Proteomic analysis of human cerebral endothelial cells activated by multiple sclerosis serum and IFNβ-1b

Journal of Molecular Neuroscience

Volumn 32, Issue 3, 2007, Pages 169-178

  Alexander, J Steven ^a   Minagar, Alireza ^b   Harper, Michael ^a   Robinson Jackson, Sherry ^a   Jennings, Merilyn ^a   Smith, Stacy J ^b  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Louisiana State University School of Medicine Shreveport   (United States)

Author keywords

14 3 3; Cerebral endothelial cells; MALDI TOF; Multiple sclerosis; Proteomic; RAP 1A

Indexed keywords

INTERFERON BETA SERINE; LIPOCORTIN 1; METAVINCULIN; MYOSIN; PLASMINOGEN; PROTEIN; PROTEIN 14 3 3; RAP1 PROTEIN; RETICULOCALBIN 2; RETICULOCALBIN 3; RIBONUCLEASE; TROPOMYOSIN; UNCLASSIFIED DRUG;

ADULT; ANGIOGENESIS; ARTICLE; BRAIN; CASE REPORT; CELL ACTIVATION; CELL CYCLE REGULATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MULTIPLE SCLEROSIS; PROTEIN EXPRESSION; PROTEOMICS; RELAPSE; SERUM; TWO DIMENSIONAL GEL ELECTROPHORESIS; UPREGULATION;

ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOTHELIUM, VASCULAR; HUMANS; INTERFERON-BETA; MOLECULAR WEIGHT; MULTIPLE SCLEROSIS; NERVE TISSUE PROTEINS; PEPTIDE MAPPING; PROTEOME; RECOMBINANT PROTEINS; REFERENCE VALUES;

EID: 35348841487     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-007-0018-3     Document Type: Article

References (48)

1. Alt, C., Duvefelt, K., Franzen, B., Yang, Y., & Engelhardt, B. (2005). Gene and protein expression profiling of the microvascular compartment in experimental autoimmune encephalomyelitis in C57Bl/6 and SJL mice. Brain Pathology, 15, 1-16.
2. Alvarez-Martinez, M. T., Porte, F., Liautard, J. P., & Sri Widada, J. (1997). Effects of profilin-annexin I association on some properties of both profilin and annexin I: Modification of the inhibitory activity of profilin on actin polymerization and inhibition of the self-association of annexin I and its interactions with liposomes. Biochimica et Biophysica Acta, 1339, 331-340.
3. Badet, J., Soncin, F., N'Guyen, T., & Barritault, D. (1990). In vivo and in vitro studies of angiogenin - A potent angiogenic factor. Blood Coagulation & Fibrinolysis, 1, 721-724.
4. Bomsztyk, K., Van Seuningen, I., Suzuki, H., Denisenko, O., & Ostrowski, J. (1997). Diverse molecular interactions of the hnRNP K protein. FEBS Letters, 403, 113-115.
5. Burgess-Cassler, A., Johansen, J. J., Santek, D. A., Ide, J.R., & Kendrick, N. C. (1989). Computerized quantitative analysis of coomassie-blue-stained serum proteins separated by two-dimensional electrophoresis. Clinical Chemistry, 35, 2297-2304.
6. Carlson, N. G., & Rose, J. W. (2006). Antioxidants in multiple sclerosis: Do they have a role in therapy? CNS Drugs, 20, 433-441.
7. Carper, D., John, M., Chen, Z., Subramanian, S., Wang, R., Ma, W., et al. (2001). Gene expression analysis of an H(2)O(2)-resistant lens epithelial cell line. Free Radical Biology & Medicine, 31, 90-97.
8. Chen, J. M., Grad, R., Monaco, R., & Pincus, M. R. (1996a). Prediction of the three-dimensional structure of the rap-1A protein from its homology to the ras-gene-encoded p21 protein. Journal of Protein Chemistry, 15, 11-15.
9. Chen, J. M., Manolatos, S., Brandt-Rauf, P. W., Murphy, R. B., Monaco, R., & Pincus, M. R. (1996b). Computed three-dimensional structures for the ras-binding domain of the raf-p74 protein complexed with ras-p21 and with its suppressor protein, rap-1A. Journal of Protein Chemistry, 15, 511-518.
10. Chen, J. M., Monaco, R., Manolatos, S., Brandt-Rauf, P. W., Friedman, F. K., & Pincus, M. R. (1997). Molecular Dynamics on complexes of ras-p21 and its inhibitor protein, rap-1A, bound to the ras-binding domain of the raf-p74 protein: Identification of effector domains in the raf-protein. Journal of Protein Chemistry, 16, 619-629.
11. Chiba, S., Yokota, S., Yonekura, K., Tanaka, S., Furuyama, H., Kubota, H. et al. (2006). Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis. Journal of the Neurological Sciences, 241, 39-43.
12. Colucci, M., Roccatagliata, L., Capello, E., Narciso, E., Latronico, N., Tabaton, M., et al. (2004). The 14-3-3 protein in multiple sclerosis: A marker of disease severity. Multiple Sclerosis, 10, 477-481.
13. Dreier, R., Schmid, K. W., Gerke, V., & Riehemann, K. (1998). Differential expression of annexins I, II, and IV in human tissues: An immunohistochemical study. Histochemistry & Cell Biology, 110, 137-148.
14. D'Acquisto, F., Merghani, A., Lecona, E., Rosignoli, G., Raza, K., Buckley, C.D., et al. (2007). Annexin-1 modulates T-cell activation and differentiation. Blood, 109, 1095-1102.
15. Franzen, B., Duvefelt, K., Jonsson, C., Engelhardt, B., Ottervald, J., Wickman, M., et al. (2003). Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-alpha. Brain Research Molecular Brain Research, 115, 130-146.
16. Frohman, E. M., Racke, M. K., & Raine, C. S. (2006). Multiple sclerosis-the plaque and its pathogenesis. New England Journal of Medicine, 354, 942-955.
17. Ghitescu, L. D., Gugliucci, A., & Dumas, F. (2001). Annexins I and II are among the main endothelial plasmalemma-associated proteins forming early glucose adducts in experimental diabetes. Diabetes, 50, 1666-1674.
18. Hengstschlager, M., Rosner, M., Fountoulakis, M., & Lubec, G. (2005). The cellular response to ectopic overexpression of the tuberous sclerosis genes, TSC1 and TSC2: A proteomic approach. International Journal of Oncology, 27, 831-838.
19. Honore, B., & Vorum, H. (2000). The CREC family, a novel family of multiple EF-hand, low-affinity Ca(2+)-binding proteins localised to the secretory pathway of mammalian cells. FEBS Letter, 466, 11-18.
20. Huitinga, I., Bauer, J., Strijbos, P. J., Rothwell, N. J., Dijkstra, C. D., & Tilders, F. J. (1998). Effects of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat. Clinical and Experimental Immunology, 111, 198-204.
21. Imitola, J., Chitnis, T., & Khoury, S. J. (2006). Insights into the molecular pathogenesis of progression in multiple sclerosis: Potential implications for future therapies. Archives of Neurology, 63, 25-33.
22. Kaneko, K., & Hachiya, N. S. (2006). The alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditions. Medical Hypotheses, 67, 169-171.
23. Li, J. M., & Shah, A. M. (2003). Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit. Journal of Biological Chemistry, 278, 12094-12100.
24. Martinez-Yelamos, A., Rovira, A., Sanchez-Valle, R., Martinez-Yelamos, S., Tintore, M., Blanco, Y., et al. (2004). CSF 14-3-3 protein assay and MRI as prognostic markers in patients with a clinically isolated syndrome suggestive of MS. Journal of Neurology, 251, 1278-1279.
25. McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H. P., Lublin, F. D., et al. (2001). Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Annals of Neurology, 50, 121-127.
26. Minagar, A., & Alexander, J. S. (2003). Blood-brain barrier disruption in multiple sclerosis. Multiple Sclerosis, 9, 540-549.
27. Minagar, A., Ostanin, D., Long, A. C., Jennings, M., Kelley, R. E., Sasaki, M., et al. (2003). Serum from patients with multiple sclerosis downregulates occludin isoforms and VE-cadherin expression in cultured endothelial cells. Multiple Sclerosis, 9, 235-238.
28. Morales, Y., Parisi, J. E., & Lucchinetti, C. F. (2006). The pathology of multiple sclerosis: Evidence for heterogeneity. Advances in Neurology, 98, 27-45.
29. Morand, E. F., Hall, P., Hutchinson, P., & Yang, Y. H. (2006). Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. Mediators of Inflammation, 2006, 1-6.
30. Norton, W. T., Brosnan, C. F., Cammer, W., & Goldmuntz, E. A. (1990). Mechanisms and suppression of inflammatory demyelination. Acta Neurobiologiae Experimentalis (Wars), 50, 225-235.
31. Noseworthy, J. H., Lucchinetti, C., Rodriguez, M., & Weinshenker, B. G. (2000). Multiple sclerosis. New England Journal of Medicine, 343, 938-952.
32. Oakley, B. R., Kirsch, D. R., & Morris, N. R. (1980). A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels. Analytical Biochemistry, 105, 361-363.
33. O'Farrell, P. H. (1975). High resolution two-dimensional electrophoresis of proteins. Journal of Biological Chemistry, 250, 4007-4021.
34. Probst-Cousin, S., Kowolik, D., Kuchelmeister, K., Kayser, C., Neundorfer, B., & Heuss, D. (2002). Expression of annexin-1 in multiple sclerosis plaques. Neuropathology & Applied Neurobiology, 4, 292-300.
35. Quinn, M. T., Parkos, C. A., & Jesaitis, A. J. (1995). Purification of human neutrophil NADPH oxidase cytochrome b-558 and association with RAP 1A. Methods in Enzymology, 255, 476-487.
36. Rodrigo, J. P., Garcia-Pedrero, J. M., Gonzalez, M. V., Fernandez, M. P., Suarez, C., & Herrero, A. (2004). Expression of annexin A1 in normal and chronically inflamed nasal mucosa. Archives of Otolaryngology, Head & Neck Surgery, 130, 211-215.
37. Satoh, J., Yamamura, T., & Arima, K. (2004). The 14-3-3 protein epsilon isoforms expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes. American Journal of Pathology, 165, 577-592.
38. Satoh, J. I., Tabunoki, H., Nanri, Y., Arima, K., & Yamamura, T. (2006). Human astrocytes express 14-3-3 sigma in response to oxidative and DNA-damaging stresses. Neuroscience Research, 56, 61-72.
39. Sawmynaden, P., & Perretti, M. (2006). Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes. Biochemical and Biophysical Research Communications, 349, 1351-1355.
40. Schneider, R., Schneider-Scherzer, E., Thurnher, M., Auer, B., & Schweiger, M. (1998). The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. EMBO Journal, 7, 4151-4156.
41. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., et al. (1985). Measurement of protein using bicinchoninic acid. Analytical Biochemistry, 150, 76-85.
42. Stone, L. A., Frank, J. A., Albert, P. S., Bash, C., Smith, M. E., Maloni, H., et al. (1995). The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis. Annals of Neurology, 37, 611-619.
43. Su, J. J., Osoegawa, M., Matsuoka, T., Minohara, M., Tanaka, M., Ishizu, T., et al. (2006). Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings. Journal of the Neurological Sciences, 243, 21-30.
44. Teunissen, C. E., Dijkstra, C., & Polman, C. (2005). Biological markers in CSF and blood for axonal degeneration in multiple sclerosis. Lancet Neurology, 4, 32-41.
45. Thisted, T., Lyakhov, D. L., & Liebhaber, S. A. (2001). Optimized RNA targets of two closely related triple KH domain proteins, heterogeneous nuclear ribonucleoprotein K and alphaCP-2KL, suggest distinct modes of RNA recognition. Journal of Biological Chemistry, 276, 17484-17496.
46. van Horssen, J., Schreibelt, G., Bo, L., Montagne, L., Drukarch, B., van Muiswinkel, F. L., et al. (2006). NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions. Free Radical Biology & Medicine, 41, 311-317.
47. Wolthuis, R. M., Bauer, B., van't Veer, L. J., de Vries-Smits, A. M., Cool, R. H, Spaargaren, M., et al. (1996). RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Oncogene, 13, 353-362.
48. Yong, V. W. (2002). Differential mechanisms of action of interferon-beta and glatiramer acetate in MS. Neurology, 59, 802-808.