Light-activated protein inhibition through photoinduced electron transfer of a ruthenium(II)-cobalt(III) bimetallic complex

Journal of the American Chemical Society

Volumn 137, Issue 9, 2015, Pages 3379-3385

  Holbrook, Robert J ^a   Weinberg, David J ^a   Peterson, Mark D ^a   Weiss, Emily A ^a   Meade, Thomas J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; ELECTRON TRANSITIONS; ENZYMES; FUNCTIONAL GROUPS; LIGANDS; METALS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; REDOX REACTIONS; RUTHENIUM ALLOYS; RUTHENIUM COMPOUNDS;

ACTIVATED PROTEINS; BIMETALLIC COMPLEXES; BIOLOGICALLY INERT; CONFORMATIONAL CHANGE; PHOTO-INDUCED ELECTRON TRANSFER; REDOX ACTIVE METAL CENTERS; THERAPEUTIC AGENTS; THROMBIN INHIBITION;

COBALT COMPOUNDS;

COBALT COMPLEX; COBALT(III); PROTEIN INHIBITOR; RUTHENIUM COMPLEX; RUTHENIUM(II); THROMBIN; UNCLASSIFIED DRUG; 4-METHYLIMIDAZOLE; COBALT; COORDINATION COMPOUND; HISTIDINE; IMIDAZOLE DERIVATIVE; LIGAND; PROTEINASE INHIBITOR; RUTHENIUM; SCHIFF BASE;

ARTICLE; BLOOD CLOTTING; CONFORMATIONAL TRANSITION; ELECTRON TRANSPORT; ENERGY ABSORPTION; ENZYME ACTIVITY; ENZYME INHIBITION ASSAY; HEART INFARCTION; HUMAN; LIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTICAL DENSITY; PHOSPHORESCENCE; PHOTOINDUCED ELECTRON TRANSFER; PROTEIN STRUCTURE; QUANTUM YIELD; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PHOTOCHEMISTRY;

COBALT; COORDINATION COMPLEXES; ELECTRON TRANSPORT; HISTIDINE; IMIDAZOLES; LIGANDS; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PHOTOCHEMICAL PROCESSES; PROTEASE INHIBITORS; RUTHENIUM; SCHIFF BASES; THROMBIN;

EID: 84924709651     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b00342     Document Type: Article

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