Blood-Brain Barrier Proteomics: Towards the Understanding of Neurodegenerative Diseases

Archives of Medical Research

Volumn 45, Issue 8, 2014, Pages 730-737

  Karamanos, Yannis ^a   Gosselet, Fabien ^a   Dehouck, Marie Pierre ^a   Cecchelli, Roméo ^a  

^a Laboratoire de la Barrière Hématoencéphalique   (France)

Author keywords

BBB; Blood brain barrier; Endothelial cells; Neurodegenerative disease; Proteomics

Indexed keywords

CELL MEMBRANE PROTEIN; TIGHT JUNCTION PROTEIN;

ACCURACY; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN METABOLISM; DEGENERATIVE DISEASE; HOMEOSTASIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEOMICS; QUANTITATIVE ANALYSIS; REVIEW; CELL MEMBRANE; METABOLISM; MICROVASCULATURE; PHYSIOLOGY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL; VASCULAR ENDOTHELIUM;

BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CELL MEMBRANE; ENDOTHELIUM, VASCULAR; HUMANS; MICROVESSELS; NEURODEGENERATIVE DISEASES; PROTEOMICS;

EID: 84924807037     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2014.11.008     Document Type: Review

References (47)

1. Cecchelli R., Berezowski V., Lundquist S., et al. Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 2007, 6:650-661.
2. Armulik A., Genové G., Mäe M., et al. Pericytes regulate the blood-brain barrier. Nature 2010, 468:557-561.
3. Abbott N.J., Patabendige A.A.K., Dolman D.E.M., et al. Structure and function of the blood-brain barrier. Neurobiol Dis 2010, 37:13-25.
4. Nag S. Morphology and properties of brain endothelial cells. Methods Mol Biol 2011, 686:3-47.
5. Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005, 57:173-185.
6. Howes M.T., Mayor S., Parton R.G. Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis. Curr Opin Cell Biol 2010, 22:519-527.
7. Kelly B.T., Owen D.J. Endocytic sorting of transmembrane protein cargo. Curr Opin Cell Biol 2011, 23:404-412.
8. O'Bryan J.P. Intersecting pathways in cell biology. Sci Signal 2010, 3:re10.
9. Reider A., Wendland B. Endocytic adaptors-social networking at the plasma membrane. J Cell Sci 2011, 124:1613-1622.
10. Leth-Larsen R., Lund R.R., Ditzel H.J. Plasma membrane proteomics and its application in clinical cancer biomarker discovery. Mol Cell Proteomics 2010, 9:1369-1382.
11. Pottiez G., Flahaut C., Cecchelli R., et al. Understanding the blood-brain barrier using gene and protein expression profiling technologies. Brain Res Rev 2009, 62:83-98.
12. Calabria A.R., Shusta E.V. Blood-brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery. Drug Discov Today 2006, 11:792-799.
13. Lu L., Yang P.Y., Rui Y.C., et al. Comparative proteome analysis of rat brain and coronary microvascular endothelial cells. Physiol Res 2007, 56:159-168.
14. Pellieux C., Desgeorges A., Pigeon C.H., et al. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. J Biol Chem 2003, 278:29136-29144.
15. Ohtsuki S., Uchida Y., Kubo Y., et al. Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects. J Pharm Sci 2011, 100:3547-3559.
16. Deracinois B., Flahaut C., Duban-Deweer S., et al. Comparative and quantitative global proteomics approaches: an overview. Proteomes 2013, 1:180-218.
17. Shusta E.V. Blood-brain barrier genomics, proteomics, and new transporter discovery. NeuroRx 2005, 2:151-161.
18. Ohtsuki S., Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res 2007, 24:1745-1758.
19. Ohtsuki S., Hirayama M., Ito S., et al. Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics. Expert Rev Proteomics 2014, 11:303-313.
20. Murugesan N., Macdonald J.A., Lu Q., et al. Analysis of mouse brain microvascular endothelium using laser capture microdissection coupled with proteomics. Methods Mol Biol 2011, 686:297-311.
21. Pottiez G., Sevin E., Cecchelli R., et al. Actin, gelsolin and filamin-A are dynamic actors in the cytoskeleton remodelling contributing to the blood brain barrier phenotype. Proteomics 2009, 9:1207-1219.
22. Dehouck M.P., Jolliet-Riant P., Brée F., et al. Drug transfer across the blood-brain barrier: correlation between invitro and invivo models. J Neurochem 1992, 58:1790-1797.
23. Duban-Deweer S., Flahaut C., Karamanos Y. The proteome of brain capillary endothelial cells: towards a molecular characterization of an invitro blood-brain barrier model. Expression Profiling in Neuroscience 2012, 161-179. Humana Press, New York. Y. Karamanos (Ed.).
24. Pottiez G., Duban-Deweer S., Deracinois B., et al. A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells. J Proteomics 2011, 75:628-641.
25. Deracinois B., Pottiez G., Chafey P., et al. Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study. Proteomics 2013, 13:1185-1199.
26. Deracinois B., Duban-Deweer S., Pottiez G., et al. TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. PLoS One 2012, 7:e48428.
27. Pottiez G., Deracinois B., Duban-Deweer S., et al. A large-scale electrophoresis- and chromatography-based determination of gene expression profiles in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. Proteome Sci 2010, 8:57.
28. Karamanos Y. Studying molecular aspects of the blood-brain barrier using an invitro model: contribution of a global proteomics strategy. J Biosci Med 2014, 02:18-25.
29. Duban-Deweer S., Hachani J., Deracinois B., et al. Proteomic analysis of plasma membrane proteins in an invitro blood-brain barrier model. Proteomics-Human Diseases and Protein Functions 2012, 391-416. InTech, Rijeka, Croatia. T.K. Man, J. Flores (Eds.).
30. Kamiie J., Ohtsuki S., Iwase R., et al. Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm Res 2008, 25:1469-1483.
31. Agarwal S., Uchida Y., Mittapalli R.K., et al. Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and P-gp/Bcrp knockout mice. Drug Metab Dispos 2012, 40:1164-1169.
32. Haseloff R.F., Krause E., Bigl M., et al. Differential protein expression in brain capillary endothelial cells induced by hypoxia and posthypoxic reoxygenation. Proteomics 2006, 6:1803-1809.
33. Haqqani A.S., Nesic M., Preston E., et al. Characterization of vascular protein expression patterns in cerebral ischemia/reperfusion using laser capture microdissection and ICAT-nanoLC-MS/MS. FASEB J 2005, 19:1809-1821.
34. Haqqani A.S., Kelly J., Baumann E., et al. Protein markers of ischemic insult in brain endothelial cells identified using 2D gel electrophoresis and ICAT-based quantitative proteomics. J Proteome Res 2007, 6:226-239.
35. Zhang W., Mojsilovic-Petrovic J., Andrade M.F., et al. The expression and functional characterization of ABCG2 in brain endothelial cells and vessels. FASEB J 2003, 17:2085-2087.
36. Onodera H., Arito M., Sato T., et al. Novel effects of edaravone on human brain microvascular endothelial cells revealed by a proteomic approach. Brain Res 2013, 1534:87-94.
37. Campos-Martorell M., Salvador N., Monge M., et al. Brain proteomics identifies potential simvastatin targets in acute phase of stroke in a rat embolic model. J Neurochem 2014, 130:301-312.
38. Keeney J.T.R., Swomley A.M., Förster S., et al. Apolipoprotein A-I: insights from redox proteomics for its role in neurodegeneration. Proteomics Clin Appl 2013, 7:109-122.
39. Ricardo-Dukelow M., Kadiu I., Rozek W., et al. HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia. J Neuroimmunol 2007, 185:37-46.
40. Ouyang S., Hsuchou H., Kastin A.J., et al. Diet-induced obesity suppresses expression of many proteins at the blood-brain barrier. J Cereb Blood Flow Metab 2014, 34:43-51.
41. Alexander J.S., Minagar A., Harper M., et al. Proteomic analysis of human cerebral endothelial cells activated by multiple sclerosis serum and IFNbeta-1b. J Mol Neurosci 2007, 32:169-178.
42. Hutamekalin P., Farkas A.E., Orbók A., et al. Effect of nicotine and polyaromatic hydrocarbons on cerebral endothelial cells. Cell Biol Int 2008, 32:198-209.
43. Wilhelm M., Schlegl J., Hahne H., et al. Mass-spectrometry-based draft of the human proteome. Nature 2014, 509:582-587.
44. Shawahna R., Uchida Y., Declèves X., et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharmacol 2011, 8:1332-1341.
45. Lippmann E.S., Azarin S.M., Kay J.E., et al. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol 2012, 30:783-791.
46. Cecchelli R., Aday S., Sevin E., et al. A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells. PLoS One 2014, 9:e99733.
47. Nakagawa S., Deli M.A., Kawaguchi H., et al. A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochem Int 2009, 54:253-256.