Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population

Journal of Nutritional Biochemistry

Volumn 24, Issue 1, 2013, Pages 54-61

  Rudkowska, Iwona ^a,b   Paradis, Ann Marie ^a   Thifault, Elisabeth ^a   Julien, Pierre ^b   Tchernof, André ^b   Couture, Patrick ^a   Lemieux, Simone ^a   Barbier, Olivier ^b   Vohl, Marie Claude ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Lipidomics; Metabolic pathways; Metabolites; Microarray; Nutrigenomics

Indexed keywords

ACYLCARNITINE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLUCOSE; HEXOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 6; LEUCINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYSOPHOSPHATIDYLCHOLINE; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLCHOLINE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD SAMPLING; CAUCASIAN; CLINICAL ARTICLE; CLINICAL TRIAL; DIET RESTRICTION; DIET SUPPLEMENTATION; ERYTHROCYTE; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEART PROTECTION; HUMAN; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MICROARRAY ANALYSIS; NORMAL HUMAN; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; POPULATION; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BLOOD GLUCOSE; CARDIOTONIC AGENTS; CHOLESTEROL; DIETARY SUPPLEMENTS; ERYTHROCYTES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FATTY ACIDS; FATTY ACIDS, OMEGA-3; FEMALE; GENE EXPRESSION PROFILING; HEXOSES; HUMANS; INFLAMMATION; LEUCINE; LIPIDS; MALE; METABOLOMICS; QUEBEC; REFERENCE VALUES;

EID: 84870465239     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.01.016     Document Type: Article

References (45)

1. Calder P.C. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol Nutr Food Res 2008, 52:885-897.
2. Bouwens M., van de Rest O., Dellschaft N., et al. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr 2009, 90:415-424.
3. Kabir M., Skurnik G., Naour N., et al. Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr 2007, 86:1670-1679.
4. Gorjao R., Verlengia R., Lima T.M., et al. Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function. Clin Nutr 2006, 25:923-938.
5. Skulas-Ray A.C., Kris-Etherton P.M., Harris W.S., Vanden Heuvel J.P., Wagner P.R., West S.G. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr 2011, 93:243-252.
6. de Mello V.D., Erkkila A.T., Schwab U.S., et al. The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease. Eur J Nutr 2009, 48:447-455.
7. Lankinen M., Schwab U., Erkkila A., et al. Fatty fish intake decreases lipids related to inflammation and insulin signaling - a lipidomics approach. PLoS One 2009, 4:e5258.
8. McCombie G., Browning L.M., Titman C.M., et al. Omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids. Metabolomics 2009, 5:363-374.
9. McNamara J.R., Schaefer E.J. Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions. Clin Chim Acta 1987, 166:1-8.
10. Burstein M., Samaille J. On a rapid determination of the cholesterol bound to the serum alpha- and beta-lipoproteins. Clin Chim Acta 1960, 5:609.
11. Albers J.J., Warnick G.R., Wiebe D., et al. Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein. Clin Chem 1978, 24:853-856.
12. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
13. Desbuquois B., Aurbach G.D. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 1971, 33:732-738.
14. Richterich R., Dauwalder H. Determination of plasma glucose by hexokinase-glucose-6-phosphate dehydrogenase method. Schweiz Med Wochenschr 1971, 101:615-618.
15. Pirro M., Bergeron J., Dagenais G.R., et al. Age and duration of follow-up as modulators of the risk for ischemic heart disease associated with high plasma C-reactive protein levels in men. Arch Intern Med 2001, 161:2474-2480.
16. Shaikh N.A., Downar E. Time course of changes in porcine myocardial phospholipid levels during ischemia. A reassessment of the lysolipid hypothesis. Circ Res 1981, 49:316-325.
17. Lepage G., Roy C.C. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986, 27:114-120.
18. Blazejczyk M., Miron M., Nadon R. FlexArray: a statistical data analysis software for gene expression microarrays 2007, Genome Quebec, Montreal, Canada.
19. Bolstad B.M., Irizarry R.A., Astrand M., Speed T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003, 19:185-193.
20. Tusher V.G., Tibshirani R., Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001, 98:5116-5121.
21. Altmaier E., Kastenmuller G., Romisch-Margl W., et al. Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics. Eur J Epidemiol 2011, 26:145-156.
22. Rudkowska I., Ponton A., Jacques H., Lavigne C., Holub B.J., Marette A., Vohl M.C. Effects of a supplementation of n-3 polyunsaturated fatty acids with or without fish gelatin on gene expression in peripheral blood mononuclear cells in obese, insulin-resistant subjects. J Nutrigenet Nutrigenomics 2011, 4:192-202.
23. Fruchart J.C., Duriez P., Staels B. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 1999, 10:245-257.
24. Altmaier E., Kastenmuller G., Romisch-Margl W., et al. Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics. Mol Nutr Food Res 2009, 53:1357-1365.
25. Schoonjans K., Staels B., Auwerx J. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996, 1302:93-109.
26. Yoon M., Jeong S., Nicol C.J., et al. Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism. Exp Mol Med 2002, 34:481-488.
27. Trottier J., Caron P., Straka R.J., Barbier O. Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate. Clin Pharmacol Ther 2011.
28. Caron-Dorval D., Paquet P., Paradis A.M., et al. Effect of the PPAR-Alpha L162V polymorphism on the cardiovascular disease risk factor in response to n-3 polyunsaturated fatty acids. J Nutrigenet Nutrigenomics 2008, 1:205-212.
29. Israelian-Konaraki Z., Reaven P.D. Peroxisome proliferator-activated receptor-alpha and atherosclerosis: from basic mechanisms to clinical implications. Cardiol Rev 2005, 13:240-246.
30. Alwayn I.P., Andersson C., Lee S., et al. Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. Am J Physiol Gastrointest Liver Physiol 2006, 291:G1011-G1019.
31. Chapkin R.S., Kim W., Lupton J.R., McMurray D.N. Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation. Prostaglandins Leukot Essent Fatty Acids 2009, 81:187-191.
32. van Meijl L.E., Popeijus H.E., Mensink R.P. Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-kappaB activity in HepG2 liver cells. Mol Nutr Food Res 2010, 54:1568-1573.
33. Li J., Ichikawa T., Villacorta L., et al. Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arterioscler Thromb Vasc Biol 2009, 29:1843-1850.
34. Ishikado A., Nishio Y., Morino K., et al. Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells. Biochem Biophys Res Commun 2010, 402:99-104.
35. Aiyar N., Disa J., Ao Z., et al. Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells. Mol Cell Biochem 2007, 295:113-120.
36. Huang Y.H., Schafer-Elinder L., Wu R., Claesson H.E., Frostegard J. Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism. Clin Exp Immunol 1999, 116:326-331.
37. Camejo G. Lysophospholipids: effectors mediating the contribution of dyslipidemia to calcification associated with atherosclerosis. Atherosclerosis 2010, 211:36-37.
38. Kekkonen R.A., Sysi-Aho M., Seppanen-Laakso T., et al. Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults. World J Gastroenterol 2008, 14:3188-3194.
39. Hartweg J., Perera R., Montori V., Dinneen S., Neil H.A., Farmer A. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus. Cochrane Database Syst Rev 2008, CD003205.
40. Kaushik M., Mozaffarian D., Spiegelman D., Manson J.E., Willett W.C., Hu F.B. Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus. Am J Clin Nutr 2009, 90:613-620.
41. Wymann M.P., Schneiter R. Lipid signalling in disease. Nat Rev Mol Cell Biol 2008, 9:162-176.
42. Turpin S.M., Lancaster G.I., Darby I., Febbraio M.A., Watt M.J. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab 2006, 291:E1341-E1350.
43. Holland W.L., Knotts T.A., Chavez J.A., Wang L.P., Hoehn K.L., Summers S.A. Lipid mediators of insulin resistance. Nutr Rev 2007, 65:S39-S46.
44. Jolly C.A., Jiang Y.H., Chapkin R.S., McMurray D.N. Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide. J Nutr 1997, 127:37-43.
45. Summers S.A. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 2006, 45:42-72.