DC%2BD38XhtFelt7s%3D
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408. doi:10.1006/meth.2001.1262
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 22
    • 33746599842 scopus 로고    scopus 로고
    • Regulatory T cells in cancer
    • PID: 16861339, COI: 1:CAS:528:DC%2BD28XnvFajtrs%3D
    • Beyer M, Schultze JL (2006) Regulatory T cells in cancer. Blood 108:804–811. doi:10.1182/blood-2006-02-002774
    • (2006) Blood , vol.108 , pp. 804-811
    • Beyer, M.1    Schultze, J.L.2
  • 23
    • 84872087150 scopus 로고    scopus 로고
    • Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry
    • Pessoa de Magalhães RJ, Vidriales MB, Paiva B, Fernandez-Gimenez C, García-Sanz R, Mateos MV, Gutierrez NC, Lecrevisse Q, Blanco JF, Hernández J, de las Heras N, Martinez-Lopez J, Roig M, Costa ES, Ocio EM, Perez-Andres M, Maiolino A, Nucci M, De La Rubia J, Lahuerta JJ, San-Miguel JF, Orfao A, Spanish Myeloma Group (GEM), Grupo Castellano-Leones de Gammapatias Monoclonales, cooperative study groups (2013) Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry. Haematologica 98:79–86. doi:10.3324/haematol.2012.067272
    • (2013) Haematologica , vol.98 , pp. 79-86
  • 24
    • 34047174849 scopus 로고    scopus 로고
    • Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    • PID: 17329235, COI: 1:CAS:528:DC%2BD2sXjsleku7Y%3D
    • Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, Bacchetta R, Roncarolo MG, Levings MK (2007) Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 19:345–354. doi:10.1093/intimm/dxm014
    • (2007) Int Immunol , vol.19 , pp. 345-354
    • Allan, S.E.1    Crome, S.Q.2    Crellin, N.K.3    Passerini, L.4    Steiner, T.S.5    Bacchetta, R.6    Roncarolo, M.G.7    Levings, M.K.8
  • 25
    • 78149419897 scopus 로고    scopus 로고
    • T regulatory cells in cord blood—FOXP3 demethylation as reliable quantitative marker
    • PID: 20967272
    • Liu J, Lluis A, Illi S, Layland L, Olek S, von Mutius E, Schaub B (2010) T regulatory cells in cord blood—FOXP3 demethylation as reliable quantitative marker. PLoS ONE 5:e13267. doi:10.1371/journal.pone.0013267
    • (2010) PLoS ONE , vol.5 , pp. e13267
    • Liu, J.1    Lluis, A.2    Illi, S.3    Layland, L.4    Olek, S.5    von Mutius, E.6    Schaub, B.7
  • 26
    • 84893765178 scopus 로고    scopus 로고
    • + T regulatory cells in anergic lepromatous leprosy patients
    • PID: 24454972
    • + T regulatory cells in anergic lepromatous leprosy patients. PLoS Negl Trop Dis 8:e2639. doi:10.1371/journal.pntd.0002639
    • (2014) PLoS Negl Trop Dis , vol.8 , pp. e2639
    • Saini, C.1    Ramesh, V.2    Nath, I.3
  • 28
    • 43449112388 scopus 로고    scopus 로고
    • Confirmation of the utility of the international staging system and identification of a unique pattern of disease in Brazilian patients with multiple myeloma
    • HungriaVT, Maiolino A, Martinez G, Colleoni GW, Coelho EO, Rocha L, Nunes R, Bittencourt R, Oliveira LC, Faria RM, Pasquini R, Magalhães SM, Souza CA, Pinto Neto JV, Barreto L, Andrade E, Portella MS, Bolejack V, Durie BG, International Myeloma Working Group Latin America (2008) Confirmation of the utility of the international staging system and identification of a unique pattern of disease in Brazilian patients with multiple myeloma. Haematologica 93(5):791–792. doi:10.3324/haematol.11637
    • (2008) Haematologica , vol.93 , Issue.5 , pp. 791-792
  • 29
    • 84856423569 scopus 로고    scopus 로고
    • The frequency of T regulatory cells modulates the survival of multiple myeloma patients: detailed characterisation of immune status in multiple myeloma
    • PID: 22223085, COI: 1:CAS:528:DC%2BC38XhslGgu74%3D
    • Giannopoulos K, Kaminska W, Hus I, Dmoszynska A (2012) The frequency of T regulatory cells modulates the survival of multiple myeloma patients: detailed characterisation of immune status in multiple myeloma. Br J Cancer 106:546–552. doi:10.1038/bjc.2011.575
    • (2012) Br J Cancer , vol.106 , pp. 546-552
    • Giannopoulos, K.1    Kaminska, W.2    Hus, I.3    Dmoszynska, A.4
  • 30
    • 84867372743 scopus 로고    scopus 로고
    • Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma
    • Raja KRM, Rihova L, Zahradova L, Klincova M, Penka M, Hajek R (2012) Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma. PLoS ONE 7(10):e47077. doi:10.1371/journal.pone.004707
    • (2012) PLoS ONE , vol.7 , Issue.10 , pp. e47077
    • Raja, K.R.M.1    Rihova, L.2    Zahradova, L.3    Klincova, M.4    Penka, M.5    Hajek, R.6
  • 31
    • 77955938173 scopus 로고    scopus 로고
    • Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer
    • PID: 20550524, COI: 1:CAS:528:DC%2BC3cXhtFylu7jE
    • Maruyama T, Kono K, Mizukami Y, Kawaguchi Y, Mimura K, Watanabe M, Izawa S, Fujii H (2010) Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer. Cancer Sci 101:1947–1954. doi:10.1111/j.1349-7006.2010.01624.x
    • (2010) Cancer Sci , vol.101 , pp. 1947-1954
    • Maruyama, T.1    Kono, K.2    Mizukami, Y.3    Kawaguchi, Y.4    Mimura, K.5    Watanabe, M.6    Izawa, S.7    Fujii, H.8
  • 32
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+ CD25− naïve T cells to CD4+ CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
    • PID: 14676299, COI: 1:CAS:528:DC%2BD3sXpvFaktLg%3D
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+ CD25− naïve T cells to CD4+ CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 198:1875–8186. doi:10.1084/jem.20030152
    • (2003) J Exp Med , vol.198 , pp. 1875-8186
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 33
    • 29244435493 scopus 로고    scopus 로고
    • Inducing and expanding regulatory T cell populations by foreign antigen
    • PID: 16244650, COI: 1:CAS:528:DC%2BD2MXhtlShur3J
    • Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H (2005) Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 6:1219–1227. doi:10.1038/ni1265
    • (2005) Nat Immunol , vol.6 , pp. 1219-1227
    • Kretschmer, K.1    Apostolou, I.2    Hawiger, D.3    Khazaie, K.4    Nussenzweig, M.C.5    von Boehmer, H.6
  • 35
    • 61949463911 scopus 로고    scopus 로고
    • IL-17 and Th17 Cells
    • PID: 19132915, COI: 1:CAS:528:DC%2BD1MXlsFSltrY%3D
    • Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27:485–517. doi:10.1146/annurev.immunol.021908.132710
    • (2009) Annu Rev Immunol , vol.27 , pp. 485-517
    • Korn, T.1    Bettelli, E.2    Oukka, M.3    Kuchroo, V.K.4
  • 36
    • 84875160155 scopus 로고    scopus 로고
    • Human regulatory T cells do not suppress the antitumor immunity in the bone marrow: a role for bone marrow stromal cells in neutralizing regulatory T cells
    • PID: 23382115, COI: 1:CAS:528:DC%2BC3sXktFKkt7w%3D
    • Guichelaar T, Emmelot ME, Rozemuller H, Martini B, Groen RW, Storm G, Lokhorst HM, Martens AC, Mutis T (2013) Human regulatory T cells do not suppress the antitumor immunity in the bone marrow: a role for bone marrow stromal cells in neutralizing regulatory T cells. Clin Cancer Res 19:1467–1475. doi:10.1158/1078-0432.CCR-12-2177
    • (2013) Clin Cancer Res , vol.19 , pp. 1467-1475
    • Guichelaar, T.1    Emmelot, M.E.2    Rozemuller, H.3    Martini, B.4    Groen, R.W.5    Storm, G.6    Lokhorst, H.M.7    Martens, A.C.8    Mutis, T.9
  • 37
    • 67650351923 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase controls conversion of Foxp3 Tregs to TH17-like cells in tumor-draining lymph nodes
    • PID: 19366986, COI: 1:CAS:528:DC%2BD1MXnslSmurc%3D
    • Sharma MD, Hou DY, Liu Y, Koni PA, Metz R, Chandler P, Mellor AL, He Y, Munn DH (2009) Indoleamine 2,3-dioxygenase controls conversion of Foxp3 Tregs to TH17-like cells in tumor-draining lymph nodes. Blood 113:6102–6111. doi:10.1182/blood-2008-12-195354
    • (2009) Blood , vol.113 , pp. 6102-6111
    • Sharma, M.D.1    Hou, D.Y.2    Liu, Y.3    Koni, P.A.4    Metz, R.5    Chandler, P.6    Mellor, A.L.7    He, Y.8    Munn, D.H.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.