-
1
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225-49.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008; 26: 3543-51.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
Von Pawel, J.3
-
3
-
-
84879991975
-
A randomized phase II study of pemetrexed in combination with cisplatin or carboplatin as first-line therapy for patients with locally advanced or metastatic non-small-cell lung cancer
-
Schuette WH, Groschel A, Sebastian M, et al. A randomized phase II study of pemetrexed in combination with cisplatin or carboplatin as first-line therapy for patients with locally advanced or metastatic non-small-cell lung cancer. Clin Lung Cancer 2013; 14: 215-23.
-
(2013)
Clin Lung Cancer
, vol.14
, pp. 215-223
-
-
Schuette, W.H.1
Groschel, A.2
Sebastian, M.3
-
4
-
-
1342268525
-
American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003
-
Pfister DG, Johnson DH, Azzoli CG, et al. American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol 2004; 22: 330-53.
-
(2004)
J Clin Oncol
, vol.22
, pp. 330-353
-
-
Pfister, D.G.1
Johnson, D.H.2
Azzoli, C.G.3
-
5
-
-
0028905076
-
Transcription factor ATF2 regulation by the JNK signal transduction pathway
-
Gupta S, Campbell D, Derijard B, et al. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 1995; 267: 389-93.
-
(1995)
Science
, vol.267
, pp. 389-393
-
-
Gupta, S.1
Campbell, D.2
Derijard, B.3
-
6
-
-
0029034251
-
ATF-2 contains a phosphorylation-dependent transcriptional activation domain
-
Livingstone C, Patel G, Jones N,. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J 1995; 14: 1785-97.
-
(1995)
EMBO J
, vol.14
, pp. 1785-1797
-
-
Livingstone, C.1
Patel, G.2
Jones, N.3
-
8
-
-
0038757747
-
The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair
-
Hayakawa J, Depatie C, Ohmichi M, et al. The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J Biol Chem 2003; 278: 20582-92.
-
(2003)
J Biol Chem
, vol.278
, pp. 20582-20592
-
-
Hayakawa, J.1
Depatie, C.2
Ohmichi, M.3
-
9
-
-
0035971496
-
Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis
-
van Dam H, Castellazzi M,. Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis. Oncogene 2001; 20: 2453-64.
-
(2001)
Oncogene
, vol.20
, pp. 2453-2464
-
-
Van Dam, H.1
Castellazzi, M.2
-
10
-
-
0346365379
-
Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival
-
Berger AJ, Kluger HM, Li N, et al. Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. Cancer Res 2003; 63: 8103-7.
-
(2003)
Cancer Res
, vol.63
, pp. 8103-8107
-
-
Berger, A.J.1
Kluger, H.M.2
Li, N.3
-
11
-
-
0036065039
-
Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study
-
Tao X, Younger J, Fan FZ, et al. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthritis Rheum 2002; 46: 1735-43.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1735-1743
-
-
Tao, X.1
Younger, J.2
Fan, F.Z.3
-
12
-
-
65549142792
-
Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model
-
Kim DY, Park JW, Jeoung D, et al. Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model. Eur J Pharmacol 2009; 612: 98-105.
-
(2009)
Eur J Pharmacol
, vol.612
, pp. 98-105
-
-
Kim, D.Y.1
Park, J.W.2
Jeoung, D.3
-
13
-
-
0042662901
-
Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook
-
Qiu D, Kao PN,. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D 2003; 4: 1-18.
-
(2003)
Drugs R D
, vol.4
, pp. 1-18
-
-
Qiu, D.1
Kao, P.N.2
-
14
-
-
2842616065
-
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol
-
Nagase M, Oto J, Sugiyama S, et al. Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci Biotechnol Biochem 2003; 67: 1883-7.
-
(2003)
Biosci Biotechnol Biochem
, vol.67
, pp. 1883-1887
-
-
Nagase, M.1
Oto, J.2
Sugiyama, S.3
-
15
-
-
36749077060
-
Preclinical studies of celastrol and acetyl isogambogic acid in melanoma
-
Abbas S, Bhoumik A, Dahl R, et al. Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin Cancer Res 2007; 13: 6769-78.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6769-6778
-
-
Abbas, S.1
Bhoumik, A.2
Dahl, R.3
-
16
-
-
38349153572
-
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
-
Zhang T, Hamza A, Cao X, et al. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther 2008; 7: 162-70.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 162-170
-
-
Zhang, T.1
Hamza, A.2
Cao, X.3
-
17
-
-
77949454738
-
Celastrol causes apoptosis and cell cycle arrest in rat glioma cells
-
Ge P, Ji X, Ding Y, et al. Celastrol causes apoptosis and cell cycle arrest in rat glioma cells. Neurol Res 2010; 32: 94-100.
-
(2010)
Neurol Res
, vol.32
, pp. 94-100
-
-
Ge, P.1
Ji, X.2
Ding, Y.3
-
18
-
-
77649178833
-
Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
-
Lu Z, Jin Y, Qiu L, et al. Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation. Cancer Lett 2010; 290: 182-91.
-
(2010)
Cancer Lett
, vol.290
, pp. 182-191
-
-
Lu, Z.1
Jin, Y.2
Qiu, L.3
-
19
-
-
79957961355
-
Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways
-
Mou H, Zheng Y, Zhao P, et al. Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways. Toxicology In Vitro 2011; 25: 1027-32.
-
(2011)
Toxicology in Vitro
, vol.25
, pp. 1027-1032
-
-
Mou, H.1
Zheng, Y.2
Zhao, P.3
-
20
-
-
42649088411
-
Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
-
Huang Y, Zhou Y, Fan Y, et al. Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett. 2008; 264: 101-6.
-
(2008)
Cancer Lett.
, vol.264
, pp. 101-106
-
-
Huang, Y.1
Zhou, Y.2
Fan, Y.3
-
21
-
-
33646406554
-
Celastrol, a triterpene extracted from the Chinese "thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
-
Yang H, Chen D, Cui QC, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 2006; 66: 4758-65.
-
(2006)
Cancer Res
, vol.66
, pp. 4758-4765
-
-
Yang, H.1
Chen, D.2
Cui, Q.C.3
-
22
-
-
70449412700
-
The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma
-
He D, Xu Q, Yan M, et al. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. BMC Cancer 2009; 9: 343.
-
(2009)
BMC Cancer
, vol.9
, pp. 343
-
-
He, D.1
Xu, Q.2
Yan, M.3
-
23
-
-
72449169529
-
Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol
-
Zhu H, Ding WJ, Wu R, et al. Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol. Cancer Invest 2010; 28: 23-32.
-
(2010)
Cancer Invest
, vol.28
, pp. 23-32
-
-
Zhu, H.1
Ding, W.J.2
Wu, R.3
-
24
-
-
67649525966
-
Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer
-
Dai Y, DeSano JT, Meng Y, et al. Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer. Int J Radiat Oncol Biol Phys 2009; 74: 1217-25.
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.74
, pp. 1217-1225
-
-
Dai, Y.1
Desano, J.T.2
Meng, Y.3
-
25
-
-
38049121045
-
Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells
-
Jung HW, Chung YS, Kim YS, et al. Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells. Exp Mol Med 2007; 39: 715-21.
-
(2007)
Exp Mol Med
, vol.39
, pp. 715-721
-
-
Jung, H.W.1
Chung, Y.S.2
Kim, Y.S.3
-
26
-
-
70349554345
-
Antiangiogenic effect of celastrol on the growth of human glioma: An in vitro and in vivo study
-
Zhou YX, Huang YL,. Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study. Chin Med J 2009; 122: 1666-73.
-
(2009)
Chin Med J
, vol.122
, pp. 1666-1673
-
-
Zhou, Y.X.1
Huang, Y.L.2
-
27
-
-
0037424425
-
Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction
-
Bai JP, Shi YL, Fang X, et al. Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. Eur J Pharmacol 2003; 464: 9-15.
-
(2003)
Eur J Pharmacol
, vol.464
, pp. 9-15
-
-
Bai, J.P.1
Shi, Y.L.2
Fang, X.3
-
28
-
-
33646851612
-
Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking
-
Sun HY, Liu XD, Xiong QJ, et al. Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking. J Biol Chem 2006; 281: 5877-84.
-
(2006)
J Biol Chem
, vol.281
, pp. 5877-5884
-
-
Sun, H.Y.1
Liu, X.D.2
Xiong, Q.J.3
-
29
-
-
78751506175
-
Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
-
Raja SM, Clubb RJ, Ortega-Cava C, et al. Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers. Cancer Biol Ther 2011; 11: 263-76.
-
(2011)
Cancer Biol Ther
, vol.11
, pp. 263-276
-
-
Raja, S.M.1
Clubb, R.J.2
Ortega-Cava, C.3
-
30
-
-
65449116159
-
Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis
-
Yuan Z, Gong S, Luo J, et al. Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Mol Cell Biol 2009; 29: 2431-42.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2431-2442
-
-
Yuan, Z.1
Gong, S.2
Luo, J.3
-
31
-
-
16244371591
-
-
Lyon: IARC Press.
-
Travis WD, Brambilla E, Müller-Hermelink HK, et al. World Health Organization classification of tumors: pathology and genetics of tumors of the lung, pleura, thymus and hearted. Lyon: IARC Press, 2004.
-
(2004)
World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Hearted
-
-
Travis, W.D.1
Brambilla, E.2
Müller-Hermelink, H.K.3
-
32
-
-
0032562781
-
Inhibition of the expression of mitogen-activated protein phosphatase-1 potentiates apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells
-
Guo YL, Kang B, Williamson JR,. Inhibition of the expression of mitogen-activated protein phosphatase-1 potentiates apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells. J Biol Chem 1998; 273: 10362-6.
-
(1998)
J Biol Chem
, vol.273
, pp. 10362-10366
-
-
Guo, Y.L.1
Kang, B.2
Williamson, J.R.3
-
33
-
-
0032576820
-
ATF2 confers radiation resistance to human melanoma cells
-
Ronai Z, Yang YM, Fuchs SY, et al. ATF2 confers radiation resistance to human melanoma cells. Oncogene 1998; 16: 523-31.
-
(1998)
Oncogene
, vol.16
, pp. 523-531
-
-
Ronai, Z.1
Yang, Y.M.2
Fuchs, S.Y.3
-
34
-
-
0036735367
-
An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis
-
Bhoumik A, Huang TG, Ivanov V, et al. An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis. J Clin Invest 2002; 110: 643-50.
-
(2002)
J Clin Invest
, vol.110
, pp. 643-650
-
-
Bhoumik, A.1
Huang, T.G.2
Ivanov, V.3
-
35
-
-
78650695527
-
A role for ATF2 in regulating MITF and melanoma development
-
Shah M, Bhoumik A, Goel V, et al. A role for ATF2 in regulating MITF and melanoma development. PLoS Genet 2010; 6: e1001258.
-
(2010)
PLoS Genet
, vol.6
, pp. e1001258
-
-
Shah, M.1
Bhoumik, A.2
Goel, V.3
-
36
-
-
8844285956
-
Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress
-
Hayakawa J, Mittal S, Wang Y, et al. Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Mol Cell 2004; 16: 521-35.
-
(2004)
Mol Cell
, vol.16
, pp. 521-535
-
-
Hayakawa, J.1
Mittal, S.2
Wang, Y.3
-
37
-
-
34547164540
-
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
-
Johnson GL, Nakamura K,. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta 2007; 1773: 1341-8.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1341-1348
-
-
Johnson, G.L.1
Nakamura, K.2
-
38
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis JM, Avruch J,. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001; 81: 807-69.
-
(2001)
Physiol Rev
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
39
-
-
0030920914
-
The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
-
Potapova O, Haghighi A, Bost F, et al. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J Biol Chem 1997; 272: 14041-4.
-
(1997)
J Biol Chem
, vol.272
, pp. 14041-14044
-
-
Potapova, O.1
Haghighi, A.2
Bost, F.3
-
40
-
-
8544259596
-
Inhibition of melanoma growth and metastasis by ATF2-derived peptides
-
Bhoumik A, Gangi L, Ronai Z,. Inhibition of melanoma growth and metastasis by ATF2-derived peptides. Cancer Res 2004; 64: 8222-30.
-
(2004)
Cancer Res
, vol.64
, pp. 8222-8230
-
-
Bhoumik, A.1
Gangi, L.2
Ronai, Z.3
-
41
-
-
77954889411
-
Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL
-
Salameh A, Galvagni F, Anselmi F, et al. Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL. J Biol Chem 2010; 285: 23096-104.
-
(2010)
J Biol Chem
, vol.285
, pp. 23096-23104
-
-
Salameh, A.1
Galvagni, F.2
Anselmi, F.3
-
42
-
-
65949124261
-
Non-small cell lung cancer exhibits transcript overexpression of genes associated with homologous recombination and DNA replication pathways
-
Saviozzi S, Ceppi P, Novello S, et al. Non-small cell lung cancer exhibits transcript overexpression of genes associated with homologous recombination and DNA replication pathways. Cancer Res 2009; 69: 3390-6.
-
(2009)
Cancer Res
, vol.69
, pp. 3390-3396
-
-
Saviozzi, S.1
Ceppi, P.2
Novello, S.3
-
43
-
-
61349137712
-
Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy
-
Ceppi P, Novello S, Cambieri A, et al. Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res 2009; 15: 1039-45.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1039-1045
-
-
Ceppi, P.1
Novello, S.2
Cambieri, A.3
-
44
-
-
79959646086
-
Aurora kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation
-
Lo Iacono M, Monica V, Saviozzi S, et al. Aurora kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. J Transl Med 2011; 9: 100.
-
(2011)
J Transl Med
, vol.9
, pp. 100
-
-
Lo Iacono, M.1
Monica, V.2
Saviozzi, S.3
-
45
-
-
62849118494
-
Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation
-
Mortaz E, Kraneveld AD, Smit JJ, et al. Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation. PLoS ONE 2009; 4: e4946.
-
(2009)
PLoS ONE
, vol.4
, pp. e4946
-
-
Mortaz, E.1
Kraneveld, A.D.2
Smit, J.J.3
-
46
-
-
0036853764
-
Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells
-
Ranganna K, Yousefipour Z, Nasif R, et al. Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells. Mol Cell Biochem 2002; 240: 83-98.
-
(2002)
Mol Cell Biochem
, vol.240
, pp. 83-98
-
-
Ranganna, K.1
Yousefipour, Z.2
Nasif, R.3
-
47
-
-
67449084386
-
Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries
-
Vikman P, Xu CB, Edvinsson L,. Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. Vasc Health Risk Manag 2009; 5: 333-41.
-
(2009)
Vasc Health Risk Manag
, vol.5
, pp. 333-341
-
-
Vikman, P.1
Xu, C.B.2
Edvinsson, L.3
-
48
-
-
0032014073
-
DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
-
Kasibhatla S, Brunner T, Genestier L, et al. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Mol Cell 1998; 1: 543-51.
-
(1998)
Mol Cell
, vol.1
, pp. 543-551
-
-
Kasibhatla, S.1
Brunner, T.2
Genestier, L.3
-
49
-
-
0032570594
-
Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
-
Wang TH, Wang HS, Ichijo H, et al. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J Biol Chem 1998; 273: 4928-36.
-
(1998)
J Biol Chem
, vol.273
, pp. 4928-4936
-
-
Wang, T.H.1
Wang, H.S.2
Ichijo, H.3
|