Mechanism of low-frequency ultrasound in opening blood-tumor barrier by tight junction

Journal of Molecular Neuroscience

Volumn 43, Issue 3, 2011, Pages 364-369

  Shang, Xiuli ^a   Wang, Ping ^a   Liu, Yunhui ^a   Zhang, Zhen ^a   Xue, Yixue ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Blood tumor barrier; Brain tumor; Low frequency ultrasound; Tight junction

Indexed keywords

CLAUDIN 5; EVANS BLUE; MESSENGER RNA; OCCLUDIN; PERFLUTREN; PROTEIN ZO1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD TUMOR BARRIER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GLIA CELL; GLIOMA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOW FREQUENCY ULTRASOUND; MALE; MICROBUBBLE; MICROVASCULAR ENDOTHELIAL CELL; NONHUMAN; PERMEABILITY BARRIER; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION; ULTRASOUND; WESTERN BLOTTING;

ANIMALS; BLOOD-BRAIN BARRIER; MALE; MEMBRANE PROTEINS; MICROBUBBLES; PERMEABILITY; PHOSPHOPROTEINS; RANDOM ALLOCATION; RATS; RATS, WISTAR; TIGHT JUNCTIONS; ULTRASONICS; VASCULAR NEOPLASMS;

EID: 79955860259     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9451-9     Document Type: Article

References (24)

1. Balda MS, Flores-Maldonado C, Cereijido M, Matter K (2000) Multiple domains of occludin are involved in the regulation of paracellular permeability. J Cell Biochem 78(1):85-96 (Pubitemid 30346385)
2. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH (1994) Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 91(6):2076-2080 (Pubitemid 24092045)
3. Cloughesy TF, Black KL (1995) Pharmacological blood-brain barrier modification for selective drug delivery. J Neurooncol 26(2):125-132 (Pubitemid 26004030)
4. Engelhardt B (2006)Molecular mechanisms involved in T cell migration across the blood-brain barrier. J Neural Transm 113(4):477-485
5. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S (1993) Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 123(6 Pt 2):1777-1788 (Pubitemid 24012933)
6. Gonzalez-Mariscal L, Betanzos A, Avila-Flores A (2000) MAGUK proteins: structure and role in the tight junction. Semin Cell Dev Biol 11(4):315-324 (Pubitemid 32066139)
7. Haluska M, Anthony ML (2004) Osmotic blood-brain barrier modification for the treatment of malignant brain tumors. Clin J Oncol Nurs 8(3):263-267
8. Hamstra DA, Moffat BA, Hall DE, Young JM, Desmond TJ, Carter J, Pietronigro D, Frey KA, Rehemtulla A, Ross BD (2005) Intratumoral injection of BCNU in ethanol (DTI-015) results in enhanced delivery to tumor - a pharmacokinetic study. J Neurooncol 73(3):225-238 (Pubitemid 40974018)
9. Harhaj NS, Felinski EA, Wolpert EB, Sundstrom JM, Gardner TW, Antonetti DA (2006) VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci 47(11):5106-5115 (Pubitemid 46586418)
10. Hirase T, Staddon JM, Saitou M, Ando-Akatsuka Y, Itoh M, Furuse M, Fujimoto K, Tsukita S, Rubin LL (1997) Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci 110(Pt 14):1603-1613 (Pubitemid 27338748)
11. Huber D, BaldaMS,Matter K (2000) Occludin modulates transepithelial migration of neutrophils. J Biol Chem 275(8):5773-5778 (Pubitemid 30115221)
12. Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA (2001) Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology 220(3):640-646 (Pubitemid 32799969)
13. Hynynen K, McDannold N, Sheikov NA, Jolesz FA, Vykhodtseva N (2005) Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications. Neuroimage 24(1):12-20 (Pubitemid 39611021)
14. Kemper EM, Verheij M, Boogerd W, Beijnen JH, van Tellingen O (2004) Improved penetration of docetaxel into the brain by coadministration of inhibitors of P-glycoprotein. Eur J Cancer 40 (8):1269-1274 (Pubitemid 38526348)
15. Mardor Y, Rahav O, Zauberman Y, Lidar Z, Ocherashvilli A, Daniels D, Roth Y, Maier SE, Orenstein A, Ram Z (2005) Convection-enhanced drug delivery: increased efficacy and magnetic resonance image monitoring. Cancer Res 65(15):6858-6863 (Pubitemid 41065083)
16. McDannold N, Vykhodtseva N, Hynynen K (2008) Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. Ultrasound Med Biol 34 (6):930-937 (Pubitemid 351697595)
17. Ohtsuki S, Sato S, Yamaguchi H, Kamoi M, Asashima T, Terasaki T (2007) Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cells. J Cell Physiol 210(1):81-86 (Pubitemid 44904703)
18. Pardridge WM (2001) Brain drug targeting and gene technologies. Jpn J Pharmacol 87(2):97-103
19. Raymond SB, Skoch J, Hynynen K, Bacskai BJ (2007) Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. J Cereb Blood Flow Metab 27(2):393-403 (Pubitemid 46148465)
20. Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, Hynynen K (2007) Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer 121(4):901-907 (Pubitemid 47106223)
21. Westphal M, Hilt DC, Bortey E, Delavault P, Olivares R, Warnke PC, Whittle IR, Jaaskelainen J, Ram Z (2003) A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro Oncol 5(2):79-88 (Pubitemid 36422560)
22. Xia CY, Zhang Z, Xue YX, Wang P, Liu YH (2009) Mechanisms of the increase in the permeability of the blood-tumor barrier obtained by combining low-frequency ultrasound irradiation with small-dose bradykinin. J Neurooncol 94(1):41-50
23. Yang FY, Fu WM, Chen WS, Yeh WL, Lin WL (2008) Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption. Ultrason Sonochem 15(4):636-643
24. Zhang Z, Xia C, Xue Y, Liu Y (2009) Synergistic effect of low-frequency ultrasound and low-dose bradykinin on increasing permeability of the blood-tumor barrier by opening tight junction. J Neurosci Res 87(10):2282-2289