Design and synthesis of C3-pyrazole/chalcone-linked beta-carboline hybrids: antitopoisomerase I, DNA-interactive, and apoptosis-inducing anticancer agents

ChemMedChem

Volumn 9, Issue 9, 2014, Pages 2084-2098

  Kamal, Ahmed ^a   Srinivasulu, Vunnam ^a   Nayak, V Lakshma ^a   Sathish, Manda ^a   Shankaraiah, Nagula ^a   Bagul, Chandrakant ^a   Reddy, N V Subba ^a   Rangaraj, Nandini ^a   Nagesh, Narayana ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

anticancer activity; beta carboline hybrids; DNA binding; DNA photocleavage; topoisomerase I inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOLINE DERIVATIVE; CHALCONE DERIVATIVE; DNA; DNA TOPOISOMERASE INHIBITOR; PYRAZOLE DERIVATIVE;

APOPTOSIS; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DNA CLEAVAGE; DRUG EFFECTS; DRUG SCREENING; HUMAN; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOLINES; CELL CYCLE; CELL LINE, TUMOR; CHALCONES; DNA CLEAVAGE; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; PYRAZOLES; TOPOISOMERASE I INHIBITORS;

EID: 85027942620     PISSN: None     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300406     Document Type: Article

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