Obstructive sleep apnea is associated with fatigue in multiple sclerosis

Multiple Sclerosis Journal

Volumn 18, Issue 8, 2012, Pages 1159-1169

  Kaminska, M ^a   Kimoff, R J ^a   Benedetti, A ^a   Robinson, A ^a   Bar Or, A ^b   Lapierre, Y ^b   Schwartzman, K ^a   Trojan, D A ^b  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

fatigue; multiple sclerosis; patient related outcome measures; polysomnography; sleep apnea syndromes; sleep disorders

Indexed keywords

ADULT; AGED; APNEA HYPOPNEA INDEX; ARTICLE; BODY MASS; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; EPWORTH SLEEPINESS SCALE; EXPANDED DISABILITY STATUS SCALE; FATIGUE; FATIGUE SEVERITY SCALE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDIMENSIONAL FATIGUE INVENTORY; MULTIPLE SCLEROSIS; NOCTURIA; PAIN; RATING SCALE; RESTLESS LEGS SYNDROME; SLEEP APNEA SYNDROME;

EID: 84859440654     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458511432328     Document Type: Article

References (62)

1. Kos D, Kerckhofs E, Nagels G, D'hooghe MB, Ilsbroukx S. Origin of fatigue in multiple sclerosis: review of the literature. Neurorehabil Neural Repair. 2008 ; 22: 91-100
2. Jongbloed L. Disability incomes: The experiences of women with multiple sclerosis. Can J Occupat Therapy. 1998 ; 65: 193-201
3. Trojan DA, Arnold D, Collet JP, et al. Fatigue in multiple sclerosis: association with disease-related, behavioural and psychosocial factors. Mult Scler. 2007 ; 13: 985-995
4. Chervin RD. Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea. Chest. 2000 ; 118: 372-379
5. Guilleminault C, Lopes MC, Hagen CC, da RA. The cyclic alternating pattern demonstrates increased sleep instability and correlates with fatigue and sleepiness in adults with upper airway resistance syndrome. Sleep. 2007 ; 30: 641-647
6. Yue HJ, Bardwell W, ncoli-Israel S, Loredo JS, Dimsdale JE. Arousal frequency is associated with increased fatigue in obstructive sleep apnea. Sleep Breath. 2009 ;:
7. Veauthier C, Radbruch H, Gaede G, et al. Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study. Mult Scler. 2011 ; 17: 613-622
8. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001 ; 50: 121-127
9. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 ; 28: 193-213
10. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med ; ;. 101.
11. Walters AS, LeBrocq C, Dhar A, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003 ; 4: 121-132
12. Hublin C, Kaprio J, Partinen M, et al. The prevalence of narcolepsy: an epidemiological study of the Finnish Twin Cohort. Ann Neurol. 1994 ; 35: 709-716
13. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989 ; 46: 1121-1123
14. Smets EM, Garssen B, Cull A, de Haes JC. Application of the multidimensional fatigue inventory (MFI-20) in cancer patients receiving radiotherapy. Br J Cancer. 1996 ; 73: 241-245
15. Putzki N, Katsarava Z, Vago S, Diener HC, Limmroth V. Prevalence and severity of multiple-sclerosis-associated fatigue in treated and untreated patients. Eur Neurol. 2008 ; 59: 136-142
16. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 ; 14: 540-545
17. Radloff LS. The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Measure. 1977 ; 1: 385-401
18. Verdier-Taillefer MH, Gourlet V, Fuhrer R, Alperovitch A. Psychometric properties of the Center for Epidemiologic Studies-Depression scale in multiple sclerosis. Neuroepidemiology. 2001 ; 20: 262-267
19. Iber C, Ancoli-Israel S, Chesson A, Quan S The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 1 st ed.Westchester, IL: AASM, 2007. Westchester, IL: AASM ; 2007 :
20. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep. 1999 ; 22: 667-689
21. Carskadon MA, Dement WC, Mitler MM, Roth T, Westbrook PR, Keenan S. Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness. Sleep. 1986 ; 9: 519-524
22. Arand D, Bonnet M, Hurwitz T, Mitler M, Rosa R, Sangal RB. The clinical use of the MSLT and MWT. Sleep. 2005 ; 28: 123-144
23. Scaglione C, Vignatelli L, Plazzi G, et al. REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study. Neurol Sci. 2005 ; 25: 316-321
24. The International Classification of Sleep Disorders. Diagnostic & Coding Manual. 2 nd ed.Westchester, IL: American Academy of Sleep Medicine, 2005. Westchester, IL: American Academy of Sleep Medicine ; 2005 :
25. R: A language and environment for statistical computing. R Foundation for Statistical Computing ; 2008 2008 :
26. Tomfohr LM, Ancoli-Israel S, Loredo JS, Dimsdale JE. Effects of continuous positive airway pressure on fatigue and sleepiness in patients with obstructive sleep apnea: data from a randomized controlled trial. Sleep. 2011 ; 34: 121-126
27. Roelcke U, Kappos L, Lechner-Scott J, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997 ; 48: 1566-1571
28. Inglese M, Park SJ, Johnson G, et al. Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Arch Neurol. 2007 ; 64: 196-202
29. Macey PM, Henderson LA, Macey KE, et al. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med. 2002 ; 166: 1382-1387
30. Morrell MJ, McRobbie DW, Quest RA, Cummin AR, Ghiassi R, Corfield DR. Changes in brain morphology associated with obstructive sleep apnea. Sleep Med. 2003 ; 4: 451-454
31. Leocani L, Colombo B, Comi G. Physiopathology of fatigue in multiple sclerosis. Neurol Sci. 2008 ; 29 (Suppl. 2). S241 - S243
32. Macey KE, Macey PM, Woo MA, et al. Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea. Respir Physiol Neurobiol. 2006 ; 151: 44-60
33. Flachenecker P, Bihler I, Weber F, Gottschalk M, Toyka KV, Rieckmann P. Cytokine mRNA expression in patients with multiple sclerosis and fatigue. Mult Scler. 2004 ; 10: 165-169
34. Gozal D, Kheirandish-Gozal L. Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more. Am J Respir Crit Care Med. 2008 ; 177: 369-375
35. Silverman MN, Heim CM, Nater UM, Marques AH, Sternberg EM. Neuroendocrine and immune contributors to fatigue. PM R. 2010 ; 2: 338-346
36. Carlson JT, Hedner J, Elam M, Ejnell H, Sellgren J, Wallin BG. Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest. 1993 ; 103: 1763-1768
37. Ciftci TU, Kokturk O, Ozkan S. Apnea-hypopnea indexes calculated using different hypopnea definitions and their relation to major symptoms. Sleep Breath. 2004 ; 8: 141-146
38. Redline S, Kapur VK, Sanders MH, et al. Effects of varying approaches for identifying respiratory disturbances on sleep apnea assessment. Am J Respir Crit Care Med. 2000 ; 161: 369-374
39. Ruehland WR, Rochford PD, O'Donoghue FJ, Pierce RJ, Singh P, Thornton AT. The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index. Sleep. 2009 ; 32: 150-157
40. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993 ; 328: 1230-1235
41. Achiron A, Barak Y, Gabbay U, et al. Sleep disturbance in multiple sclerosis:clinical and neuroradiologic correlations related to disease activity. J Neuroimmunol. 1995 ; 57 (Suppl. 1). 56-63
42. Tachibana N, Howard RS, Hirsch NP, Miller DH, Moseley IF, Fish D. Sleep problems in multiple sclerosis. Eur Neurol. 1994 ; 34: 320-323
43. Younes M. Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. J Appl Physiol. 2008 ; 105: 1389-1405
44. Mediano O, Barcelo A, de la Pena M, Gozal D, Agusti A, Barbe F. Daytime sleepiness and polysomnographic variables in sleep apnoea patients. Eur Respir J. 2007 ; 30: 110-113
45. Sauter C, Asenbaum S, Popovic R, et al. Excessive daytime sleepiness in patients suffering from different levels of obstructive sleep apnoea syndrome. J Sleep Res. 2000 ; 9: 293-301
46. Gottlieb DJ, Whitney CW, Bonekat WH, et al. Relation of sleepiness to respiratory disturbance index: the Sleep Heart Health Study. Am J Respir Crit Care Med. 1999 ; 159: 502-507
47. McDaid C, Duree KH, Griffin SC, et al. A systematic review of continuous positive airway pressure for obstructive sleep apnoea-hypopnoea syndrome. Sleep Med Rev. 2009 ; 13: 427-436
48. Benbadis SR, Mascha E, Perry MC, Wolgamuth BR, Smolley LA, Dinner DS. Association between the Epworth sleepiness scale and the multiple sleep latency test in a clinical population. Ann Intern Med. 1999 ; 130: 289-292
49. Chervin RD, Aldrich MS, Pickett R, Guilleminault C. Comparison of the results of the Epworth Sleepiness Scale and the Multiple Sleep Latency Test. J Psychosom Res. 1997 ; 42: 145-155
50. Furuta H, Kaneda R, Kosaka K, Arai H, Sano J, Koshino Y. Epworth Sleepiness Scale and sleep studies in patients with obstructive sleep apnea syndrome. Psychiatry Clin Neurosci. 1999 ; 53: 301-302
51. Attarian HP, Brown KM, Duntley SP, Carter JD, Cross AH. The relationship of sleep disturbances and fatigue in multiple sclerosis. Arch Neurol. 2004 ; 61: 525-528
52. Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D. Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology. 2006 ; 44: 91-98
53. Valko PO, Bassetti CL, Bloch KE, Held U, Baumann CR. Validation of the fatigue severity scale in a Swiss cohort. Sleep. 2008 ; 31: 1601-1607
54. Bedard MA, Montplaisir J, Richer F, Malo J. Nocturnal hypoxemia as a determinant of vigilance impairment in sleep apnea syndrome. Chest. 1991 ; 100: 367-370
55. Bennett LS, Langford BA, Stradling JR, Davies RJ. Sleep fragmentation indices as predictors of daytime sleepiness and nCPAP response in obstructive sleep apnea. Am J Respir Crit Care Med. 1998 ; 158: 778-786
56. Zhan G, Fenik P, Pratico D, Veasey SC. Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolence and brain injury. Am J Respir Crit Care Med. 2005 ; 171: 1414-1420
57. Kronholm E, Hyyppa MT, Alanen E, Halonen JP, Partinen M. What does the multiple sleep latency test measure in a community sample?. Sleep. 1995 ; 18: 827-835
58. Kale N, Agaoglu J, Tanik O. Neuropsychiatric manifestations in multiple sclerosis: correlation of fatigue and depression with disease progression. Neurol Res. 2010 ; 32: 221-223
59. Koch M, Mostert J, Heerings M, Uyttenboogaart M, De KJ. Fatigue, depression and disability accumulation in multiple sclerosis: a cross-sectional study. Eur J Neurol. 2009 ; 16: 348-352
60. Patrick E, Christodoulou C, Krupp LB. Longitudinal correlates of fatigue in multiple sclerosis. Mult Scler. 2009 ; 15: 258-261
61. Penner IK, Bechtel N, Raselli C, et al. Fatigue in multiple sclerosis: relation to depression, physical impairment, personality and action control. Mult Scler. 2007 ; 13: 1161-1167
62. Metz LM, Patten SB, Archibald CJ, et al. The effect of immunomodulatory treatment on multiple sclerosis fatigue. J Neurol Neurosurg Psychiatry. 2004 ; 75: 1045-1047