Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design

Acta Crystallographica Section D: Biological Crystallography

Volumn 71, Issue , 2015, Pages 484-493

  Sprenger, Janina ^a,b   Svensson, Bo ^a,c   Hålander, Jenny ^a   Carey, Jannette ^d   Persson, Lo ^b   Al Karadaghi, Salam ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c SARomics Biostructures AB   (Sweden)

^d PRINCETON UNIVERSITY   (United States)

Author keywords

malaria; Plasmodium falciparum; plyamines; spermidine synthase; structure based drug design

Indexed keywords

PLASMODIUM FALCIPARUM; PYRONIA TITHONUS;

5'-METHYLTHIOADENOSINE; DEOXYADENOSINE DERIVATIVE; ENZYME INHIBITOR; NUCLEOSIDE; PROTOZOAL PROTEIN; PUTRESCINE; SPERMIDINE; SPERMIDINE SYNTHASE;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYMOLOGY; PLASMODIUM FALCIPARUM; PROTEIN TERTIARY STRUCTURE;

DEOXYADENOSINES; ENZYME INHIBITORS; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; PUTRESCINE; SPERMIDINE; SPERMIDINE SYNTHASE; THIONUCLEOSIDES;

EID: 84924765182     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004714027011     Document Type: Article

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