The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release

Journal of Biological Chemistry

Volumn 290, Issue 11, 2015, Pages 7304-7313

  Hedgepeth, Serena C ^a,b   Garcia, M Iveth ^a,b   Wagner, Larry E ^d   Rodriguez, Ana M ^c   Chintapalli, Sree V ^e   Snyder, Russell R ^c   Hankins, Gary D V ^c   Henderson, Beric R ^f   Brodie, Kirsty M ^f   Yule, David I ^d   Van Rossum, Damian B ^e   Boehning, Darren ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

^f UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CALCIUM; CELL DEATH; CELL MEMBRANES; ONCOGENIC VIRUSES; POLYOLS; PROTEINS; SUGARS;

CALCIUM CHANNELS; CALCIUM RELEASE; ENDOPLASMIC RETICULUM; LIPID BINDING; PROTEIN-PROTEIN INTERACTIONS; PROTO-ONCOGENES; SIGNALING PATHWAYS; TUMOR SUPPRESSORS;

TUMORS;

BRCA1 PROTEIN; CASPASE 3; CYTOCHROME C; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; CALCIUM;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RING FINGER MOTIF; UPREGULATION; CALCIUM SIGNALING; CHEMICAL STRUCTURE; HUMAN; METABOLISM; NEOPLASM; TUMOR CELL LINE;

APOPTOSIS; BRCA1 PROTEIN; CALCIUM; CALCIUM SIGNALING; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MODELS, MOLECULAR; NEOPLASMS;

EID: 84924897990     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.611186     Document Type: Article

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