-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-1310
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
-
2
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-150
-
(2003)
N Engl J Med
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
3
-
-
11344279695
-
Bench-to-bedside review: Sepsis is a disease of the microcirculation
-
Spronk PE, Zandstra DF, Ince C: Bench-to-bedside review: Sepsis is a disease of the microcirculation. Crit Care 2004;8:462-468
-
(2004)
Crit Care
, vol.8
, pp. 462-468
-
-
Spronk, P.E.1
Zandstra, D.F.2
Ince, C.3
-
5
-
-
84860240248
-
Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock
-
Edul VS, Enrico C, Laviolle B, et al: Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. Crit Care Med 2012;40:1443-1448
-
(2012)
Crit Care Med
, vol.40
, pp. 1443-1448
-
-
Edul, V.S.1
Enrico, C.2
Laviolle, B.3
-
6
-
-
33845872563
-
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: Relationship to hemodynamics, oxygen transport, and survival
-
98.e1-98.e2
-
Trzeciak S, Dellinger RP, Parrillo JE, et al; Microcirculatory Alterations in Resuscitation and Shock Investigators: Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: Relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007;49:88-98, 98.e1-98.e2
-
(2007)
Ann Emerg Med
, vol.49
, pp. 88-98
-
-
Trzeciak, S.1
Dellinger, R.P.2
Parrillo, J.E.3
-
7
-
-
84886650526
-
Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients
-
Hernandez G, Boerma EC, Dubin A, et al: Severe abnormalities in microvascular perfused vessel density are associated to organ dysfunctions and mortality and can be predicted by hyperlactatemia and norepinephrine requirements in septic shock patients. J Crit Care 2013;28:538.e9-538.e14
-
(2013)
J Crit Care
, vol.28
, pp. 538e9-538e14
-
-
Hernandez, G.1
Boerma, E.C.2
Dubin, A.3
-
8
-
-
62749206780
-
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
-
Trzeciak S, McCoy JV, Phillip Dellinger R, et al; Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators: Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008;34:2210-2217
-
(2008)
Intensive Care Med
, vol.34
, pp. 2210-2217
-
-
Trzeciak, S.1
McCoy, J.V.2
Phillip Dellinger, R.3
-
9
-
-
44049093984
-
Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
-
Trzeciak S, Cinel I, Dellinger RP, et al; Microcirculatory Alterations in Resuscitation and Shock (MARS) Investigators: Resuscitating the microcirculation in sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008;15:399-413
-
(2008)
Acad Emerg Med
, vol.15
, pp. 399-413
-
-
Trzeciak, S.1
Cinel, I.2
Dellinger, R.P.3
-
10
-
-
0037010370
-
Nitroglycerin in septic shock after intravascular volume resuscitation
-
Spronk PE, Ince C, Gardien MJ, et al: Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002;360:1395-1396
-
(2002)
Lancet
, vol.360
, pp. 1395-1396
-
-
Spronk, P.E.1
Ince, C.2
Gardien, M.J.3
-
11
-
-
58149229193
-
Nitric oxide donors in sepsis: A systematic review of clinical and in vivo preclinical data
-
Lamontagne F, Meade M, Ondiveeran HK, et al: Nitric oxide donors in sepsis: A systematic review of clinical and in vivo preclinical data. Shock 2008;30:653-659
-
(2008)
Shock
, vol.30
, pp. 653-659
-
-
Lamontagne, F.1
Meade, M.2
Ondiveeran, H.K.3
-
12
-
-
0034954199
-
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery
-
Cannon RO III, Schechter AN, Panza JA, et al: Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J Clin Invest 2001;108:279-287
-
(2001)
J Clin Invest
, vol.108
, pp. 279-287
-
-
Cannon, R.O.1
Schechter, A.N.2
Panza, J.A.3
-
13
-
-
0032102218
-
Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds
-
Fox-Robichaud A, Payne D, Hasan SU, et al: Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J Clin Invest 1998;101:2497-2505
-
(1998)
J Clin Invest
, vol.101
, pp. 2497-2505
-
-
Fox-Robichaud, A.1
Payne, D.2
Hasan, S.U.3
-
14
-
-
10744231572
-
Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation
-
Gianetti J, Del Sarto P, Bevilacqua S, et al: Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation. J Thorac Cardiovasc Surg 2004;127:44-50
-
(2004)
J Thorac Cardiovasc Surg
, vol.127
, pp. 44-50
-
-
Gianetti, J.1
Del Sarto, P.2
Bevilacqua, S.3
-
15
-
-
34848888949
-
Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
-
Lang JD Jr, Teng X, Chumley P, et al: Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation. J Clin Invest 2007;117:2583-2591
-
(2007)
J Clin Invest
, vol.117
, pp. 2583-2591
-
-
Lang, J.D.1
Teng, X.2
Chumley, P.3
-
16
-
-
33846571344
-
Inhaled nitric oxide attenuates reperfusion inflammatory responses in humans
-
Mathru M, Huda R, Solanki DR, et al: Inhaled nitric oxide attenuates reperfusion inflammatory responses in humans. Anesthesiology 2007;106:275-282
-
(2007)
Anesthesiology
, vol.106
, pp. 275-282
-
-
Mathru, M.1
Huda, R.2
Solanki, D.R.3
-
17
-
-
1542283693
-
Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion
-
Ng ES, Jourd'heuil D, McCord JM, et al: Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion. Circ Res 2004;94:559-565
-
(2004)
Circ Res
, vol.94
, pp. 559-565
-
-
Ng, E.S.1
Jourd'heuil, D.2
McCord, J.M.3
-
18
-
-
0034633659
-
Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
-
Gladwin MT, Shelhamer JH, Schechter AN, et al: Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proc Natl Acad Sci U S A 2000;97:11482-11487
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 11482-11487
-
-
Gladwin, M.T.1
Shelhamer, J.H.2
Schechter, A.N.3
-
19
-
-
77249162677
-
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: A randomized clinical trial
-
Jones AE, Shapiro NI, Trzeciak S, et al; Emergency Medicine Shock Research Network (EMShockNet) Investigators: Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: A randomized clinical trial. JAMA 2010;303:739-746
-
(2010)
JAMA
, vol.303
, pp. 739-746
-
-
Jones, A.E.1
Shapiro, N.I.2
Trzeciak, S.3
-
20
-
-
0035829842
-
Early goal-directed therapy in the treatment of severe sepsis and septic shock
-
Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-1377
-
(2001)
N Engl J Med
, vol.345
, pp. 1368-1377
-
-
Rivers, E.1
Nguyen, B.2
Havstad, S.3
-
21
-
-
0031052369
-
Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure
-
Neonatal Inhaled Nitric Oxide Study Group: Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997;336:597-604
-
(1997)
N Engl J Med
, vol.336
, pp. 597-604
-
-
-
22
-
-
33746452905
-
Inhaled nitric oxide in preterm infants undergoing mechanical ventilation
-
Ballard RA, Truog WE, Cnaan A, et al; NO CLD Study Group: Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med 2006;355:343-353
-
(2006)
N Engl J Med
, vol.355
, pp. 343-353
-
-
Ballard, R.A.1
Truog, W.E.2
Cnaan, A.3
-
23
-
-
0034677445
-
Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group
-
Clark RH, Kueser TJ, Walker MW, et al: Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med 2000;342:469-474
-
(2000)
N Engl J Med
, vol.342
, pp. 469-474
-
-
Clark, R.H.1
Kueser, T.J.2
Walker, M.W.3
-
24
-
-
84873339299
-
Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012
-
Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580-637
-
(2013)
Crit Care Med
, vol.41
, pp. 580-637
-
-
Dellinger, R.P.1
Levy, M.M.2
Rhodes, A.3
-
25
-
-
33344468985
-
Translating research to clinical practice: A 1-year experience with implementing early goaldirected therapy for septic shock in the emergency department
-
Trzeciak S, Dellinger RP, Abate NL, et al: Translating research to clinical practice: A 1-year experience with implementing early goaldirected therapy for septic shock in the emergency department. Chest 2006;129:225-232
-
(2006)
Chest
, vol.129
, pp. 225-232
-
-
Trzeciak, S.1
Dellinger, R.P.2
Abate, N.L.3
-
26
-
-
0034099854
-
Use of nitric oxide inhalation in chronic obstructive pulmonary disease
-
Ashutosh K, Phadke K, Jackson JF, et al: Use of nitric oxide inhalation in chronic obstructive pulmonary disease. Thorax 2000;55:109-113
-
(2000)
Thorax
, vol.55
, pp. 109-113
-
-
Ashutosh, K.1
Phadke, K.2
Jackson, J.F.3
-
27
-
-
0030671323
-
Inhaled nitric oxide in patients with pulmonary embolism
-
Capellier G, Jacques T, Balvay P, et al: Inhaled nitric oxide in patients with pulmonary embolism. Intensive Care Med 1997;23:1089-1092
-
(1997)
Intensive Care Med
, vol.23
, pp. 1089-1092
-
-
Capellier, G.1
Jacques, T.2
Balvay, P.3
-
29
-
-
36248992450
-
Sidestream Dark Field (SDF) imaging: A novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation
-
Goedhart PT, Khalilzada M, Bezemer R, et al: Sidestream Dark Field (SDF) imaging: A novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express 2007;15:15101-15114
-
(2007)
Opt Express
, vol.15
, pp. 15101-15114
-
-
Goedhart, P.T.1
Khalilzada, M.2
Bezemer, R.3
-
30
-
-
0032828956
-
Orthogonal polarization spectral imaging: A new method for study of the microcirculation
-
Groner W, Winkelman JW, Harris AG, et al: Orthogonal polarization spectral imaging: A new method for study of the microcirculation. Nat Med 1999;5:1209-1212
-
(1999)
Nat Med
, vol.5
, pp. 1209-1212
-
-
Groner, W.1
Winkelman, J.W.2
Harris, A.G.3
-
31
-
-
0034967945
-
Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation
-
Mathura KR, Vollebregt KC, Boer K, et al: Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J Appl Physiol (1985) 2001;91:74-78
-
(2001)
J Appl Physiol (1985)
, vol.91
, pp. 74-78
-
-
Mathura, K.R.1
Vollebregt, K.C.2
Boer, K.3
-
32
-
-
0034352322
-
The Cytoscan Model E-II, a new reflectance microscope for intravital microscopy: Comparison with the standard fluorescence method
-
Harris AG, Sinitsina I, Messmer K: The Cytoscan Model E-II, a new reflectance microscope for intravital microscopy: Comparison with the standard fluorescence method. J Vasc Res 2000;37:469-476
-
(2000)
J Vasc Res
, vol.37
, pp. 469-476
-
-
Harris, A.G.1
Sinitsina, I.2
Messmer, K.3
-
33
-
-
4444233598
-
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
-
Sakr Y, Dubois MJ, De Backer D, et al: Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004;32:1825-1831
-
(2004)
Crit Care Med
, vol.32
, pp. 1825-1831
-
-
Sakr, Y.1
Dubois, M.J.2
De Backer, D.3
-
34
-
-
0032807347
-
Sublingual capnometry: A new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock
-
Weil MH, Nakagawa Y, Tang W, et al: Sublingual capnometry: A new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock. Crit Care Med 1999;27:1225-1229
-
(1999)
Crit Care Med
, vol.27
, pp. 1225-1229
-
-
Weil, M.H.1
Nakagawa, Y.2
Tang, W.3
-
35
-
-
84874934644
-
Microcirculatory alterations in patients with severe sepsis: Impact of time of assessment and relationship with outcome
-
De Backer D, Donadello K, Sakr Y, et al: Microcirculatory alterations in patients with severe sepsis: Impact of time of assessment and relationship with outcome. Crit Care Med 2013;41:791-799
-
(2013)
Crit Care Med
, vol.41
, pp. 791-799
-
-
De Backer, D.1
Donadello, K.2
Sakr, Y.3
-
36
-
-
33746032936
-
The measurement of blood and plasma nitrite by chemiluminescence: Pitfalls and solutions
-
Pelletier MM, Kleinbongard P, Ringwood L, et al: The measurement of blood and plasma nitrite by chemiluminescence: Pitfalls and solutions. Free Radic Biol Med 2006;41:541-548
-
(2006)
Free Radic Biol Med
, vol.41
, pp. 541-548
-
-
Pelletier, M.M.1
Kleinbongard, P.2
Ringwood, L.3
-
37
-
-
67649945779
-
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation
-
Jones AE, Trzeciak S, Kline JA: The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med 2009;37:1649-1654
-
(2009)
Crit Care Med
, vol.37
, pp. 1649-1654
-
-
Jones, A.E.1
Trzeciak, S.2
Kline, J.A.3
-
38
-
-
26444545385
-
Early changes in organ function predict eventual survival in severe sepsis
-
Levy MM, Macias WL, Vincent JL, et al: Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med 2005;33:2194-2201
-
(2005)
Crit Care Med
, vol.33
, pp. 2194-2201
-
-
Levy, M.M.1
Macias, W.L.2
Vincent, J.L.3
-
39
-
-
84880571478
-
An adaptive, phase II, dose-finding clinical trial design to evaluate L-carnitine in the treatment of septic shock based on efficacy and predictive probability of subsequent phase III success
-
Lewis RJ, Viele K, Broglio K, et al: An adaptive, phase II, dose-finding clinical trial design to evaluate L-carnitine in the treatment of septic shock based on efficacy and predictive probability of subsequent phase III success. Crit Care Med 2013;41:1674-1678
-
(2013)
Crit Care Med
, vol.41
, pp. 1674-1678
-
-
Lewis, R.J.1
Viele, K.2
Broglio, K.3
-
40
-
-
33750035526
-
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection
-
590.e1
-
Shapiro N, Howell MD, Bates DW, et al: The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med 2006;48:583-590, 590.e1
-
(2006)
Ann Emerg Med
, vol.48
, pp. 583-590
-
-
Shapiro, N.1
Howell, M.D.2
Bates, D.W.3
-
41
-
-
0035840891
-
Serial evaluation of the SOFA score to predict outcome in critically ill patients
-
Ferreira FL, Bota DP, Bross A, et al: Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001;286:1754-1758
-
(2001)
JAMA
, vol.286
, pp. 1754-1758
-
-
Ferreira, F.L.1
Bota, D.P.2
Bross, A.3
-
42
-
-
0036079693
-
Effect of a maldistribution of microvascular blood flow on capillary O (2) extraction in sepsis
-
Ellis CG, Bateman RM, Sharpe MD, et al: Effect of a maldistribution of microvascular blood flow on capillary O (2) extraction in sepsis. Am J Physiol Heart Circ Physiol 2002;282:H156-H164
-
(2002)
Am J Physiol Heart Circ Physiol
, vol.282
, pp. H156-H164
-
-
Ellis, C.G.1
Bateman, R.M.2
Sharpe, M.D.3
-
43
-
-
0030065143
-
Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis
-
Farquhar I, Martin CM, Lam C, et al: Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J Surg Res 1996;61:190-196
-
(1996)
J Surg Res
, vol.61
, pp. 190-196
-
-
Farquhar, I.1
Martin, C.M.2
Lam, C.3
-
44
-
-
0028053865
-
Microvascular perfusion is impaired in a rat model of normotensive sepsis
-
Lam C, Tyml K, Martin C, et al: Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 1994;94:2077-2083
-
(1994)
J Clin Invest
, vol.94
, pp. 2077-2083
-
-
Lam, C.1
Tyml, K.2
Martin, C.3
-
45
-
-
3643073477
-
Inhalation of nitric oxide in acute lung injury: Results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide
-
Lundin S, Mang H, Smithies M, et al: Inhalation of nitric oxide in acute lung injury: Results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide. Intensive Care Med 1999;25:911-919
-
(1999)
Intensive Care Med
, vol.25
, pp. 911-919
-
-
Lundin, S.1
Mang, H.2
Smithies, M.3
-
46
-
-
27144553471
-
The microcirculation is the motor of sepsis
-
Ince C: The microcirculation is the motor of sepsis. Crit Care 2005;9(Suppl 4):S13-S19
-
(2005)
Crit Care
, vol.9
, pp. S13-S19
-
-
Ince, C.1
-
47
-
-
0027477592
-
Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats
-
Hollenberg SM, Cunnion RE, Zimmerberg J: Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol 1993;264:H660-H663
-
(1993)
Am J Physiol
, vol.264
, pp. H660-H663
-
-
Hollenberg, S.M.1
Cunnion, R.E.2
Zimmerberg, J.3
-
48
-
-
0033210795
-
Effects of nitric oxide synthase inhibition on microvascular reactivity in septic mice
-
Hollenberg SM, Easington CR, Osman J, et al: Effects of nitric oxide synthase inhibition on microvascular reactivity in septic mice. Shock 1999;12:262-267
-
(1999)
Shock
, vol.12
, pp. 262-267
-
-
Hollenberg, S.M.1
Easington, C.R.2
Osman, J.3
-
49
-
-
0031004322
-
Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats
-
Hollenberg SM, Piotrowski MJ, Parrillo JE: Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats. Am J Physiol 1997;272:R969-R974
-
(1997)
Am J Physiol
, vol.272
, pp. R969-R974
-
-
Hollenberg, S.M.1
Piotrowski, M.J.2
Parrillo, J.E.3
-
50
-
-
0028895671
-
Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats
-
Avontuur JA, Bruining HA, Ince C: Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. Circ Res 1995;76:418-425
-
(1995)
Circ Res
, vol.76
, pp. 418-425
-
-
Avontuur, J.A.1
Bruining, H.A.2
Ince, C.3
-
51
-
-
0026507703
-
Nitric oxide modulates microvascular permeability
-
Kubes P, Granger DN: Nitric oxide modulates microvascular permeability. Am J Physiol 1992;262:H611-H615
-
(1992)
Am J Physiol
, vol.262
, pp. H611-H615
-
-
Kubes, P.1
Granger, D.N.2
-
52
-
-
0028254620
-
Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia
-
Nishida J, McCuskey RS, McDonnell D, et al: Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am J Physiol 1994;267:G1135-G1141
-
(1994)
Am J Physiol
, vol.267
, pp. G1135-G1141
-
-
Nishida, J.1
McCuskey, R.S.2
McDonnell, D.3
-
53
-
-
0028359689
-
Nitric oxide synthase inhibition aggravates intestinal microvascular vasoconstriction and hypoperfusion of bacteremia
-
Spain DA, Wilson MA, Bar-Natan MF, et al: Nitric oxide synthase inhibition aggravates intestinal microvascular vasoconstriction and hypoperfusion of bacteremia. J Trauma 1994;36:720-725
-
(1994)
J Trauma
, vol.36
, pp. 720-725
-
-
Spain, D.A.1
Wilson, M.A.2
Bar-Natan, M.F.3
-
54
-
-
0028088543
-
Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion
-
discussion 330-331
-
Spain DA, Wilson MA, Garrison RN: Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion. Surgery 1994;116:322-330; discussion 330-331
-
(1994)
Surgery
, vol.116
, pp. 322-330
-
-
Spain, D.A.1
Wilson, M.A.2
Garrison, R.N.3
-
55
-
-
0346998123
-
Effect of nitric oxide on capillary hemodynamics and cell injury in the pancreas during Pseudomonas pneumonia-induced sepsis
-
Tribl B, Bateman RM, Milkovich S, et al: Effect of nitric oxide on capillary hemodynamics and cell injury in the pancreas during Pseudomonas pneumonia-induced sepsis. Am J Physiol Heart Circ Physiol 2004;286:H340-H345
-
(2004)
Am J Physiol Heart Circ Physiol
, vol.286
, pp. H340-H345
-
-
Tribl, B.1
Bateman, R.M.2
Milkovich, S.3
-
56
-
-
4444273012
-
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock
-
López A, Lorente JA, Steingrub J, et al: Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock. Crit Care Med 2004;32:21-30
-
(2004)
Crit Care Med
, vol.32
, pp. 21-30
-
-
López, A.1
Lorente, J.A.2
Steingrub, J.3
-
57
-
-
0028302512
-
Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: Role of TNF-alpha and IL-1-beta
-
Cunha FQ, Assreuy J, Moss DW, et al: Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: Role of TNF-alpha and IL-1-beta. Immunology 1994;81:211-215
-
(1994)
Immunology
, vol.81
, pp. 211-215
-
-
Cunha, F.Q.1
Assreuy, J.2
Moss, D.W.3
-
58
-
-
0031867470
-
Differential expression of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats
-
Morin MJ, Unno N, Hodin RA, et al: Differential expression of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats. Crit Care Med 1998;26:1258-1264
-
(1998)
Crit Care Med
, vol.26
, pp. 1258-1264
-
-
Morin, M.J.1
Unno, N.2
Hodin, R.A.3
-
59
-
-
0032790876
-
Microcirculatory oxygenation and shunting in sepsis and shock
-
Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999;27:1369-1377
-
(1999)
Crit Care Med
, vol.27
, pp. 1369-1377
-
-
Ince, C.1
Sinaasappel, M.2
-
60
-
-
0031975630
-
Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: Results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group
-
Dellinger RP, Zimmerman JL, Taylor RW, et al: Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: Results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med 1998;26:15-23
-
(1998)
Crit Care Med
, vol.26
, pp. 15-23
-
-
Dellinger, R.P.1
Zimmerman, J.L.2
Taylor, R.W.3
-
61
-
-
1842433745
-
Low-dose inhaled nitric oxide in patients with acute lung injury: A randomized controlled trial
-
Taylor RW, Zimmerman JL, Dellinger RP, et al; Inhaled Nitric Oxide in ARDS Study Group: Low-dose inhaled nitric oxide in patients with acute lung injury: A randomized controlled trial. JAMA 2004;291:1603-1609
-
(2004)
JAMA
, vol.291
, pp. 1603-1609
-
-
Taylor, R.W.1
Zimmerman, J.L.2
Dellinger, R.P.3
-
62
-
-
33745698607
-
Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury
-
Hataishi R, Rodrigues AC, Neilan TG, et al: Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2006;291:H379-H384
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.291
, pp. H379-H384
-
-
Hataishi, R.1
Rodrigues, A.C.2
Neilan, T.G.3
-
63
-
-
34547841668
-
Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion
-
Liu X, Huang Y, Pokreisz P, et al: Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion. J Am Coll Cardiol 2007;50:808-817
-
(2007)
J Am Coll Cardiol
, vol.50
, pp. 808-817
-
-
Liu, X.1
Huang, Y.2
Pokreisz, P.3
-
64
-
-
1842301160
-
Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine
-
Troncy E, Francoeur M, Salazkin I, et al: Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine. Br J Anaesth 1997;79:631-640
-
(1997)
Br J Anaesth
, vol.79
, pp. 631-640
-
-
Troncy, E.1
Francoeur, M.2
Salazkin, I.3
-
65
-
-
0031022475
-
Delayed administration of inhaled nitric oxide preserves alveolar-capillary membrane integrity in porcine gram-negative sepsis
-
Bloomfield GL, Sweeney LB, Fisher BJ, et al: Delayed administration of inhaled nitric oxide preserves alveolar-capillary membrane integrity in porcine gram-negative sepsis. Arch Surg 1997;132:65-75
-
(1997)
Arch Surg
, vol.132
, pp. 65-75
-
-
Bloomfield, G.L.1
Sweeney, L.B.2
Fisher, B.J.3
-
66
-
-
0033933496
-
Inhaled NO reduces leukocyteendothelial cell interactions and myocardial dysfunction in endotoxemic rats
-
Nevière R, Guery B, Mordon S, et al: Inhaled NO reduces leukocyteendothelial cell interactions and myocardial dysfunction in endotoxemic rats. Am J Physiol Heart Circ Physiol 2000;278:H1783-H1790
-
(2000)
Am J Physiol Heart Circ Physiol
, vol.278
, pp. H1783-H1790
-
-
Nevière, R.1
Guery, B.2
Mordon, S.3
-
67
-
-
0033369386
-
Inhaled NO reaches distal vasculatures to inhibit endothelium-but not leukocyte-dependent cell adhesion
-
Fox-Robichaud A, Payne D, Kubes P: Inhaled NO reaches distal vasculatures to inhibit endothelium-but not leukocyte-dependent cell adhesion. Am J Physiol 1999;277:L1224-L1231
-
(1999)
Am J Physiol
, vol.277
, pp. L1224-L1231
-
-
Fox-Robichaud, A.1
Payne, D.2
Kubes, P.3
-
68
-
-
0032850417
-
Inhaled NO impacts vascular but not extravascular compartments in postischemic peripheral organs
-
Kubes P, Payne D, Grisham MB, et al: Inhaled NO impacts vascular but not extravascular compartments in postischemic peripheral organs. Am J Physiol 1999;277:H676-H682
-
(1999)
Am J Physiol
, vol.277
, pp. H676-H682
-
-
Kubes, P.1
Payne, D.2
Grisham, M.B.3
-
69
-
-
0028102136
-
NO donors prevent integrin-induced leukocyte adhesion but not P-selectin-dependent rolling in postischemic venules
-
Kubes P, Kurose I, Granger DN: NO donors prevent integrin-induced leukocyte adhesion but not P-selectin-dependent rolling in postischemic venules. Am J Physiol 1994;267:H931-H937
-
(1994)
Am J Physiol
, vol.267
, pp. H931-H937
-
-
Kubes, P.1
Kurose, I.2
Granger, D.N.3
-
70
-
-
0032964751
-
Nitric oxide reduces the sequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18 expression
-
Sato Y, Walley KR, Klut ME, et al: Nitric oxide reduces the sequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18 expression. Am J Respir Crit Care Med 1999;159:1469-1476
-
(1999)
Am J Respir Crit Care Med
, vol.159
, pp. 1469-1476
-
-
Sato, Y.1
Walley, K.R.2
Klut, M.E.3
-
71
-
-
0032814499
-
Modulation of proinflammatory cytokines by nitric oxide in murine acute lung injury
-
Walley KR, McDonald TE, Higashimoto Y, et al: Modulation of proinflammatory cytokines by nitric oxide in murine acute lung injury. Am J Respir Crit Care Med 1999;160:698-704
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 698-704
-
-
Walley, K.R.1
McDonald, T.E.2
Higashimoto, Y.3
-
72
-
-
31344453457
-
The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
-
De Backer D, Creteur J, Dubois MJ, et al: The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006;34:403-408
-
(2006)
Crit Care Med
, vol.34
, pp. 403-408
-
-
De Backer, D.1
Creteur, J.2
Dubois, M.J.3
-
73
-
-
84870716047
-
Systemic and microcirculatory effects of dobutamine in patients with septic shock
-
Enrico C, Kanoore Edul VS, Vazquez AR, et al: Systemic and microcirculatory effects of dobutamine in patients with septic shock. J Crit Care 2012;27:630-638
-
(2012)
J Crit Care
, vol.27
, pp. 630-638
-
-
Enrico, C.1
Kanoore Edul, V.S.2
Vazquez, A.R.3
-
74
-
-
78650368315
-
Levosimendan for resuscitating the microcirculation in patients with septic shock: A randomized controlled study
-
Morelli A, Donati A, Ertmer C, et al: Levosimendan for resuscitating the microcirculation in patients with septic shock: A randomized controlled study. Crit Care 2010;14:R232
-
(2010)
Crit Care
, vol.14
, pp. R232
-
-
Morelli, A.1
Donati, A.2
Ertmer, C.3
-
75
-
-
33745603201
-
Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis
-
De Backer D, Verdant C, Chierego M, et al: Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 2006;34:1918-1924
-
(2006)
Crit Care Med
, vol.34
, pp. 1918-1924
-
-
De Backer, D.1
Verdant, C.2
Chierego, M.3
-
76
-
-
74049118733
-
Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial
-
Boerma EC, Koopmans M, Konijn A, et al: Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial. Crit Care Med 2010;38:93-100
-
(2010)
Crit Care Med
, vol.38
, pp. 93-100
-
-
Boerma, E.C.1
Koopmans, M.2
Konijn, A.3
-
77
-
-
84866562435
-
Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock
-
He X, Su F, Velissaris D, et al: Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock. Crit Care Med 2012;40:2833-2840
-
(2012)
Crit Care Med
, vol.40
, pp. 2833-2840
-
-
He, X.1
Su, F.2
Velissaris, D.3
-
78
-
-
4043128084
-
Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation
-
Singer M, De Santis V, Vitale D, et al: Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 2004;364:545-548
-
(2004)
Lancet
, vol.364
, pp. 545-548
-
-
Singer, M.1
De Santis, V.2
Vitale, D.3
|