Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate

Molecular Pharmaceutics

Volumn 9, Issue 2, 2012, Pages 325-333

  Hurtado, Ryan R ^a   Harney, Allison S ^a   Heffern, Marie C ^a   Holbrook, Robert J ^a   Holmgren, Robert A ^a   Meade, Thomas J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

basal cell carcinoma; cobalt chelate Schiff base; Cubitus Interruptus; development; Drosophila; Hedgehog signaling; transcription factor; zinc fingers

Indexed keywords

COBALT; DNA; DNA BINDING PROTEIN; NUCLEIC ACID BINDING PROTEIN; OLIGONUCLEOTIDE; SCHIFF BASE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR C2H2; TRANSCRIPTION FACTOR CI; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BASAL CELL CARCINOMA; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; DROSOPHILA; DRUG CONJUGATION; EMBRYO; GENE SEQUENCE; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MAMMAL; MEDULLOBLASTOMA; NEOPLASM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; REPORTER GENE; SIGNAL TRANSDUCTION; TISSUE CULTURE; TRANSCRIPTION INITIATION; WILD TYPE;

ANIMALS; CELL LINE; COBALT; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENES, DEVELOPMENTAL; HEDGEHOG PROTEINS; HUMANS; MICE; NEOPLASMS; OLIGONUCLEOTIDES; SCHIFF BASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 84856860513     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2005577     Document Type: Article

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