A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Mothe, Beatriz ^a,b   Hu, Xintao ^c   Llano, Anuska ^a   Rosati, Margherita ^c   Olvera, Alex ^a   Kulkarni, Viraj ^c   Valentin, Antonio ^c   Alicea, Candido ^c   Pilkington, Guy R ^c   Sardesai, Niranjan Y ^d   Rocafort, Muntsa ^a   Crespo, Manel ^e   Carrillo, Jorge ^a   Marco, Andrés ^f   Mullins, James I ^g   Dorrell, Lucy ^h   Hanke, Tomáš ⁱ   Clotet, Bonaventura ^a,b,j   Pavlakis, George N ^c   Felber, Barbara K ^c   Brander, Christian ^a,b,j,k   more..

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b UNIVERSITY OF VIC CENTRAL UNIVERSITY OF CATALONIA   (Spain)

^c NATIONAL CANCER INSTITUTE   (United States)

^d Inovio Pharmaceuticals Inc   (United States)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f Centres Penitenciaris BCN   (Spain)

^g UNIVERSITY OF WASHINGTON   (United States)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

^j UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^k INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

more..

Author keywords

CTL escape; HIV 1 specific CTL; HIV 1T cell immunogen; HLA; Immunogenicity; Population coverage; Subdominant; T helper epitope; Viral fitness

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; EPITOPE; GAG PROTEIN; GAMMA INTERFERON; GRANZYME B; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NEF PROTEIN; PLASMID DNA; POL PROTEIN; VIF PROTEIN; VIRUS VECTOR; ANTIVIRUS AGENT; PEPTIDE;

ADULT; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CD107A+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FRACTIONATION; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DEGRANULATION; EFFECTOR CELL; FEMALE; GAMMA INTERFERON+ CD8+ T LYMPHOCYTE; GENE EXPRESSION; GRANZYME B+ T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE B; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE C; IMMUNOGENICITY; INFECTION CONTROL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN DETERMINATION; RHESUS MONKEY; SINGLE DRUG DOSE; T LYMPHOCYTE; VACCINATION; VIRUS LOAD; VIRUS MUTATION; VIRUS REPLICATION; ALLELE; ANIMAL; C57BL MOUSE; CHEMISTRY; COHORT ANALYSIS; CYTOTOXIC T LYMPHOCYTE; GENETICS; HAPLOTYPE; HEK293 CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MALE; VIROLOGY;

AIDS VACCINES; ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; EPITOPES; EPITOPES, T-LYMPHOCYTE; FEMALE; HAPLOTYPES; HEK293 CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOLOGIC MEMORY; MACACA MULATTA; MALE; MICE, INBRED C57BL; PEPTIDES; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION;

EID: 84924860552     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0392-5     Document Type: Article

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