Enhancement in blood-tumor barrier permeability and delivery of liposomal doxorubicin using focused ultrasound and microbubbles: Evaluation during tumor progression in a rat glioma model

Physics in Medicine and Biology

Volumn 60, Issue 6, 2015, Pages 2511-2527

  Aryal, Muna ^a,b   Park, Juyoung ^c   Vykhodtseva, Natalia ^b   Zhang, Yong Zhi ^b   McDannold, Nathan ^b  

^a BOSTON COLLEGE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

blood brain barrier; blood tumor barrier; brain drug delivery; dynamic contrast enhanced RI; focused ultrasound; pharmacokinetic model

Indexed keywords

ANIMALS; BLOOD; BRAIN; CHEMOTHERAPY; DRUG DELIVERY; MAGNETIC RESONANCE IMAGING; RATS; ULTRASONICS;

BLOOD-BRAIN BARRIER; BRAIN DRUG DELIVERIES; DYNAMIC CONTRAST ENHANCED; FOCUSED ULTRASOUND; PHARMACOKINETIC MODEL;

TUMORS;

ANTINEOPLASTIC AGENT; DOXORUBICIN; GADOLINIUM PENTETATE; MACROGOL DERIVATIVE;

ANALOGS AND DERIVATIVES; ANIMAL; BLOOD BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CHEMISTRY; DEVICES; DRUG EFFECTS; GLIOMA; HUMAN; MALE; METABOLISM; MICROBUBBLE; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCEDURES; RAT; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; ULTRASOUND;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CELL LINE, TUMOR; DOXORUBICIN; GADOLINIUM DTPA; GLIOMA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MICROBUBBLES; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SONICATION;

EID: 84924778078     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/60/6/2511     Document Type: Article

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